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Journal Abstract Search

122 related items for PubMed ID: 1899453

  • 1. On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.
    Selassie CD, Li RL, Poe M, Hansch C.
    J Med Chem; 1991 Jan; 34(1):46-54. PubMed ID: 1899453
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  • 2. Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis.
    Hansch C, Li R, Blaney JM, Langridge R.
    J Med Chem; 1982 Jul; 25(7):777-84. PubMed ID: 6809941
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  • 3. Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase.
    Selassie CD, Gan WX, Kallander LS, Klein TE.
    J Med Chem; 1998 Oct 22; 41(22):4261-72. PubMed ID: 9784101
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  • 4. Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines.
    Li RL, Dietrich SW, Hansch C.
    J Med Chem; 1981 May 22; 24(5):538-44. PubMed ID: 7017146
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  • 5. On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
    Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT.
    J Med Chem; 1989 Aug 22; 32(8):1895-905. PubMed ID: 2502631
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  • 14. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS.
    Rosowsky A, Forsch RA, Queener SF.
    J Med Chem; 2003 Apr 24; 46(9):1726-36. PubMed ID: 12699390
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  • 15. Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
    Hansch C, Hathaway BA, Guo ZR, Selassie CD, Dietrich SW, Blaney JM, Langridge R, Volz KW, Kaufman BT.
    J Med Chem; 1984 Feb 24; 27(2):129-43. PubMed ID: 6420569
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  • 18. 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase.
    Johnson JV, Rauchman BS, Baccanari DP, Roth B.
    J Med Chem; 1989 Aug 24; 32(8):1942-9. PubMed ID: 2666668
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