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Journal Abstract Search

623 related items for PubMed ID: 18980964

  • 1. Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors.
    Chen FL, Xia W, Spector NL.
    Clin Cancer Res; 2008 Nov 01; 14(21):6730-4. PubMed ID: 18980964
    [Abstract] [Full Text] [Related]

  • 2. Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers.
    Xia W, Bisi J, Strum J, Liu L, Carrick K, Graham KM, Treece AL, Hardwicke MA, Dush M, Liao Q, Westlund RE, Zhao S, Bacus S, Spector NL.
    Cancer Res; 2006 Feb 01; 66(3):1640-7. PubMed ID: 16452223
    [Abstract] [Full Text] [Related]

  • 3. Lapatinib: a small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor-2 tyrosine kinases used in the treatment of breast cancer.
    Tevaarwerk AJ, Kolesar JM.
    Clin Ther; 2009 Feb 01; 31 Pt 2():2332-48. PubMed ID: 20110044
    [Abstract] [Full Text] [Related]

  • 4. Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.
    Xia W, Gerard CM, Liu L, Baudson NM, Ory TL, Spector NL.
    Oncogene; 2005 Sep 15; 24(41):6213-21. PubMed ID: 16091755
    [Abstract] [Full Text] [Related]

  • 5. Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases.
    Medina PJ, Goodin S.
    Clin Ther; 2008 Aug 15; 30(8):1426-47. PubMed ID: 18803986
    [Abstract] [Full Text] [Related]

  • 6. The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer.
    Chu I, Blackwell K, Chen S, Slingerland J.
    Cancer Res; 2005 Jan 01; 65(1):18-25. PubMed ID: 15665275
    [Abstract] [Full Text] [Related]

  • 7. EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.
    Trowe T, Boukouvala S, Calkins K, Cutler RE, Fong R, Funke R, Gendreau SB, Kim YD, Miller N, Woolfrey JR, Vysotskaia V, Yang JP, Gerritsen ME, Matthews DJ, Lamb P, Heuer TS.
    Clin Cancer Res; 2008 Apr 15; 14(8):2465-75. PubMed ID: 18413839
    [Abstract] [Full Text] [Related]

  • 8. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas.
    Burris HA, Hurwitz HI, Dees EC, Dowlati A, Blackwell KL, O'Neil B, Marcom PK, Ellis MJ, Overmoyer B, Jones SF, Harris JL, Smith DA, Koch KM, Stead A, Mangum S, Spector NL.
    J Clin Oncol; 2005 Aug 10; 23(23):5305-13. PubMed ID: 15955900
    [Abstract] [Full Text] [Related]

  • 9. An overview of HER-targeted therapy with lapatinib in breast cancer.
    McArthur H.
    Adv Ther; 2009 Mar 10; 26(3):263-71. PubMed ID: 19365626
    [Abstract] [Full Text] [Related]

  • 10. Autophagy facilitates the Lapatinib resistance of HER2 positive breast cancer cells.
    Chen S, Li X, Feng J, Chang Y, Wang Z, Wen A.
    Med Hypotheses; 2011 Aug 10; 77(2):206-8. PubMed ID: 21570197
    [Abstract] [Full Text] [Related]

  • 11.
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  • 12. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.
    Jani JP, Finn RS, Campbell M, Coleman KG, Connell RD, Currier N, Emerson EO, Floyd E, Harriman S, Kath JC, Morris J, Moyer JD, Pustilnik LR, Rafidi K, Ralston S, Rossi AM, Steyn SJ, Wagner L, Winter SM, Bhattacharya SK.
    Cancer Res; 2007 Oct 15; 67(20):9887-93. PubMed ID: 17942920
    [Abstract] [Full Text] [Related]

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  • 14. Inhibition of c-ABL sensitizes breast cancer cells to the dual ErbB receptor tyrosine kinase inhibitor lapatinib (GW572016).
    Lo YH, Ho PC, Zhao H, Wang SC.
    Anticancer Res; 2011 Mar 15; 31(3):789-95. PubMed ID: 21498698
    [Abstract] [Full Text] [Related]

  • 15. Target-based therapies in breast cancer: current status and future perspectives.
    Normanno N, Morabito A, De Luca A, Piccirillo MC, Gallo M, Maiello MR, Perrone F.
    Endocr Relat Cancer; 2009 Sep 15; 16(3):675-702. PubMed ID: 19525314
    [Abstract] [Full Text] [Related]

  • 16. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.
    Xia W, Bacus S, Hegde P, Husain I, Strum J, Liu L, Paulazzo G, Lyass L, Trusk P, Hill J, Harris J, Spector NL.
    Proc Natl Acad Sci U S A; 2006 May 16; 103(20):7795-800. PubMed ID: 16682622
    [Abstract] [Full Text] [Related]

  • 17. Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor.
    Witters LM, Witkoski A, Planas-Silva MD, Berger M, Viallet J, Lipton A.
    Oncol Rep; 2007 Feb 16; 17(2):465-9. PubMed ID: 17203189
    [Abstract] [Full Text] [Related]

  • 18. Peptide aptamers with binding specificity for the intracellular domain of the ErbB2 receptor interfere with AKT signaling and sensitize breast cancer cells to Taxol.
    Kunz C, Borghouts C, Buerger C, Groner B.
    Mol Cancer Res; 2006 Dec 16; 4(12):983-98. PubMed ID: 17189388
    [Abstract] [Full Text] [Related]

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  • 20. Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
    Emanuel SL, Hughes TV, Adams M, Rugg CA, Fuentes-Pesquera A, Connolly PJ, Pandey N, Moreno-Mazza S, Butler J, Borowski V, Middleton SA, Gruninger RH, Story JR, Napier C, Hollister B, Greenberger LM.
    Mol Pharmacol; 2008 Feb 16; 73(2):338-48. PubMed ID: 17975007
    [Abstract] [Full Text] [Related]

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