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Journal Abstract Search

115 related items for PubMed ID: 18774713

  • 1. Optimization of a series of multi-isoform PI3 kinase inhibitors.
    Perry B, Beevers R, Bennett G, Buckley G, Crabbe T, Gowers L, James L, Jenkins K, Lock C, Sabin V, Wright S.
    Bioorg Med Chem Lett; 2008 Oct 01; 18(19):5299-302. PubMed ID: 18774713
    [Abstract] [Full Text] [Related]

  • 2. Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.
    Perry B, Alexander R, Bennett G, Buckley G, Ceska T, Crabbe T, Dale V, Gowers L, Horsley H, James L, Jenkins K, Crépy K, Kulisa C, Lightfoot H, Lock C, Mack S, Morgan T, Nicolas AL, Pitt W, Sabin V, Wright S.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4700-4. PubMed ID: 18644721
    [Abstract] [Full Text] [Related]

  • 3. Pyrazinoindolone inhibitors of MAPKAP-K2.
    Goldberg DR, Choi Y, Cogan D, Corson M, DeLeon R, Gao A, Gruenbaum L, Hao MH, Joseph D, Kashem MA, Miller C, Moss N, Netherton MR, Pargellis CP, Pelletier J, Sellati R, Skow D, Torcellini C, Tseng YC, Wang J, Wasti R, Werneburg B, Wu JP, Xiong Z.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):938-41. PubMed ID: 18221871
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.
    Wang A, Prouty CP, Pelton PD, Yong M, Demarest KT, Murray WV, Kuo GH.
    Bioorg Med Chem Lett; 2010 Feb 15; 20(4):1432-5. PubMed ID: 20089400
    [Abstract] [Full Text] [Related]

  • 5. Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors.
    Ducray R, Ballard P, Barlaam BC, Hickinson MD, Kettle JG, Ogilvie DJ, Trigwell CB.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):959-62. PubMed ID: 18182285
    [Abstract] [Full Text] [Related]

  • 6. Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
    Dinges J, Akritopoulou-Zanze I, Arnold LD, Barlozzari T, Bousquet PF, Cunha GA, Ericsson AM, Iwasaki N, Michaelides MR, Ogawa N, Phelan KM, Rafferty P, Sowin TJ, Stewart KD, Tokuyama R, Xia Z, Zhang HQ.
    Bioorg Med Chem Lett; 2006 Aug 15; 16(16):4371-5. PubMed ID: 16750628
    [Abstract] [Full Text] [Related]

  • 7. Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.
    Powell NA, Ciske FL, Cai C, Holsworth DD, Mennen K, Van Huis CA, Jalaie M, Day J, Mastronardi M, McConnell P, Mochalkin I, Zhang E, Ryan MJ, Bryant J, Collard W, Ferreira S, Gu C, Collins R, Edmunds JJ.
    Bioorg Med Chem; 2007 Sep 01; 15(17):5912-49. PubMed ID: 17574423
    [Abstract] [Full Text] [Related]

  • 8. First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis.
    Laleu B, Gaggini F, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F, Szyndralewiez C, Page P.
    J Med Chem; 2010 Nov 11; 53(21):7715-30. PubMed ID: 20942471
    [Abstract] [Full Text] [Related]

  • 9. Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy.
    Hall A, Billinton A, Brown SH, Clayton NM, Chowdhury A, Giblin GM, Goldsmith P, Hayhow TG, Hurst DN, Kilford IR, Naylor A, Passingham B, Winyard L.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3392-9. PubMed ID: 18462938
    [Abstract] [Full Text] [Related]

  • 10. Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
    Hasui T, Matsunaga N, Ora T, Ohyabu N, Nishigaki N, Imura Y, Igata Y, Matsui H, Motoyaji T, Tanaka T, Habuka N, Sogabe S, Ono M, Siedem CS, Tang TP, Gauthier C, De Meese LA, Boyd SA, Fukumoto S.
    J Med Chem; 2011 Dec 22; 54(24):8616-31. PubMed ID: 22074142
    [Abstract] [Full Text] [Related]

  • 11. Novel tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one: Design, synthesis, model and use as hMAO-B inhibitors.
    Chen R, Xiao J, Ni Y, Xu HF, Zheng M, Tong X, Zhang TT, Liao C, Tang WJ.
    Bioorg Med Chem; 2016 Apr 15; 24(8):1741-8. PubMed ID: 26964672
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.
    Shreder KR, Cajica J, Du L, Fraser A, Hu Y, Kohno Y, Lin EC, Liu SJ, Okerberg E, Pham L, Wu J, Kozarich JW.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4743-6. PubMed ID: 19577470
    [Abstract] [Full Text] [Related]

  • 13. Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition.
    Sakya SM, Shavnya A, Cheng H, Li C, Rast B, Li J, Koss DA, Jaynes BH, Mann DW, Petras CF, Seibel SB, Haven ML, Lynch MP.
    Bioorg Med Chem Lett; 2008 Feb 01; 18(3):1042-5. PubMed ID: 18182290
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, screening, and molecular modeling study of a new series of ROS1 receptor tyrosine kinase inhibitors.
    El-Deeb IM, Park BS, Jung SJ, Yoo KH, Oh CH, Cho SJ, Han DK, Lee JY, Lee SH.
    Bioorg Med Chem Lett; 2009 Oct 01; 19(19):5622-6. PubMed ID: 19700314
    [Abstract] [Full Text] [Related]

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  • 18. A novel series of positive modulators of the AMPA receptor: structure-based lead optimization.
    Jamieson C, Campbell RA, Cumming IA, Gillen KJ, Gillespie J, Kazemier B, Kiczun M, Lamont Y, Lyons AJ, Maclean JK, Martin F, Moir EM, Morrow JA, Pantling J, Rankovic Z, Smith L.
    Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6072-5. PubMed ID: 20817521
    [Abstract] [Full Text] [Related]

  • 19. The discovery of equipotent PPARalpha/gamma dual activators.
    Martres P, Faucher N, Laroze A, Pineau O, Fouchet MH, Potvain F, Grillot D, Beneton V.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6251-4. PubMed ID: 18947994
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