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Journal Abstract Search

456 related items for PubMed ID: 18775471

  • 1. Discovery of novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Su X, Vicker N, Trusselle M, Halem H, Culler MD, Potter BV.
    Mol Cell Endocrinol; 2009 Mar 25; 301(1-2):169-73. PubMed ID: 18775471
    [Abstract] [Full Text] [Related]

  • 2. Discovery of adamantyl ethanone derivatives as potent 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors.
    Su X, Pradaux-Caggiano F, Thomas MP, Szeto MW, Halem HA, Culler MD, Vicker N, Potter BV.
    ChemMedChem; 2010 Jul 05; 5(7):1026-44. PubMed ID: 20486152
    [Abstract] [Full Text] [Related]

  • 3. Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Su X, Vicker N, Ganeshapillai D, Smith A, Purohit A, Reed MJ, Potter BV.
    Mol Cell Endocrinol; 2006 Mar 27; 248(1-2):214-7. PubMed ID: 16325333
    [Abstract] [Full Text] [Related]

  • 4. The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.
    Schuster D, Maurer EM, Laggner C, Nashev LG, Wilckens T, Langer T, Odermatt A.
    J Med Chem; 2006 Jun 15; 49(12):3454-66. PubMed ID: 16759088
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
    Yang H, Dou W, Lou J, Leng Y, Shen J.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1340-5. PubMed ID: 18242087
    [Abstract] [Full Text] [Related]

  • 6. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2674-8. PubMed ID: 19395260
    [Abstract] [Full Text] [Related]

  • 7. Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
    Hult M, Shafqat N, Elleby B, Mitschke D, Svensson S, Forsgren M, Barf T, Vallgårda J, Abrahmsen L, Oppermann U.
    Mol Cell Endocrinol; 2006 Mar 27; 248(1-2):26-33. PubMed ID: 16431016
    [Abstract] [Full Text] [Related]

  • 8. Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Tu H, Powers JP, Liu J, Ursu S, Sudom A, Yan X, Xu H, Meininger D, Degraffenreid M, He X, Jaen JC, Sun D, Labelle M, Yamamoto H, Shan B, Walker NP, Wang Z.
    Bioorg Med Chem; 2008 Oct 01; 16(19):8922-31. PubMed ID: 18789704
    [Abstract] [Full Text] [Related]

  • 9. Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
    Shah U, Boyle CD, Chackalamannil S, Baker H, Kowalski T, Lee J, Terracina G, Zhang L.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1551-4. PubMed ID: 20149650
    [Abstract] [Full Text] [Related]

  • 10. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
    Sun D, Wang Z, Di Y, Jaen JC, Labelle M, Ma J, Miao S, Sudom A, Tang L, Tomooka CS, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3513-6. PubMed ID: 18511278
    [Abstract] [Full Text] [Related]

  • 11. Recent advances in the discovery of 11beta-HSD1 inhibitors.
    Boyle CD.
    Curr Opin Drug Discov Devel; 2008 Jul 15; 11(4):495-511. PubMed ID: 18600567
    [Abstract] [Full Text] [Related]

  • 12. 11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.
    Tomlinson JW.
    Minerva Endocrinol; 2005 Mar 15; 30(1):37-46. PubMed ID: 15877012
    [Abstract] [Full Text] [Related]

  • 13.
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  • 14. 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
    Johansson L, Fotsch C, Bartberger MD, Castro VM, Chen M, Emery M, Gustafsson S, Hale C, Hickman D, Homan E, Jordan SR, Komorowski R, Li A, McRae K, Moniz G, Matsumoto G, Orihuela C, Palm G, Veniant M, Wang M, Williams M, Zhang J.
    J Med Chem; 2008 May 22; 51(10):2933-43. PubMed ID: 18419108
    [Abstract] [Full Text] [Related]

  • 15.
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  • 16. Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species.
    Arampatzis S, Kadereit B, Schuster D, Balazs Z, Schweizer RA, Frey FJ, Langer T, Odermatt A.
    J Mol Endocrinol; 2005 Aug 22; 35(1):89-101. PubMed ID: 16087724
    [Abstract] [Full Text] [Related]

  • 17. Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Sutin L, Andersson S, Bergquist L, Castro VM, Danielsson E, James S, Henriksson M, Johansson L, Kaiser C, Flyrén K, Williams M.
    Bioorg Med Chem Lett; 2007 Sep 01; 17(17):4837-40. PubMed ID: 17600707
    [Abstract] [Full Text] [Related]

  • 18. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
    Wan ZK, Chenail E, Xiang J, Li HQ, Ipek M, Bard J, Svenson K, Mansour TS, Xu X, Tian X, Suri V, Hahm S, Xing Y, Johnson CE, Li X, Qadri A, Panza D, Perreault M, Tobin JF, Saiah E.
    J Med Chem; 2009 Sep 10; 52(17):5449-61. PubMed ID: 19673466
    [Abstract] [Full Text] [Related]

  • 19. The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
    Neelamkavil SF, Boyle CD, Chackalamannil S, Greenlee WJ, Zhang L, Terracina G.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4563-5. PubMed ID: 19625185
    [Abstract] [Full Text] [Related]

  • 20. Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.
    Iwasaki Y, Takayasu S, Nishiyama M, Tsugita M, Taguchi T, Asai M, Yoshida M, Kambayashi M, Hashimoto K.
    Mol Cell Endocrinol; 2008 Mar 26; 285(1-2):10-8. PubMed ID: 18313835
    [Abstract] [Full Text] [Related]

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