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Journal Abstract Search

223 related items for PubMed ID: 18952442

  • 1. Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.
    Alvarado M, Goya P, Macías-González M, Pavón FJ, Serrano A, Jagerovic N, Elguero J, Gutiérrez-Rodríguez A, García-Granda S, Suardíaz M, Rodríguez de Fonseca F.
    Bioorg Med Chem; 2008 Dec 01; 16(23):10098-105. PubMed ID: 18952442
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties.
    Almeida B, Joglar J, Luque Rojas MJ, Decara JM, Bermúdez-Silva FJ, Macias-González M, Fitó M, Romero-Cuevas M, Farré M, Covas MI, Rodríguez de Fonseca F, de la Torre R.
    ChemMedChem; 2010 Oct 04; 5(10):1781-7. PubMed ID: 20718074
    [Abstract] [Full Text] [Related]

  • 3. Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.
    Alvarado M, Decara J, Luque MJ, Hernandez-Folgado L, Gómez-Cañas M, Gómez-Ruiz M, Fernández-Ruiz J, Elguero J, Jagerovic N, Serrano A, Goya P, de Fonseca FR.
    Bioorg Med Chem; 2013 Apr 01; 21(7):1708-16. PubMed ID: 23434135
    [Abstract] [Full Text] [Related]

  • 4. Oxadiazole-diarylpyrazole 4-carboxamides as cannabinoid CB1 receptor ligands.
    Lee SH, Seo HJ, Kim MJ, Kang SY, Song KS, Lee SH, Jung ME, Kim J, Lee J.
    Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1899-902. PubMed ID: 19269817
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
    Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Lavecchia A, Brizzi A, Pasquini S, Allarà M, Fantini N, Carai MA, Bigogno C, Rozio MG, Sinisi R, Novellino E, Colombo G, Di Marzo V, Dondio G, Corelli F.
    Eur J Med Chem; 2010 Dec 01; 45(12):5878-86. PubMed ID: 20943290
    [Abstract] [Full Text] [Related]

  • 6. Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists.
    Szabó G, Varga B, Páyer-Lengyel D, Szemzo A, Erdélyi P, Vukics K, Szikra J, Hegyi E, Vastag M, Kiss B, Laszy J, Gyertyán I, Fischer J.
    J Med Chem; 2009 Jul 23; 52(14):4329-37. PubMed ID: 19527048
    [Abstract] [Full Text] [Related]

  • 7. Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists.
    Kajita D, Nakamura M, Matsumoto Y, Ishikawa M, Hashimoto Y, Fujii S.
    Bioorg Med Chem Lett; 2015 Aug 15; 25(16):3350-4. PubMed ID: 26071639
    [Abstract] [Full Text] [Related]

  • 8. Unsaturated fatty alcohol derivatives of olive oil phenolic compounds with potential low-density lipoprotein (LDL) antioxidant and antiobesity properties.
    Cotrim BA, Joglar J, Rojas MJ, del Olmo JM, Macias-González M, Cuevas MR, Fitó M, Muñoz-Aguayo D, Planells MI, Farré M, de Fonseca FR, de la Torre R.
    J Agric Food Chem; 2012 Feb 01; 60(4):1067-74. PubMed ID: 22220510
    [Abstract] [Full Text] [Related]

  • 9. Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
    Zhu C, Hansen AR, Bateman T, Chen Z, Holt TG, Hubert JA, Karanam BV, Lee SJ, Pan J, Qian S, Reddy VB, Reitman ML, Strack AM, Tong V, Weingarth DT, Wolff MS, MacNeil DJ, Weber AE, Duffy JL, Edmondson SD.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4393-6. PubMed ID: 18614364
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and evaluation of fatty acid amides on the N-oleoylethanolamide-like activation of peroxisome proliferator activated receptor α.
    Takao K, Noguchi K, Hashimoto Y, Shirahata A, Sugita Y.
    Chem Pharm Bull (Tokyo); 2015 Aug 01; 63(4):278-85. PubMed ID: 25832022
    [Abstract] [Full Text] [Related]

  • 11. Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists.
    Lange JH, van der Neut MA, den Hartog AP, Wals HC, Hoogendoorn J, van Stuivenberg HH, van Vliet BJ, Kruse CG.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1752-7. PubMed ID: 20137935
    [Abstract] [Full Text] [Related]

  • 12. Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood-brain-barrier.
    Receveur JM, Murray A, Linget JM, Nørregaard PK, Cooper M, Bjurling E, Nielsen PA, Högberg T.
    Bioorg Med Chem Lett; 2010 Jan 15; 20(2):453-7. PubMed ID: 20015647
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological evaluation of new flavonoid fatty acid esters with anti-adipogenic and enhancing glucose consumption activities.
    Zhao W, Sun J, Xiang H, Zeng YY, Li XB, Xiao H, Chen DY, Ma RL.
    Bioorg Med Chem; 2011 May 15; 19(10):3192-203. PubMed ID: 21515060
    [Abstract] [Full Text] [Related]

  • 14. Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: synthesis, biological evaluation, and molecular modeling in the homology model.
    Srivastava BK, Joharapurkar A, Raval S, Patel JZ, Soni R, Raval P, Gite A, Goswami A, Sadhwani N, Gandhi N, Patel H, Mishra B, Solanki M, Pandey B, Jain MR, Patel PR.
    J Med Chem; 2007 Nov 29; 50(24):5951-66. PubMed ID: 17979261
    [Abstract] [Full Text] [Related]

  • 15. Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
    Lin LS, Lanza TJ, Jewell JP, Liu P, Shah SK, Qi H, Tong X, Wang J, Xu SS, Fong TM, Shen CP, Lao J, Xiao JC, Shearman LP, Stribling DS, Rosko K, Strack A, Marsh DJ, Feng Y, Kumar S, Samuel K, Yin W, Van der Ploeg LH, Goulet MT, Hagmann WK.
    J Med Chem; 2006 Dec 28; 49(26):7584-7. PubMed ID: 17181138
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.
    J Med Chem; 2008 Oct 23; 51(20):6318-33. PubMed ID: 18826205
    [Abstract] [Full Text] [Related]

  • 17. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.
    Moulin A, Demange L, Ryan J, Mousseaux D, Sanchez P, Bergé G, Gagne D, Perrissoud D, Locatelli V, Torsello A, Galleyrand JC, Fehrentz JA, Martinez J.
    J Med Chem; 2008 Feb 14; 51(3):689-93. PubMed ID: 18193826
    [Abstract] [Full Text] [Related]

  • 18. Differential effects of in vivo PPAR alpha and gamma activation on fatty acid transport proteins expression and lipid content in rat liver.
    Wierzbicki M, Chabowski A, Zendzian-Piotrowska M, Gorski J.
    J Physiol Pharmacol; 2009 Mar 14; 60(1):99-106. PubMed ID: 19439812
    [Abstract] [Full Text] [Related]

  • 19. Fatty acid synthesis and PPARalpha hand in hand.
    Rotman N, Wahli W.
    Chem Biol; 2009 Aug 28; 16(8):801-2. PubMed ID: 19716470
    [Abstract] [Full Text] [Related]

  • 20. The discovery of equipotent PPARalpha/gamma dual activators.
    Martres P, Faucher N, Laroze A, Pineau O, Fouchet MH, Potvain F, Grillot D, Beneton V.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6251-4. PubMed ID: 18947994
    [Abstract] [Full Text] [Related]

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