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253 related items for PubMed ID: 18790746

  • 1. Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
    Park MA, Zhang G, Mitchell C, Rahmani M, Hamed H, Hagan MP, Yacoub A, Curiel DT, Fisher PB, Grant S, Dent P.
    Mol Cancer Ther; 2008 Sep; 7(9):2633-48. PubMed ID: 18790746
    [Abstract] [Full Text] [Related]

  • 2. 17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species.
    Walker T, Mitchell C, Park MA, Yacoub A, Rahmani M, Häussinger D, Reinehr R, Voelkel-Johnson C, Fisher PB, Grant S, Dent P.
    Mol Cancer Ther; 2010 May; 9(5):1378-95. PubMed ID: 20442308
    [Abstract] [Full Text] [Related]

  • 3. 17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines.
    Mitchell C, Park MA, Zhang G, Han SI, Harada H, Franklin RA, Yacoub A, Li PL, Hylemon PB, Grant S, Dent P.
    Mol Cancer Ther; 2007 Feb; 6(2):618-32. PubMed ID: 17308059
    [Abstract] [Full Text] [Related]

  • 4. HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase.
    Hioki T, Tokuda H, Nakashima D, Fujita K, Kawabata T, Sakai G, Kim W, Tachi J, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O.
    Cell Biochem Funct; 2021 Jan; 39(1):88-97. PubMed ID: 32567086
    [Abstract] [Full Text] [Related]

  • 5. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.
    Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, Dent P.
    Mol Biol Cell; 2001 Sep; 12(9):2629-45. PubMed ID: 11553704
    [Abstract] [Full Text] [Related]

  • 6. Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
    Zhang G, Park MA, Mitchell C, Hamed H, Rahmani M, Martin AP, Curiel DT, Yacoub A, Graf M, Lee R, Roberts JD, Fisher PB, Grant S, Dent P.
    Clin Cancer Res; 2008 Sep 01; 14(17):5385-99. PubMed ID: 18765530
    [Abstract] [Full Text] [Related]

  • 7. Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors.
    Vaseva AV, Yallowitz AR, Marchenko ND, Xu S, Moll UM.
    Cell Death Dis; 2011 May 12; 2(5):e156. PubMed ID: 21562588
    [Abstract] [Full Text] [Related]

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  • 9. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
    Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S.
    Cancer Res; 2002 Jan 01; 62(1):188-99. PubMed ID: 11782377
    [Abstract] [Full Text] [Related]

  • 10. Sorafenib and HDAC inhibitors synergize with TRAIL to kill tumor cells.
    Hamed HA, Yamaguchi Y, Fisher PB, Grant S, Dent P.
    J Cell Physiol; 2013 Oct 01; 228(10):1996-2005. PubMed ID: 23674352
    [Abstract] [Full Text] [Related]

  • 11. A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
    Park MA, Hamed HA, Mitchell C, Cruickshanks N, Dash R, Allegood J, Dmitriev IP, Tye G, Ogretmen B, Spiegel S, Yacoub A, Grant S, Curiel DT, Fisher PB, Dent P.
    Mol Pharmacol; 2011 Mar 01; 79(3):368-80. PubMed ID: 21119025
    [Abstract] [Full Text] [Related]

  • 12. MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
    Park MA, Walker T, Martin AP, Allegood J, Vozhilla N, Emdad L, Sarkar D, Rahmani M, Graf M, Yacoub A, Koumenis C, Spiegel S, Curiel DT, Voelkel-Johnson C, Grant S, Fisher PB, Dent P.
    Mol Cancer Ther; 2009 May 01; 8(5):1280-91. PubMed ID: 19417161
    [Abstract] [Full Text] [Related]

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  • 15. Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells.
    Yacoub A, Liu R, Park MA, Hamed HA, Dash R, Schramm DN, Sarkar D, Dimitriev IP, Bell JK, Grant S, Farrell NP, Curiel DT, Fisher PB, Dent P.
    Mol Pharmacol; 2010 Feb 01; 77(2):298-310. PubMed ID: 19910452
    [Abstract] [Full Text] [Related]

  • 16. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.
    Eur J Pharmacol; 2007 Jun 01; 563(1-3):49-60. PubMed ID: 17341418
    [Abstract] [Full Text] [Related]

  • 17. Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells.
    Lu B, Wang L, Stehlik C, Medan D, Huang C, Hu S, Chen F, Shi X, Rojanasakul Y.
    J Immunol; 2006 Jun 01; 176(11):6785-93. PubMed ID: 16709838
    [Abstract] [Full Text] [Related]

  • 18. Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death.
    Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA.
    Mol Cancer Ther; 2009 Aug 01; 8(8):2183-92. PubMed ID: 19671754
    [Abstract] [Full Text] [Related]

  • 19. Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
    Vrana JA, Grant S.
    Blood; 2001 Apr 01; 97(7):2105-14. PubMed ID: 11264178
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