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Journal Abstract Search

344 related items for PubMed ID: 19012178

  • 1. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease.
    Heptinstall S, Espinosa DI, Manolopoulos P, Glenn JR, White AE, Johnson A, Dovlatova N, Fox SC, May JA, Hermann D, Magnusson O, Stefansson K, Hartman D, Gurney M.
    Platelets; 2008 Dec; 19(8):605-13. PubMed ID: 19012178
    [Abstract] [Full Text] [Related]

  • 2. PGE(2) reverses G(s)-mediated inhibition of platelet aggregation by interaction with EP3 receptors, but adds to non-G(s)-mediated inhibition of platelet aggregation by interaction with EP4 receptors.
    Glenn JR, White AE, Iyu D, Heptinstall S.
    Platelets; 2012 Dec; 23(5):344-51. PubMed ID: 22436052
    [Abstract] [Full Text] [Related]

  • 3. Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
    Singh J, Zeller W, Zhou N, Hategen G, Mishra R, Polozov A, Yu P, Onua E, Zhang J, Zembower D, Kiselyov A, Ramírez JL, Sigthorsson G, Bjornsson JM, Thorsteinsdottir M, Andrésson T, Bjarnadottir M, Magnusson O, Fabre JE, Stefansson K, Gurney ME.
    ACS Chem Biol; 2009 Feb 20; 4(2):115-26. PubMed ID: 19193156
    [Abstract] [Full Text] [Related]

  • 4. P2Y₁₂ and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP.
    Iyú D, Glenn JR, White AE, Fox SC, Dovlatova N, Heptinstall S.
    Platelets; 2011 Feb 20; 22(7):504-15. PubMed ID: 21591981
    [Abstract] [Full Text] [Related]

  • 5. Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors.
    Petrucci G, De Cristofaro R, Rutella S, Ranelletti FO, Pocaterra D, Lancellotti S, Habib A, Patrono C, Rocca B.
    J Pharmacol Exp Ther; 2011 Feb 20; 336(2):391-402. PubMed ID: 21059804
    [Abstract] [Full Text] [Related]

  • 6. Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor.
    Dovlatova N, Wijeyeratne YD, Fox SC, Manolopoulos P, Johnson AJ, White AE, Latif ML, Ralevic V, Heptinstall S.
    Thromb Haemost; 2008 Aug 20; 100(2):261-70. PubMed ID: 18690346
    [Abstract] [Full Text] [Related]

  • 7. PGE1 and PGE2 modify platelet function through different prostanoid receptors.
    Iyú D, Jüttner M, Glenn JR, White AE, Johnson AJ, Fox SC, Heptinstall S.
    Prostaglandins Other Lipid Mediat; 2011 Feb 20; 94(1-2):9-16. PubMed ID: 21095237
    [Abstract] [Full Text] [Related]

  • 8. Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques.
    Penz SM, Reininger AJ, Toth O, Deckmyn H, Brandl R, Siess W.
    Thromb Haemost; 2007 Mar 20; 97(3):435-43. PubMed ID: 17334511
    [Abstract] [Full Text] [Related]

  • 9. Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.
    Singh J, Zeller W, Zhou N, Hategan G, Mishra RK, Polozov A, Yu P, Onua E, Zhang J, Ramírez JL, Sigthorsson G, Thorsteinnsdottir M, Kiselyov AS, Zembower DE, Andrésson T, Gurney ME.
    J Med Chem; 2010 Jan 14; 53(1):18-36. PubMed ID: 19957930
    [Abstract] [Full Text] [Related]

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  • 13. Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence.
    Tilly P, Charles AL, Ludwig S, Slimani F, Gross S, Meilhac O, Geny B, Stefansson K, Gurney ME, Fabre JE.
    Cardiovasc Res; 2014 Mar 01; 101(3):482-91. PubMed ID: 24323317
    [Abstract] [Full Text] [Related]

  • 14. The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function.
    Iyú D, Glenn JR, White AE, Johnson AJ, Fox SC, Heptinstall S.
    Platelets; 2010 Mar 01; 21(5):329-42. PubMed ID: 20433310
    [Abstract] [Full Text] [Related]

  • 15. Mode of action of P2Y(12 ) antagonists as inhibitors of platelet function.
    Iyú D, Glenn JR, White AE, Fox SC, van Giezen H, Nylander S, Heptinstall S.
    Thromb Haemost; 2011 Jan 01; 105(1):96-106. PubMed ID: 20941457
    [Abstract] [Full Text] [Related]

  • 16. The active metabolite of prasugrel effectively blocks the platelet P2Y12 receptor and inhibits procoagulant and pro-inflammatory platelet responses.
    Judge HM, Buckland RJ, Sugidachi A, Jakubowski JA, Storey RF.
    Platelets; 2008 Mar 01; 19(2):125-33. PubMed ID: 18297550
    [Abstract] [Full Text] [Related]

  • 17. Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood.
    Storey RF, Newby LJ, Heptinstall S.
    Platelets; 2001 Nov 01; 12(7):443-7. PubMed ID: 11674863
    [Abstract] [Full Text] [Related]

  • 18. Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin.
    Storey RF, May JA, Heptinstall S.
    Thromb Res; 2005 Nov 01; 115(4):301-7. PubMed ID: 15668190
    [Abstract] [Full Text] [Related]

  • 19. Augmentation of U46619 induced human platelet aggregation by aspirin.
    Kim JM, Koo YK, Jin J, Lee YY, Park S, Yun-Choi HS.
    Platelets; 2009 Mar 01; 20(2):111-9. PubMed ID: 19235053
    [Abstract] [Full Text] [Related]

  • 20. Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.
    Béres BJ, Tóth-Zsámboki E, Vargová K, László A, Masszi T, Kerecsen G, Préda I, Kiss RG.
    Thromb Haemost; 2008 Nov 01; 100(5):829-38. PubMed ID: 18989527
    [Abstract] [Full Text] [Related]

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