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161 related items for PubMed ID: 18809221

  • 1. The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis.
    Vrenken TE, Buist-Homan M, Kalsbeek AJ, Faber KN, Moshage H.
    J Hepatol; 2008 Nov; 49(5):799-809. PubMed ID: 18809221
    [Abstract] [Full Text] [Related]

  • 2. Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes.
    Karimian G, Buist-Homan M, Faber KN, Moshage H.
    PLoS One; 2012 Nov; 7(8):e43156. PubMed ID: 22900098
    [Abstract] [Full Text] [Related]

  • 3. Metformin protects rat hepatocytes against bile acid-induced apoptosis.
    Woudenberg-Vrenken TE, Conde de la Rosa L, Buist-Homan M, Faber KN, Moshage H.
    PLoS One; 2013 Nov; 8(8):e71773. PubMed ID: 23951244
    [Abstract] [Full Text] [Related]

  • 4. Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.
    Karimian G, Buist-Homan M, Mikus B, Henning RH, Faber KN, Moshage H.
    PLoS One; 2012 Nov; 7(12):e52647. PubMed ID: 23300732
    [Abstract] [Full Text] [Related]

  • 5. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.
    Manna SK, Aggarwal BB.
    J Immunol; 1999 Feb 15; 162(4):2095-102. PubMed ID: 9973483
    [Abstract] [Full Text] [Related]

  • 6. Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes.
    Latchoumycandane C, Seah QM, Tan RC, Sattabongkot J, Beerheide W, Boelsterli UA.
    Toxicol Appl Pharmacol; 2006 Nov 15; 217(1):125-33. PubMed ID: 16979204
    [Abstract] [Full Text] [Related]

  • 7. An active metabolite of leflunomide, A77 1726, inhibits the production of serum amyloid A protein in human hepatocytes.
    Migita K, Miyashita T, Maeda Y, Nakamura M, Yatsuhashi H, Ishibashi H, Eguchi K.
    Rheumatology (Oxford); 2005 Apr 15; 44(4):443-8. PubMed ID: 15695308
    [Abstract] [Full Text] [Related]

  • 8. Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
    Vergne-Salle P, Léger DY, Bertin P, Trèves R, Beneytout JL, Liagre B.
    Cytokine; 2005 Sep 07; 31(5):335-48. PubMed ID: 16099671
    [Abstract] [Full Text] [Related]

  • 9. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.
    Schoemaker MH, Conde de la Rosa L, Buist-Homan M, Vrenken TE, Havinga R, Poelstra K, Haisma HJ, Jansen PL, Moshage H.
    Hepatology; 2004 Jun 07; 39(6):1563-73. PubMed ID: 15185297
    [Abstract] [Full Text] [Related]

  • 10. The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1.
    Moon SJ, Kim EK, Jhun JY, Lee HJ, Lee WS, Park SH, Cho ML, Min JK.
    J Transl Med; 2017 Feb 13; 15(1):31. PubMed ID: 28193225
    [Abstract] [Full Text] [Related]

  • 11. Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers.
    Rust C, Bauchmuller K, Bernt C, Vennegeerts T, Fickert P, Fuchsbichler A, Beuers U.
    Gut; 2006 May 13; 55(5):719-27. PubMed ID: 16322111
    [Abstract] [Full Text] [Related]

  • 12. The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes.
    Palmer G, Burger D, Mezin F, Magne D, Gabay C, Dayer JM, Guerne PA.
    Arthritis Res Ther; 2004 May 13; 6(3):R181-9. PubMed ID: 15142263
    [Abstract] [Full Text] [Related]

  • 13. In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1.
    Williams CR, Sykes JE, Mehl M, MacLeod JS, Lindsay LL, Poland AM, Chen YJ, Kyles AE, Waldman WJ, Gregory CR.
    Am J Vet Res; 2007 Sep 13; 68(9):1010-5. PubMed ID: 17764417
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress.
    Doscas ME, Williamson AJ, Usha L, Bogachkov Y, Rao GS, Xiao F, Wang Y, Ruby C, Kaufman H, Zhou J, Williams JW, Li Y, Xu X.
    Neoplasia; 2014 Oct 13; 16(10):824-34. PubMed ID: 25379019
    [Abstract] [Full Text] [Related]

  • 15. Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes.
    Woudenberg-Vrenken TE, Buist-Homan M, Conde de la Rosa L, Faber KN, Moshage H.
    Liver Int; 2010 Nov 13; 30(10):1511-21. PubMed ID: 20825559
    [Abstract] [Full Text] [Related]

  • 16. The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha.
    Magne D, Mézin F, Palmer G, Guerne PA.
    Inflamm Res; 2006 Nov 13; 55(11):469-75. PubMed ID: 17122964
    [Abstract] [Full Text] [Related]

  • 17. Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.
    Shi Q, Yang X, Greenhaw J, Salminen WF.
    Toxicol Sci; 2011 Aug 13; 122(2):579-86. PubMed ID: 21546349
    [Abstract] [Full Text] [Related]

  • 18. Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726.
    Seah QM, New LS, Chan EC, Boelsterli UA.
    Drug Metab Lett; 2008 Aug 13; 2(3):153-7. PubMed ID: 19356086
    [Abstract] [Full Text] [Related]

  • 19. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress.
    Wu Z, Geng Y, Buist-Homan M, Moshage H.
    Toxicol Appl Pharmacol; 2022 Feb 01; 436():115858. PubMed ID: 34979142
    [Abstract] [Full Text] [Related]

  • 20. Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis.
    Karimian G, Buist-Homan M, Schmidt M, Tietge UJ, de Boer JF, Klappe K, Kok JW, Combettes L, Tordjmann T, Faber KN, Moshage H.
    Biochim Biophys Acta; 2013 Dec 01; 1832(12):1922-9. PubMed ID: 23816565
    [Abstract] [Full Text] [Related]

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