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Journal Abstract Search

321 related items for PubMed ID: 18954983

  • 21. 4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.
    Fréchette S, Leit S, Woo SH, Lapointe G, Jeannotte G, Moradei O, Paquin I, Bouchain G, Raeppel S, Gaudette F, Zhou N, Vaisburg A, Fournel M, Yan PT, Trachy-Bourget MC, Kalita A, Robert MF, Lu A, Rahil J, Robert Macleod A, Besterman JM, Li Z, Delorme D.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1502-6. PubMed ID: 18207391
    [Abstract] [Full Text] [Related]

  • 22. N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
    Remiszewski SW, Sambucetti LC, Bair KW, Bontempo J, Cesarz D, Chandramouli N, Chen R, Cheung M, Cornell-Kennon S, Dean K, Diamantidis G, France D, Green MA, Howell KL, Kashi R, Kwon P, Lassota P, Martin MS, Mou Y, Perez LB, Sharma S, Smith T, Sorensen E, Taplin F, Trogani N, Versace R, Walker H, Weltchek-Engler S, Wood A, Wu A, Atadja P.
    J Med Chem; 2003 Oct 09; 46(21):4609-24. PubMed ID: 14521422
    [Abstract] [Full Text] [Related]

  • 23. Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.
    Engel D, Nudelman A, Tarasenko N, Levovich I, Makarovsky I, Sochotnikov S, Tarasenko I, Rephaeli A.
    J Med Chem; 2008 Jan 24; 51(2):314-23. PubMed ID: 18163551
    [Abstract] [Full Text] [Related]

  • 24. Structure-activity relationship studies of a series of novel delta-lactam-based histone deacetylase inhibitors.
    Kim HM, Ryu DK, Choi Y, Park BW, Lee K, Han SB, Lee CW, Kang MR, Kang JS, Boovanahalli SK, Park SK, Han JW, Chun TG, Lee HY, Nam KY, Choi EH, Han G.
    J Med Chem; 2007 May 31; 50(11):2737-41. PubMed ID: 17477518
    [Abstract] [Full Text] [Related]

  • 25. Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents.
    Guandalini L, Cellai C, Laurenzana A, Scapecchi S, Paoletti F, Romanelli MN.
    Bioorg Med Chem Lett; 2008 Sep 15; 18(18):5071-4. PubMed ID: 18723349
    [Abstract] [Full Text] [Related]

  • 26. HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.
    Wegener D, Deubzer HE, Oehme I, Milde T, Hildmann C, Schwienhorst A, Witt O.
    Anticancer Drugs; 2008 Oct 15; 19(9):849-57. PubMed ID: 18765999
    [Abstract] [Full Text] [Related]

  • 27. Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.
    Hanessian S, Auzzas L, Giannini G, Marzi M, Cabri W, Barbarino M, Vesci L, Pisano C.
    Bioorg Med Chem Lett; 2007 Nov 15; 17(22):6261-5. PubMed ID: 17892933
    [Abstract] [Full Text] [Related]

  • 28. Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives.
    Suzuki T, Ando T, Tsuchiya K, Fukazawa N, Saito A, Mariko Y, Yamashita T, Nakanishi O.
    J Med Chem; 1999 Jul 29; 42(15):3001-3. PubMed ID: 10425110
    [Abstract] [Full Text] [Related]

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  • 30. Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
    Kasibhatla SR, Hong K, Biamonte MA, Busch DJ, Karjian PL, Sensintaffar JL, Kamal A, Lough RE, Brekken J, Lundgren K, Grecko R, Timony GA, Ran Y, Mansfield R, Fritz LC, Ulm E, Burrows FJ, Boehm MF.
    J Med Chem; 2007 Jun 14; 50(12):2767-78. PubMed ID: 17488003
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  • 32. Design and campaign synthesis of pyridine-based histone deacetylase inhibitors.
    Andrews DM, Gibson KM, Graham MA, Matusiak ZS, Roberts CA, Stokes ES, Brady MC, Chresta CM.
    Bioorg Med Chem Lett; 2008 Apr 15; 18(8):2525-9. PubMed ID: 18378451
    [Abstract] [Full Text] [Related]

  • 33. Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents.
    Hu L, Li ZR, Wang YM, Wu Y, Jiang JD, Boykin DW.
    Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1193-6. PubMed ID: 17197178
    [Abstract] [Full Text] [Related]

  • 34. Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
    Ontoria JM, Altamura S, Di Marco A, Ferrigno F, Laufer R, Muraglia E, Palumbi MC, Rowley M, Scarpelli R, Schultz-Fademrecht C, Serafini S, Steinkühler C, Jones P.
    J Med Chem; 2009 Nov 12; 52(21):6782-9. PubMed ID: 19888759
    [Abstract] [Full Text] [Related]

  • 35. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
    Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J, Coleman K, Yao L, Martinez-Alsina L, Lorenzen M, Berliner M, Luzzio M, Patel N, Schmitt E, LaGreca S, Jani J, Wessel M, Marr E, Griffor M, Vajdos F.
    Cancer Res; 2008 Mar 15; 68(6):1935-44. PubMed ID: 18339875
    [Abstract] [Full Text] [Related]

  • 36. Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases.
    Lee HY, Wang LT, Li YH, Pan SL, Chen YL, Teng CM, Liou JP.
    Org Biomol Chem; 2014 Nov 28; 12(44):8966-76. PubMed ID: 25277250
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  • 38. Structure-activity relationship of alkyl 9-nitrocamptothecin esters.
    Cao ZS, Pantazis P, Mendoza J, Early J, Kozielski A, Harris N, Giovanella B.
    Acta Pharmacol Sin; 2003 Feb 28; 24(2):109-19. PubMed ID: 12546717
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