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Journal Abstract Search

113 related items for PubMed ID: 18855917

  • 1. A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE).
    Ouyang H, Andersen TE, Chen W, Nofsinger R, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jun; 98(6):2227-36. PubMed ID: 18855917
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  • 2. Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.
    Chen W, Yang JZ, Andersen R, Nielsen LH, Borchardt RT.
    J Pharmacol Exp Ther; 2002 Nov; 303(2):849-57. PubMed ID: 12388672
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  • 3. Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.
    Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT.
    J Pharm Sci; 2009 Jan; 98(1):337-48. PubMed ID: 18537149
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  • 6. Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human.
    Liederer BM, Borchardt RT.
    J Pharm Sci; 2005 Oct; 94(10):2198-206. PubMed ID: 16136552
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  • 7. Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration.
    Liederer BM, Phan KT, Ouyang H, Borchardt RT.
    J Pharm Sci; 2005 Dec; 94(12):2676-87. PubMed ID: 16258984
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  • 8. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs.
    Yang JZ, Chen W, Borchardt RT.
    J Pharmacol Exp Ther; 2002 Nov; 303(2):840-8. PubMed ID: 12388671
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  • 10. Acyloxyalkoxy-based cyclic prodrugs of opioid peptides: evaluation of the chemical and enzymatic stability as well as their transport properties across Caco-2 cell monolayers.
    Bak A, Gudmundsson OS, Friis GJ, Siahaan TJ, Borchardt RT.
    Pharm Res; 1999 Jan; 16(1):24-9. PubMed ID: 9950274
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  • 14. Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of an acyloxyalkoxy-based cyclic prodrug of the opioid peptide DADLE.
    Tang F, Borchardt RT.
    Pharm Res; 2002 Jun; 19(6):780-6. PubMed ID: 12134947
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  • 17. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa.
    Nofsinger R, Borchardt RT.
    J Pharm Sci; 2012 Sep; 101(9):3500-10. PubMed ID: 22337204
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  • 18. In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
    Hsiao P, Bui T, Ho RJ, Unadkat JD.
    Drug Metab Dispos; 2008 Mar; 36(3):481-4. PubMed ID: 18057117
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  • 19. The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability.
    Gudmundsson OS, Vander Velde DG, Jois SD, Bak A, Siahaan TJ, Borchardt RT.
    J Pept Res; 1999 Apr; 53(4):403-13. PubMed ID: 10406218
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  • 20. Amino acid prodrug of quinidine: an approach to circumvent P-glycoprotein mediated cellular efflux.
    Patel M, Mandava NK, Pal D, Mitra AK.
    Int J Pharm; 2014 Apr 10; 464(1-2):196-204. PubMed ID: 24440401
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