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Journal Abstract Search

640 related items for PubMed ID: 18842703

  • 1. Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: the contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells.
    Ikemura K, Urano K, Matsuda H, Mizutani H, Iwamoto T, Okuda M.
    J Pharmacol Exp Ther; 2009 Jan; 328(1):249-55. PubMed ID: 18842703
    [Abstract] [Full Text] [Related]

  • 2. An antioxidant Trolox restores decreased oral absorption of cyclosporine A after liver ischemia-reperfusion through distinct mechanisms between CYP3A and P-glycoprotein in the small intestine.
    Ikemura K, Inoue K, Mizutani H, Oka H, Iwamoto T, Okuda M.
    Eur J Pharmacol; 2012 Sep 05; 690(1-3):192-201. PubMed ID: 22749977
    [Abstract] [Full Text] [Related]

  • 3. Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats.
    Hirunpanich V, Katagi J, Sethabouppha B, Sato H.
    Drug Metab Dispos; 2006 Feb 05; 34(2):305-10. PubMed ID: 16299163
    [Abstract] [Full Text] [Related]

  • 4. Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine.
    Saitoh H, Saikachi Y, Kobayashi M, Yamaguchi M, Oda M, Yuhki Y, Achiwa K, Tadano K, Takahashi Y, Aungst BJ.
    Eur J Pharm Sci; 2006 May 05; 28(1-2):34-42. PubMed ID: 16457995
    [Abstract] [Full Text] [Related]

  • 5. Effects of liver fibrosis on verapamil pharmacokinetics in rats.
    Chen M, Xu D, Hu XL, Wang H.
    Clin Exp Pharmacol Physiol; 2008 Mar 05; 35(3):287-94. PubMed ID: 17973928
    [Abstract] [Full Text] [Related]

  • 6. Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: in vitro and in vivo studies in rats.
    Hirunpanich V, Murakoso K, Sato H.
    Int J Pharm; 2008 Mar 03; 351(1-2):133-43. PubMed ID: 18082981
    [Abstract] [Full Text] [Related]

  • 7. Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats.
    Konishi H, Sumi M, Shibata N, Takada K, Minouchi T, Yamaji A.
    J Pharm Pharmacol; 2004 Oct 03; 56(10):1259-66. PubMed ID: 15482640
    [Abstract] [Full Text] [Related]

  • 8. Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats.
    Zhang W, Tan TM, Lim LY.
    Drug Metab Dispos; 2007 Jan 03; 35(1):110-5. PubMed ID: 17050652
    [Abstract] [Full Text] [Related]

  • 9. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).
    Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M.
    Int J Pharm; 2010 Apr 15; 389(1-2):114-21. PubMed ID: 20097278
    [Abstract] [Full Text] [Related]

  • 10. Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys.
    Ogasawara A, Kume T, Kazama E.
    Drug Metab Dispos; 2007 Mar 15; 35(3):410-8. PubMed ID: 17142564
    [Abstract] [Full Text] [Related]

  • 11. Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey.
    Ward KW, Stelman GJ, Morgan JA, Zeigler KS, Azzarano LM, Kehler JR, McSurdy-Freed JE, Proksch JW, Smith BR.
    Drug Metab Dispos; 2004 Feb 15; 32(2):172-7. PubMed ID: 14744938
    [Abstract] [Full Text] [Related]

  • 12. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.
    Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ.
    J Pharmacol Exp Ther; 1998 Oct 15; 287(1):246-52. PubMed ID: 9765344
    [Abstract] [Full Text] [Related]

  • 13. Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp.
    Qiu W, Jiang XH, Liu CX, Ju Y, Jin JX.
    Phytother Res; 2009 Nov 15; 23(11):1553-8. PubMed ID: 19370549
    [Abstract] [Full Text] [Related]

  • 14. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .
    Lin JH, Chiba M, Chen IW, Nishime JA, deLuna FA, Yamazaki M, Lin YJ.
    Drug Metab Dispos; 1999 Oct 15; 27(10):1187-93. PubMed ID: 10497146
    [Abstract] [Full Text] [Related]

  • 15. Elevated blood concentrations of calcineurin inhibitors during diarrheal episode in pediatric liver transplant recipients: involvement of the suppression of intestinal cytochrome P450 3A and P-glycoprotein.
    Maezono S, Sugimoto K, Sakamoto K, Ohmori M, Hishikawa S, Mizuta K, Kawarasaki H, Watanabe Y, Fujimura A.
    Pediatr Transplant; 2005 Jun 15; 9(3):315-23. PubMed ID: 15910387
    [Abstract] [Full Text] [Related]

  • 16. Stereoselective first-pass metabolism of verapamil in the small intestine and liver in rats.
    Hanada K, Ikemi Y, Kukita K, Mihara K, Ogata H.
    Drug Metab Dispos; 2008 Oct 15; 36(10):2037-42. PubMed ID: 18617604
    [Abstract] [Full Text] [Related]

  • 17. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies.
    Sharma P, Varma MV, Chawla HP, Panchagnula R.
    Farmaco; 2005 Oct 15; 60(11-12):874-83. PubMed ID: 16243320
    [Abstract] [Full Text] [Related]

  • 18. Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.
    Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA.
    J Pharmacol Exp Ther; 2003 Mar 15; 304(3):1161-71. PubMed ID: 12604693
    [Abstract] [Full Text] [Related]

  • 19. Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model.
    Fujita T, Yasuda S, Kamata Y, Fujita K, Ohtani Y, Kumagai Y, Majima M.
    J Pharmacol Exp Ther; 2008 Nov 15; 327(2):592-9. PubMed ID: 18725544
    [Abstract] [Full Text] [Related]

  • 20. Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability.
    Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF.
    Drug Metab Dispos; 1995 Dec 15; 23(12):1315-24. PubMed ID: 8689938
    [Abstract] [Full Text] [Related]

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