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282 related items for PubMed ID: 19004816

  • 1. Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
    Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP.
    J Biol Chem; 2009 Jan 30; 284(5):2598-2602. PubMed ID: 19004816
    [Abstract] [Full Text] [Related]

  • 2. In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 α-synuclein phosphorylation in mouse brain.
    Bergeron M, Motter R, Tanaka P, Fauss D, Babcock M, Chiou SS, Nelson S, San Pablo F, Anderson JP.
    Neuroscience; 2014 Jan 03; 256():72-82. PubMed ID: 24128992
    [Abstract] [Full Text] [Related]

  • 3. Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.
    Weston LJ, Stackhouse TL, Spinelli KJ, Boutros SW, Rose EP, Osterberg VR, Luk KC, Raber J, Weissman TA, Unni VK.
    J Biol Chem; 2021 Jan 03; 296():100273. PubMed ID: 33428941
    [Abstract] [Full Text] [Related]

  • 4. Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein.
    Elfarrash S, Jensen NM, Ferreira N, Schmidt SI, Gregersen E, Vestergaard MV, Nabavi S, Meyer M, Jensen PH.
    PLoS One; 2021 Jan 03; 16(10):e0252635. PubMed ID: 34613964
    [Abstract] [Full Text] [Related]

  • 5. Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.
    Rodríguez-Nogales C, Garbayo E, Martínez-Valbuena I, Sebastián V, Luquin MR, Blanco-Prieto MJ.
    Int J Pharm; 2016 Nov 30; 514(1):142-149. PubMed ID: 27863657
    [Abstract] [Full Text] [Related]

  • 6. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.
    Oueslati A, Schneider BL, Aebischer P, Lashuel HA.
    Proc Natl Acad Sci U S A; 2013 Oct 08; 110(41):E3945-54. PubMed ID: 23983262
    [Abstract] [Full Text] [Related]

  • 7. Phosphorylation of synucleins by members of the Polo-like kinase family.
    Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA.
    J Biol Chem; 2010 Jan 22; 285(4):2807-22. PubMed ID: 19889641
    [Abstract] [Full Text] [Related]

  • 8. Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.
    Samuel F, Flavin WP, Iqbal S, Pacelli C, Sri Renganathan SD, Trudeau LE, Campbell EM, Fraser PE, Tandon A.
    J Biol Chem; 2016 Feb 26; 291(9):4374-85. PubMed ID: 26719332
    [Abstract] [Full Text] [Related]

  • 9. Iron-induced oxidative stress contributes to α-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2.
    Wang R, Wang Y, Qu L, Chen B, Jiang H, Song N, Xie J.
    Neurochem Int; 2019 May 26; 125():127-135. PubMed ID: 30797969
    [Abstract] [Full Text] [Related]

  • 10. Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants.
    Salvi M, Trashi E, Marin O, Negro A, Sarno S, Pinna LA.
    Biochem Biophys Res Commun; 2012 Feb 03; 418(1):156-60. PubMed ID: 22248692
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.
    Fitzgerald K, Bergeron M, Willits C, Bowers S, Aubele DL, Goldbach E, Tonn G, Ness D, Olaharski A.
    Toxicol Appl Pharmacol; 2013 May 15; 269(1):1-7. PubMed ID: 23466428
    [Abstract] [Full Text] [Related]

  • 12. Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated α-Synuclein-selective Autophagic Degradation.
    Dahmene M, Bérard M, Oueslati A.
    J Biol Chem; 2017 Mar 03; 292(9):3919-3928. PubMed ID: 28154193
    [Abstract] [Full Text] [Related]

  • 13. PLK2 modulates α-synuclein aggregation in yeast and mammalian cells.
    Basso E, Antas P, Marijanovic Z, Gonçalves S, Tenreiro S, Outeiro TF.
    Mol Neurobiol; 2013 Dec 03; 48(3):854-62. PubMed ID: 23677647
    [Abstract] [Full Text] [Related]

  • 14. Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
    Hong CT, Chen KY, Wang W, Chiu JY, Wu D, Chao TY, Hu CJ, Chau KD, Bamodu OA.
    Cells; 2020 Mar 17; 9(3):. PubMed ID: 32192190
    [Abstract] [Full Text] [Related]

  • 15. Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production.
    Kofoed RH, Zheng J, Ferreira N, Lykke-Andersen S, Salvi M, Betzer C, Reimer L, Jensen TH, Fog K, Jensen PH.
    Neurobiol Dis; 2017 Oct 17; 106():49-62. PubMed ID: 28648742
    [Abstract] [Full Text] [Related]

  • 16. Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains.
    Chen M, Yang W, Li X, Li X, Wang P, Yue F, Yang H, Chan P, Yu S.
    Oncotarget; 2016 Feb 23; 7(8):8466-80. PubMed ID: 27032368
    [Abstract] [Full Text] [Related]

  • 17. Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2.
    Ma D, Shen C, Zhang X, Zhang L, Li L.
    J Integr Neurosci; 2023 Nov 23; 22(6):166. PubMed ID: 38176950
    [Abstract] [Full Text] [Related]

  • 18. Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.
    Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai WP, Chilcote TJ.
    J Biol Chem; 2006 Oct 06; 281(40):29739-52. PubMed ID: 16847063
    [Abstract] [Full Text] [Related]

  • 19. Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.
    Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A.
    J Biol Chem; 2011 Oct 14; 286(41):35863-35873. PubMed ID: 21849493
    [Abstract] [Full Text] [Related]

  • 20. miR-101-3p Contributes to α-Synuclein Aggregation in Neural Cells through the miR-101-3p/SKP1/PLK2 Pathway.
    Zhang M, Liu W, Zhang Q, Hu H.
    J Healthc Eng; 2021 Oct 14; 2021():6147434. PubMed ID: 34234930
    [Abstract] [Full Text] [Related]

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