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321 related items for PubMed ID: 1894196

  • 1. Structure-function and refolding studies of the thrombin-specific inhibitor hirudin.
    Johnson PH, Sze P, Winant RC, Hudson D, Underhill P, Lazar JB, Olsen C, Almquist R.
    Haemostasis; 1991; 21 Suppl 1():41-8. PubMed ID: 1894196
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity relationships of recombinant hirudins.
    Stürzebecher J, Walsmann P.
    Semin Thromb Hemost; 1991 Apr; 17(2):94-8. PubMed ID: 1771418
    [Abstract] [Full Text] [Related]

  • 3. Structure-function relationships of the C-terminal functional domain of hirudin and its variants.
    Krstenansky JL, Mao SJ.
    Blood Coagul Fibrinolysis; 1991 Feb; 2(1):91-6. PubMed ID: 1773003
    [Abstract] [Full Text] [Related]

  • 4. Thrombin inhibition by hirudin: how hirudin inhibits thrombin.
    Fenton JW, Villanueva GB, Ofosu FA, Maraganore JM.
    Haemostasis; 1991 Feb; 21 Suppl 1():27-31. PubMed ID: 1894193
    [Abstract] [Full Text] [Related]

  • 5. Production, properties, and thrombin inhibitory mechanism of hirudin amino-terminal core fragments.
    Chang JY.
    J Biol Chem; 1990 Dec 25; 265(36):22159-66. PubMed ID: 2266119
    [Abstract] [Full Text] [Related]

  • 6. Use of fragments of hirudin to investigate thrombin-hirudin interaction.
    Dennis S, Wallace A, Hofsteenge J, Stone SR.
    Eur J Biochem; 1990 Feb 22; 188(1):61-6. PubMed ID: 2180697
    [Abstract] [Full Text] [Related]

  • 7. Mechanism of the inhibition of alpha-thrombin by hirudin-derived fragments hirudin(1-47) and hirudin(45-65).
    Schmitz T, Rothe M, Dodt J.
    Eur J Biochem; 1991 Jan 01; 195(1):251-6. PubMed ID: 1991472
    [Abstract] [Full Text] [Related]

  • 8. CX-397, a novel recombinant hirudin analog having a hybrid sequence of hirudin variants-1 and -3.
    Komatsu Y, Misawa S, Sukesada A, Ohba Y, Hayashi H.
    Biochem Biophys Res Commun; 1993 Oct 29; 196(2):773-9. PubMed ID: 8240353
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of thrombin by synthetic hirudin peptides.
    Binnie CG, Erickson BW, Hermans J.
    FEBS Lett; 1990 Sep 17; 270(1-2):85-9. PubMed ID: 2226793
    [Abstract] [Full Text] [Related]

  • 10. Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.
    De Filippis V, Colombo G, Russo I, Spadari B, Fontana A.
    Biochemistry; 2002 Nov 19; 41(46):13556-69. PubMed ID: 12427016
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of in vitro clot growth by r-hirudin is more effective and longer sustained than by an analogous peptide.
    Römisch J, Stöhr HA, Stauss H, Koschinsky R, Stüber W, Pâques EP.
    Thromb Haemost; 1994 Mar 19; 71(3):320-4. PubMed ID: 8029796
    [Abstract] [Full Text] [Related]

  • 12. Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding.
    Ayala YM, Vindigni A, Nayal M, Spolar RS, Record MT, Di Cera E.
    J Mol Biol; 1995 Nov 10; 253(5):787-98. PubMed ID: 7473752
    [Abstract] [Full Text] [Related]

  • 13. Stability of hirudin, a thrombin-specific inhibitor. The structure of alkaline-inactivated hirudin.
    Chang JY.
    J Biol Chem; 1991 Jun 15; 266(17):10839-43. PubMed ID: 2040604
    [Abstract] [Full Text] [Related]

  • 14. Kinetic mechanism for the interaction of Hirulog with thrombin.
    Parry MA, Maraganore JM, Stone SR.
    Biochemistry; 1994 Dec 13; 33(49):14807-14. PubMed ID: 7993908
    [Abstract] [Full Text] [Related]

  • 15. The hirudin-binding site of human alpha-thrombin. Identification of lysyl residues which participate in the combining site of hirudin-thrombin complex.
    Chang JY.
    J Biol Chem; 1989 May 05; 264(13):7141-6. PubMed ID: 2496126
    [Abstract] [Full Text] [Related]

  • 16. The structural elements of hirudin which bind to the fibrinogen recognition site of thrombin are exclusively located within its acidic C-terminal tail.
    Chang JY, Ngai PK, Rink H, Dennis S, Schlaeppi JM.
    FEBS Lett; 1990 Feb 26; 261(2):287-90. PubMed ID: 2107100
    [Abstract] [Full Text] [Related]

  • 17. Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity.
    Huang Y, Zhang Y, Zhao B, Xu Q, Zhou X, Song H, Yu M, Mo W.
    BMC Struct Biol; 2014 Dec 20; 14():26. PubMed ID: 25526801
    [Abstract] [Full Text] [Related]

  • 18. Deciphering the structural elements of hirudin C-terminal peptide that bind to the fibrinogen recognition site of alpha-thrombin.
    Chang JY.
    Biochemistry; 1991 Jul 09; 30(27):6656-61. PubMed ID: 2065053
    [Abstract] [Full Text] [Related]

  • 19. A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond.
    DiMaio J, Ni F, Gibbs B, Konishi Y.
    FEBS Lett; 1991 Apr 22; 282(1):47-52. PubMed ID: 2026264
    [Abstract] [Full Text] [Related]

  • 20. Probing the distance between the two binding sites of hirudin for its interaction with the active site and the fibrin(ogen)-binding site of alpha-thrombin.
    Wagner U, Schmitz T, Otte M, Dodt J.
    Biomed Biochim Acta; 1991 Apr 22; 50(4-6):707-10. PubMed ID: 1801747
    [Abstract] [Full Text] [Related]

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