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Journal Abstract Search

297 related items for PubMed ID: 18951411

  • 1. Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
    Sayer JM, Louis JM.
    Proteins; 2009 May 15; 75(3):556-68. PubMed ID: 18951411
    [Abstract] [Full Text] [Related]

  • 2. Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease.
    Sayer JM, Liu F, Ishima R, Weber IT, Louis JM.
    J Biol Chem; 2008 May 09; 283(19):13459-70. PubMed ID: 18281688
    [Abstract] [Full Text] [Related]

  • 3. Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.
    Shen CH, Wang YF, Kovalevsky AY, Harrison RW, Weber IT.
    FEBS J; 2010 Sep 09; 277(18):3699-714. PubMed ID: 20695887
    [Abstract] [Full Text] [Related]

  • 4. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
    Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT.
    J Mol Biol; 2008 Aug 01; 381(1):102-15. PubMed ID: 18597780
    [Abstract] [Full Text] [Related]

  • 5. Discovery of Novel HIV Protease Inhibitors Using Modern Computational Techniques.
    Okafor SN, Angsantikul P, Ahmed H.
    Int J Mol Sci; 2022 Oct 12; 23(20):. PubMed ID: 36293006
    [Abstract] [Full Text] [Related]

  • 6. Revealing the binding and drug resistance mechanism of amprenavir, indinavir, ritonavir, and nelfinavir complexed with HIV-1 protease due to double mutations G48T/L89M by molecular dynamics simulations and free energy analyses.
    Wang RG, Zhang HX, Zheng QC.
    Phys Chem Chem Phys; 2020 Feb 26; 22(8):4464-4480. PubMed ID: 32057044
    [Abstract] [Full Text] [Related]

  • 7. Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
    Tie Y, Wang YF, Boross PI, Chiu TY, Ghosh AK, Tozser J, Louis JM, Harrison RW, Weber IT.
    Protein Sci; 2012 Mar 26; 21(3):339-50. PubMed ID: 22238126
    [Abstract] [Full Text] [Related]

  • 8. Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS.
    Jayakanthan M, Chandrasekar S, Muthukumaran J, Mathur PP.
    J Mol Graph Model; 2010 Jan 26; 28(5):455-63. PubMed ID: 19931478
    [Abstract] [Full Text] [Related]

  • 9. A contribution to the drug resistance mechanism of darunavir, amprenavir, indinavir, and saquinavir complexes with HIV-1 protease due to flap mutation I50V: a systematic MM-PBSA and thermodynamic integration study.
    Leonis G, Steinbrecher T, Papadopoulos MG.
    J Chem Inf Model; 2013 Aug 26; 53(8):2141-53. PubMed ID: 23834142
    [Abstract] [Full Text] [Related]

  • 10. GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 variants in vitro.
    Amano M, Tojo Y, Salcedo-Gómez PM, Campbell JR, Das D, Aoki M, Xu CX, Rao KV, Ghosh AK, Mitsuya H.
    Antimicrob Agents Chemother; 2013 May 26; 57(5):2036-46. PubMed ID: 23403426
    [Abstract] [Full Text] [Related]

  • 11. High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.
    Choi SO, Rezk NL, Kashuba AD.
    J Pharm Biomed Anal; 2007 Mar 12; 43(4):1562-7. PubMed ID: 17236737
    [Abstract] [Full Text] [Related]

  • 12. Effects of drug-resistant mutations on the dynamic properties of HIV-1 protease and inhibition by Amprenavir and Darunavir.
    Yu Y, Wang J, Shao Q, Shi J, Zhu W.
    Sci Rep; 2015 May 27; 5():10517. PubMed ID: 26012849
    [Abstract] [Full Text] [Related]

  • 13. Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
    Tie Y, Boross PI, Wang YF, Gaddis L, Liu F, Chen X, Tozser J, Harrison RW, Weber IT.
    FEBS J; 2005 Oct 27; 272(20):5265-77. PubMed ID: 16218957
    [Abstract] [Full Text] [Related]

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  • 15. Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant.
    Todd MJ, Luque I, Velázquez-Campoy A, Freire E.
    Biochemistry; 2000 Oct 03; 39(39):11876-83. PubMed ID: 11009599
    [Abstract] [Full Text] [Related]

  • 16. Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
    Mittal S, Bandaranayake RM, King NM, Prabu-Jeyabalan M, Nalam MN, Nalivaika EA, Yilmaz NK, Schiffer CA.
    J Virol; 2013 Apr 03; 87(8):4176-84. PubMed ID: 23365446
    [Abstract] [Full Text] [Related]

  • 17. Structure, dynamics and solvation of HIV-1 protease/saquinavir complex in aqueous solution and their contributions to drug resistance: molecular dynamic simulations.
    Wittayanarakul K, Aruksakunwong O, Sompornpisut P, Sanghiran-Lee V, Parasuk V, Pinitglang S, Hannongbua S.
    J Chem Inf Model; 2005 Apr 03; 45(2):300-8. PubMed ID: 15807491
    [Abstract] [Full Text] [Related]

  • 18. Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavir.
    Kagan RM, Shenderovich MD, Heseltine PN, Ramnarayan K.
    Protein Sci; 2005 Jul 03; 14(7):1870-8. PubMed ID: 15937277
    [Abstract] [Full Text] [Related]

  • 19. Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS.
    Chi J, Jayewardene AL, Stone JA, Motoya T, Aweeka FT.
    J Pharm Biomed Anal; 2002 Oct 15; 30(3):675-84. PubMed ID: 12367693
    [Abstract] [Full Text] [Related]

  • 20. Exploring molecular mechanism of allosteric inhibitor to relieve drug resistance of multiple mutations in HIV-1 protease by enhanced conformational sampling.
    Chen J, Peng C, Wang J, Zhu W.
    Proteins; 2018 Dec 15; 86(12):1294-1305. PubMed ID: 30260044
    [Abstract] [Full Text] [Related]

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