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147 related items for PubMed ID: 18805488

  • 1. Caspase inhibition attenuates accumulation of beta-amyloid by reducing beta-secretase production and activity in rat brains after stroke.
    Xiong M, Zhang T, Zhang LM, Lu SD, Huang YL, Sun FY.
    Neurobiol Dis; 2008 Dec; 32(3):433-41. PubMed ID: 18805488
    [Abstract] [Full Text] [Related]

  • 2. Exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation and beta-amyloid generation in rat brains.
    Zhang T, Pan BS, Zhao B, Zhang LM, Huang YL, Sun FY.
    Neuroscience; 2009 Jul 21; 161(4):1045-56. PubMed ID: 19376202
    [Abstract] [Full Text] [Related]

  • 3. Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.
    Zhang Y, Xiong M, Yan RQ, Sun FY.
    J Cereb Blood Flow Metab; 2010 Mar 21; 30(3):566-75. PubMed ID: 19844237
    [Abstract] [Full Text] [Related]

  • 4. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar 21; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 5. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.
    J Neurosci Res; 2007 Jan 21; 85(1):153-65. PubMed ID: 17075903
    [Abstract] [Full Text] [Related]

  • 6. Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
    Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW.
    Brain Res; 2004 May 29; 1009(1-2):1-8. PubMed ID: 15120577
    [Abstract] [Full Text] [Related]

  • 7. Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo.
    Elvang AB, Volbracht C, Pedersen LØ, Jensen KG, Karlsson JJ, Larsen SA, Mørk A, Stensbøl TB, Bastlund JF.
    J Neurochem; 2009 Sep 29; 110(5):1377-87. PubMed ID: 19519664
    [Abstract] [Full Text] [Related]

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  • 9. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.
    Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J.
    Neurobiol Dis; 2009 Jul 29; 35(1):103-13. PubMed ID: 19426802
    [Abstract] [Full Text] [Related]

  • 10. Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats.
    Li S, Wang W, Wang C, Tang YY.
    Neurosci Lett; 2010 Feb 12; 470(2):106-10. PubMed ID: 20043977
    [Abstract] [Full Text] [Related]

  • 11. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N'Kuli F, Courtoy PJ, Octave JN.
    J Neurosci Res; 2006 Nov 01; 84(6):1311-22. PubMed ID: 16941495
    [Abstract] [Full Text] [Related]

  • 12. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
    Lin HC, Hsieh HM, Chen YH, Hu ML.
    Neurotoxicology; 2009 Jul 01; 30(4):622-7. PubMed ID: 19635394
    [Abstract] [Full Text] [Related]

  • 13. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.
    J Pharmacol Exp Ther; 2008 Aug 01; 326(2):502-13. PubMed ID: 18499745
    [Abstract] [Full Text] [Related]

  • 14. Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].
    Best JD, Jay MT, Otu F, Ma J, Nadin A, Ellis S, Lewis HD, Pattison C, Reilly M, Harrison T, Shearman MS, Williamson TL, Atack JR.
    J Pharmacol Exp Ther; 2005 May 01; 313(2):902-8. PubMed ID: 15743924
    [Abstract] [Full Text] [Related]

  • 15. Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains.
    Harada H, Tamaoka A, Ishii K, Shoji S, Kametaka S, Kametani F, Saito Y, Murayama S.
    Neurosci Res; 2006 Jan 01; 54(1):24-9. PubMed ID: 16290302
    [Abstract] [Full Text] [Related]

  • 16. Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain.
    Ye JT, Pi RB, Mao XX, Chen XH, Qin J, Xu SW, Liu PQ.
    Neuroreport; 2009 Oct 28; 20(16):1456-60. PubMed ID: 19809370
    [Abstract] [Full Text] [Related]

  • 17. Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts.
    Ebina M, Futai E, Tanabe C, Sasagawa N, Kiso Y, Ishiura S.
    J Neurosci Res; 2009 Feb 28; 87(2):360-8. PubMed ID: 18798280
    [Abstract] [Full Text] [Related]

  • 18. The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease.
    Borghi R, Patriarca S, Traverso N, Piccini A, Storace D, Garuti A, Gabriella Cirmena, Patrizio Odetti, Massimo Tabaton.
    Neurobiol Aging; 2007 Jul 28; 28(7):1009-14. PubMed ID: 16769154
    [Abstract] [Full Text] [Related]

  • 19. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.
    Hampel H, Shen Y.
    Scand J Clin Lab Invest; 2009 Jul 28; 69(1):8-12. PubMed ID: 18609117
    [Abstract] [Full Text] [Related]

  • 20. [Effect of estrogen-depletion and 17beta-estradiol replacement therapy upon rat hippocampus beta-amyloid generation].
    Yang HQ, Sun ZK, Jiang QH, Shang Q, Xu J.
    Zhonghua Yi Xue Za Zhi; 2009 Oct 13; 89(37):2658-61. PubMed ID: 20137687
    [Abstract] [Full Text] [Related]

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