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Journal Abstract Search

566 related items for PubMed ID: 18984007

  • 1. Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.
    Samuele A, Kataropoulou A, Viola M, Zanoli S, La Regina G, Piscitelli F, Silvestri R, Maga G.
    Antiviral Res; 2009 Jan; 81(1):47-55. PubMed ID: 18984007
    [Abstract] [Full Text] [Related]

  • 2. High potency of indolyl aryl sulfone nonnucleoside inhibitors towards drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutants is due to selective targeting of different mechanistic forms of the enzyme.
    Cancio R, Silvestri R, Ragno R, Artico M, De Martino G, La Regina G, Crespan E, Zanoli S, Hübscher U, Spadari S, Maga G.
    Antimicrob Agents Chemother; 2005 Nov; 49(11):4546-54. PubMed ID: 16251294
    [Abstract] [Full Text] [Related]

  • 3. Mechanism of interaction of novel indolylarylsulfone derivatives with K103N and Y181I mutant HIV-1 reverse transcriptase in complex with its substrates.
    Samuele A, Bisi S, Kataropoulou A, La Regina G, Piscitelli F, Gatti V, Silvestri R, Maga G.
    Antivir Chem Chemother; 2011 Nov 17; 22(3):107-18. PubMed ID: 22095519
    [Abstract] [Full Text] [Related]

  • 4. Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
    Piscitelli F, Coluccia A, Brancale A, La Regina G, Sansone A, Giordano C, Balzarini J, Maga G, Zanoli S, Samuele A, Cirilli R, La Torre F, Lavecchia A, Novellino E, Silvestri R.
    J Med Chem; 2009 Apr 09; 52(7):1922-34. PubMed ID: 19281225
    [Abstract] [Full Text] [Related]

  • 5. Indolyl aryl sulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: role of two halogen atoms at the indole ring in developing new analogues with improved antiviral activity.
    Regina GL, Coluccia A, Piscitelli F, Bergamini A, Sinistro A, Cavazza A, Maga G, Samuele A, Zanoli S, Novellino E, Artico M, Silvestri R.
    J Med Chem; 2007 Oct 04; 50(20):5034-8. PubMed ID: 17803291
    [Abstract] [Full Text] [Related]

  • 6. Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.
    Ragno R, Artico M, De Martino G, La Regina G, Coluccia A, Di Pasquali A, Silvestri R.
    J Med Chem; 2005 Jan 13; 48(1):213-23. PubMed ID: 15634015
    [Abstract] [Full Text] [Related]

  • 7. Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
    Silvestri R, De Martino G, La Regina G, Artico M, Massa S, Vargiu L, Mura M, Loi AG, Marceddu T, La Colla P.
    J Med Chem; 2003 Jun 05; 46(12):2482-93. PubMed ID: 12773052
    [Abstract] [Full Text] [Related]

  • 8. Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
    Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR.
    J Med Chem; 2004 Feb 26; 47(5):1175-82. PubMed ID: 14971897
    [Abstract] [Full Text] [Related]

  • 9. Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
    Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK.
    J Med Chem; 2004 Nov 18; 47(24):5912-22. PubMed ID: 15537346
    [Abstract] [Full Text] [Related]

  • 10. Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.
    Zhang Z, Walker M, Xu W, Shim JH, Girardet JL, Hamatake RK, Hong Z.
    Antimicrob Agents Chemother; 2006 Aug 18; 50(8):2772-81. PubMed ID: 16870771
    [Abstract] [Full Text] [Related]

  • 11. Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants.
    Cancio R, Mai A, Rotili D, Artico M, Sbardella G, Clotet-Codina I, Esté JA, Crespan E, Zanoli S, Hübscher U, Spadari S, Maga G.
    ChemMedChem; 2007 Apr 18; 2(4):445-8. PubMed ID: 17323401
    [No Abstract] [Full Text] [Related]

  • 12. Understanding the basis of resistance in the irksome Lys103Asn HIV-1 reverse transcriptase mutant through targeted molecular dynamics simulations.
    Rodríguez-Barrios F, Gago F.
    J Am Chem Soc; 2004 Dec 01; 126(47):15386-7. PubMed ID: 15563158
    [Abstract] [Full Text] [Related]

  • 13. Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
    Himmel DM, Das K, Clark AD, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E.
    J Med Chem; 2005 Dec 01; 48(24):7582-91. PubMed ID: 16302798
    [Abstract] [Full Text] [Related]

  • 14. Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations.
    Silvestri R, Artico M, De Martino G, La Regina G, Loddo R, La Colla M, Mura M, La Colla P.
    J Med Chem; 2004 Jul 15; 47(15):3892-6. PubMed ID: 15239667
    [Abstract] [Full Text] [Related]

  • 15. Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
    Butini S, Gemma S, Brindisi M, Borrelli G, Fiorini I, Samuele A, Karytinos A, Facchini M, Lossani A, Zanoli S, Campiani G, Novellino E, Focher F, Maga G.
    Bioorg Med Chem Lett; 2011 Jul 01; 21(13):3935-8. PubMed ID: 21636271
    [Abstract] [Full Text] [Related]

  • 16. Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
    Butini S, Brindisi M, Cosconati S, Marinelli L, Borrelli G, Coccone SS, Ramunno A, Campiani G, Novellino E, Zanoli S, Samuele A, Giorgi G, Bergamini A, Di Mattia M, Lalli S, Galletti B, Gemma S, Maga G.
    J Med Chem; 2009 Feb 26; 52(4):1224-8. PubMed ID: 19170521
    [Abstract] [Full Text] [Related]

  • 17. The effect of NNRTIs on HIV reverse transcriptase dimerization.
    Tachedjian G, Goff SP.
    Curr Opin Investig Drugs; 2003 Aug 26; 4(8):966-73. PubMed ID: 14508881
    [Abstract] [Full Text] [Related]

  • 18. 2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Rao A, Balzarini J, Carbone A, Chimirri A, De Clercq E, Monforte AM, Monforte P, Pannecouque C, Zappalà M.
    Antiviral Res; 2004 Aug 26; 63(2):79-84. PubMed ID: 15302136
    [Abstract] [Full Text] [Related]

  • 19. Diphenyl ether non-nucleoside reverse transcriptase inhibitors with excellent potency against resistant mutant viruses and promising pharmacokinetic properties.
    Sweeney ZK, Kennedy-Smith JJ, Wu J, Arora N, Billedeau JR, Davidson JP, Fretland J, Hang JQ, Heilek GM, Harris SF, Hirschfeld D, Inbar P, Javanbakht H, Jernelius JA, Jin Q, Li Y, Liang W, Roetz R, Sarma K, Smith M, Stefanidis D, Su G, Suh JM, Villaseñor AG, Welch M, Zhang FJ, Klumpp K.
    ChemMedChem; 2009 Jan 26; 4(1):88-99. PubMed ID: 19006142
    [Abstract] [Full Text] [Related]

  • 20. Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
    Fattorusso C, Gemma S, Butini S, Huleatt P, Catalanotti B, Persico M, De Angelis M, Fiorini I, Nacci V, Ramunno A, Rodriquez M, Greco G, Novellino E, Bergamini A, Marini S, Coletta M, Maga G, Spadari S, Campiani G.
    J Med Chem; 2005 Nov 17; 48(23):7153-65. PubMed ID: 16279773
    [Abstract] [Full Text] [Related]

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