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Journal Abstract Search

112 related items for PubMed ID: 18800766

  • 1. Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
    Zlatev I, Dutartre H, Barvik I, Neyts J, Canard B, Vasseur JJ, Alvarez K, Morvan F.
    J Med Chem; 2008 Sep 25; 51(18):5745-57. PubMed ID: 18800766
    [Abstract] [Full Text] [Related]

  • 2. 3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity.
    Priet S, Zlatev I, Barvik I, Geerts K, Leyssen P, Neyts J, Dutartre H, Canard B, Vasseur JJ, Morvan F, Alvarez K.
    J Med Chem; 2010 Sep 23; 53(18):6608-17. PubMed ID: 20799693
    [Abstract] [Full Text] [Related]

  • 3. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.
    Chan L, Pereira O, Reddy TJ, Das SK, Poisson C, Courchesne M, Proulx M, Siddiqui A, Yannopoulos CG, Nguyen-Ba N, Roy C, Nasturica D, Moinet C, Bethell R, Hamel M, L'Heureux L, David M, Nicolas O, Courtemanche-Asselin P, Brunette S, Bilimoria D, Bédard J.
    Bioorg Med Chem Lett; 2004 Feb 09; 14(3):797-800. PubMed ID: 14741292
    [Abstract] [Full Text] [Related]

  • 4. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
    Chan L, Das SK, Reddy TJ, Poisson C, Proulx M, Pereira O, Courchesne M, Roy C, Wang W, Siddiqui A, Yannopoulos CG, Nguyen-Ba N, Labrecque D, Bethell R, Hamel M, Courtemanche-Asselin P, L'Heureux L, David M, Nicolas O, Brunette S, Bilimoria D, Bédard J.
    Bioorg Med Chem Lett; 2004 Feb 09; 14(3):793-6. PubMed ID: 14741291
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
    Zhou L, Amblard F, Zhang H, McBrayer TR, Detorio MA, Whitaker T, Coats SJ, Schinazi RF.
    Bioorg Med Chem Lett; 2013 Jun 01; 23(11):3385-8. PubMed ID: 23623492
    [Abstract] [Full Text] [Related]

  • 6. Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.
    Mish MR, Cho A, Kirschberg T, Xu J, Zonte CS, Fenaux M, Park Y, Babusis D, Feng JY, Ray AS, Kim CU.
    Bioorg Med Chem Lett; 2014 Jul 15; 24(14):3092-5. PubMed ID: 24907145
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  • 7. Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
    Chang W, Du J, Rachakonda S, Ross BS, Convers-Reignier S, Yau WT, Pons JF, Murakami E, Bao H, Steuer HM, Furman PA, Otto MJ, Sofia MJ.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4539-43. PubMed ID: 20580554
    [Abstract] [Full Text] [Related]

  • 8. Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
    Kirschberg TA, Metobo S, Clarke MO, Aktoudianakis V, Babusis D, Barauskas O, Birkus G, Butler T, Byun D, Chin G, Doerffler E, Edwards TE, Fenaux M, Lee R, Lew W, Mish MR, Murakami E, Park Y, Squires NH, Tirunagari N, Wang T, Whitcomb M, Xu J, Yang H, Ye H, Zhang L, Appleby TC, Feng JY, Ray AS, Cho A, Kim CU.
    Bioorg Med Chem Lett; 2017 Apr 15; 27(8):1840-1847. PubMed ID: 28274633
    [Abstract] [Full Text] [Related]

  • 9. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
    Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.
    Antimicrob Agents Chemother; 2010 Aug 15; 54(8):3187-96. PubMed ID: 20516278
    [Abstract] [Full Text] [Related]

  • 10. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.
    Cho A, Zhang L, Xu J, Lee R, Butler T, Metobo S, Aktoudianakis V, Lew W, Ye H, Clarke M, Doerffler E, Byun D, Wang T, Babusis D, Carey AC, German P, Sauer D, Zhong W, Rossi S, Fenaux M, McHutchison JG, Perry J, Feng J, Ray AS, Kim CU.
    J Med Chem; 2014 Mar 13; 57(5):1812-25. PubMed ID: 23547794
    [Abstract] [Full Text] [Related]

  • 11. A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.
    Liu J, Du J, Wang P, Nagarathnam D, Espiritu CL, Bao H, Murakami E, Furman PA, Sofia MJ.
    Nucleosides Nucleotides Nucleic Acids; 2012 Apr 13; 31(4):277-85. PubMed ID: 22444190
    [Abstract] [Full Text] [Related]

  • 12. Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.
    Ishida T, Suzuki T, Hirashima S, Mizutani K, Yoshida A, Ando I, Ikeda S, Adachi T, Hashimoto H.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1859-63. PubMed ID: 16455252
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  • 15. Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.
    Beaulieu PL, Bousquet Y, Gauthier J, Gillard J, Marquis M, McKercher G, Pellerin C, Valois S, Kukolj G.
    J Med Chem; 2004 Dec 30; 47(27):6884-92. PubMed ID: 15615537
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  • 16. A novel HCV NS3 protease mutation selected by combination treatment of the protease inhibitor boceprevir and NS5B polymerase inhibitors.
    Chase R, Skelton A, Xia E, Curry S, Liu S, McMonagle P, Huang HC, Tong X.
    Antiviral Res; 2009 Nov 30; 84(2):178-84. PubMed ID: 19747948
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  • 18. Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
    McKercher G, Beaulieu PL, Lamarre D, LaPlante S, Lefebvre S, Pellerin C, Thauvette L, Kukolj G.
    Nucleic Acids Res; 2004 Nov 30; 32(2):422-31. PubMed ID: 14739234
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  • 20. Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism.
    Lougiakis N, Frakolaki E, Karmou P, Pouli N, Marakos P, Madan V, Bartenschlager R, Vassilaki N.
    Chem Biol Drug Des; 2017 Sep 30; 90(3):352-367. PubMed ID: 28245093
    [Abstract] [Full Text] [Related]

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