These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

182 related items for PubMed ID: 18983139

  • 1. cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR, Strakhova MI, Vortherms TA, Wakefield BD, Wetter JM, Witte DG, Honore P, Esbenshade TA, Brioni JD, Cowart MD.
    J Med Chem; 2008 Nov 27; 51(22):7094-8. PubMed ID: 18983139
    [Abstract] [Full Text] [Related]

  • 2. H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats.
    Hsieh GC, Chandran P, Salyers AK, Pai M, Zhu CZ, Wensink EJ, Witte DG, Miller TR, Mikusa JP, Baker SJ, Wetter JM, Marsh KC, Hancock AA, Cowart MD, Esbenshade TA, Brioni JD, Honore P.
    Pharmacol Biochem Behav; 2010 Mar 27; 95(1):41-50. PubMed ID: 20004681
    [Abstract] [Full Text] [Related]

  • 3. INCB38579, a novel and potent histamine H₄ receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions.
    Shin N, Covington M, Bian D, Zhuo J, Bowman K, Li Y, Soloviev M, Qian DQ, Feldman P, Leffet L, He X, He Wang K, Krug K, Bell D, Czerniak P, Hu Z, Zhao H, Zhang J, Yeleswaram S, Yao W, Newton R, Scherle P.
    Eur J Pharmacol; 2012 Jan 30; 675(1-3):47-56. PubMed ID: 22155710
    [Abstract] [Full Text] [Related]

  • 4. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
    Cowart MD, Altenbach RJ, Liu H, Hsieh GC, Drizin I, Milicic I, Miller TR, Witte DG, Wishart N, Fix-Stenzel SR, McPherson MJ, Adair RM, Wetter JM, Bettencourt BM, Marsh KC, Sullivan JP, Honore P, Esbenshade TA, Brioni JD.
    J Med Chem; 2008 Oct 23; 51(20):6547-57. PubMed ID: 18817367
    [Abstract] [Full Text] [Related]

  • 5. Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
    Hawkinson JE, Szoke BG, Garofalo AW, Hom DS, Zhang H, Dreyer M, Fukuda JY, Chen L, Samant B, Simmonds S, Zeitz KP, Wadsworth A, Liao A, Chavez RA, Zmolek W, Ruslim L, Bova MP, Holcomb R, Butelman ER, Ko MC, Malmberg AB.
    J Pharmacol Exp Ther; 2007 Aug 23; 322(2):619-30. PubMed ID: 17470643
    [Abstract] [Full Text] [Related]

  • 6. Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.
    Smits RA, Lim HD, Hanzer A, Zuiderveld OP, Guaita E, Adami M, Coruzzi G, Leurs R, de Esch IJ.
    J Med Chem; 2008 Apr 24; 51(8):2457-67. PubMed ID: 18357976
    [Abstract] [Full Text] [Related]

  • 7. Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
    Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, El-Kouhen OF, Miller LN, Li L, Yao BB, Hsieh GC, Pai M, Zhu CZ, Chandran P, Meyer MD.
    J Med Chem; 2008 Mar 27; 51(6):1904-12. PubMed ID: 18311894
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists.
    Smits RA, Adami M, Istyastono EP, Zuiderveld OP, van Dam CM, de Kanter FJ, Jongejan A, Coruzzi G, Leurs R, de Esch IJ.
    J Med Chem; 2010 Mar 25; 53(6):2390-400. PubMed ID: 20192225
    [Abstract] [Full Text] [Related]

  • 9. Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity.
    Abouzid K, Bekhit SA.
    Bioorg Med Chem; 2008 May 15; 16(10):5547-56. PubMed ID: 18430576
    [Abstract] [Full Text] [Related]

  • 10. Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
    Smits RA, Lim HD, van der Meer T, Kuhne S, Bessembinder K, Zuiderveld OP, Wijtmans M, de Esch IJ, Leurs R.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):461-7. PubMed ID: 22153663
    [Abstract] [Full Text] [Related]

  • 11. Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach.
    Smits RA, de Esch IJ, Zuiderveld OP, Broeker J, Sansuk K, Guaita E, Coruzzi G, Adami M, Haaksma E, Leurs R.
    J Med Chem; 2008 Dec 25; 51(24):7855-65. PubMed ID: 19053770
    [Abstract] [Full Text] [Related]

  • 12. Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines.
    Yokoyama K, Ishikawa N, Igarashi S, Kawano N, Masuda N, Hattori K, Miyazaki T, Ogino S, Orita M, Matsumoto Y, Takeuchi M, Ohta M.
    Bioorg Med Chem; 2008 Sep 01; 16(17):7968-74. PubMed ID: 18694645
    [Abstract] [Full Text] [Related]

  • 13. The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine.
    Favre-Guilmard C, Zeroual-Hider H, Soulard C, Touvay C, Chabrier PE, Prevost G, Auguet M.
    Eur J Pharmacol; 2008 Oct 10; 594(1-3):70-6. PubMed ID: 18664366
    [Abstract] [Full Text] [Related]

  • 14. Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
    Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG.
    J Med Chem; 2008 Mar 27; 51(6):1637-48. PubMed ID: 18278858
    [Abstract] [Full Text] [Related]

  • 15. Chemical and biological investigation of N-hydroxy-valdecoxib: An active metabolite of valdecoxib.
    Erdélyi P, Fodor T, Varga AK, Czugler M, Gere A, Fischer J.
    Bioorg Med Chem; 2008 May 01; 16(9):5322-30. PubMed ID: 18353655
    [Abstract] [Full Text] [Related]

  • 16. Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: synthesis and their anti-inflammatory and analgesic activities.
    Akhter M, Husain A, Azad B, Ajmal M.
    Eur J Med Chem; 2009 Jun 01; 44(6):2372-8. PubMed ID: 18977556
    [Abstract] [Full Text] [Related]

  • 17. Synthesis, analgesic and anti-inflammatory evaluation of some new 3H-quinazolin-4-one derivatives.
    Alafeefy AM, Kadi AA, El-Azab AS, Abdel-Hamide SG, Daba MH.
    Arch Pharm (Weinheim); 2008 Jun 01; 341(6):377-85. PubMed ID: 18535995
    [Abstract] [Full Text] [Related]

  • 18. Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.
    Kym PR, Kort ME, Coghlan MJ, Moore JL, Tang R, Ratajczyk JD, Larson DP, Elmore SW, Pratt JK, Stashko MA, Falls HD, Lin CW, Nakane M, Miller L, Tyree CM, Miner JN, Jacobson PB, Wilcox DM, Nguyen P, Lane BC.
    J Med Chem; 2003 Mar 13; 46(6):1016-30. PubMed ID: 12620078
    [Abstract] [Full Text] [Related]

  • 19. Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats.
    Richebé P, Rivalan B, Rivat C, Laulin JP, Janvier G, Maurette P, Simonnet G.
    Can J Anaesth; 2009 Feb 13; 56(2):126-35. PubMed ID: 19247760
    [Abstract] [Full Text] [Related]

  • 20. Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
    Altenbach RJ, Adair RM, Bettencourt BM, Black LA, Fix-Stenzel SR, Gopalakrishnan SM, Hsieh GC, Liu H, Marsh KC, McPherson MJ, Milicic I, Miller TR, Vortherms TA, Warrior U, Wetter JM, Wishart N, Witte DG, Honore P, Esbenshade TA, Hancock AA, Brioni JD, Cowart MD.
    J Med Chem; 2008 Oct 23; 51(20):6571-80. PubMed ID: 18811133
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 10.