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Journal Abstract Search

263 related items for PubMed ID: 19047481

  • 1. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
    Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ.
    Mol Pharmacol; 2009 Mar; 75(3):577-88. PubMed ID: 19047481
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  • 2. Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor.
    Khajehali E, Valant C, Jörg M, Tobin AB, Conn PJ, Lindsley CW, Sexton PM, Scammells PJ, Christopoulos A.
    Biochem Pharmacol; 2018 Aug; 154():243-254. PubMed ID: 29777683
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  • 4. Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist.
    Watt ML, Schober DA, Hitchcock S, Liu B, Chesterfield AK, McKinzie D, Felder CC.
    J Pharmacol Exp Ther; 2011 Aug; 338(2):622-32. PubMed ID: 21558436
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  • 5. Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands.
    Davis CN, Bradley SR, Schiffer HH, Friberg M, Koch K, Tolf BR, Bonhaus DW, Lameh J.
    BMC Pharmacol; 2009 Dec 02; 9():14. PubMed ID: 19951444
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  • 11. Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
    Smith DL, Davoren JE, Edgerton JR, Lazzaro JT, Lee CW, Neal S, Zhang L, Grimwood S.
    Mol Pharmacol; 2016 Sep 02; 90(3):177-87. PubMed ID: 27382013
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  • 12. Potentiation of Muscarinic M3 Receptor Activation through a New Allosteric Site with a Novel Positive Allosteric Modulator ASP8302.
    Okimoto R, Ino K, Ishizu K, Takamatsu H, Sakamoto K, Yuyama H, Fuji H, Someya A, Ohtake A, Ishigami T, Masuda N, Takeda M, Kajioka S, Yoshimura N.
    J Pharmacol Exp Ther; 2021 Oct 02; 379(1):64-73. PubMed ID: 34244231
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  • 14. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
    Digby GJ, Noetzel MJ, Bubser M, Utley TJ, Walker AG, Byun NE, Lebois EP, Xiang Z, Sheffler DJ, Cho HP, Davis AA, Nemirovsky NE, Mennenga SE, Camp BW, Bimonte-Nelson HA, Bode J, Italiano K, Morrison R, Daniels JS, Niswender CM, Olive MF, Lindsley CW, Jones CK, Conn PJ.
    J Neurosci; 2012 Jun 20; 32(25):8532-44. PubMed ID: 22723693
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  • 15. The pharmacologic characterization of allosteric molecules: Gq protein activation.
    Bdioui S, Verdi J, Pierre N, Trinquet E, Roux T, Kenakin T.
    J Recept Signal Transduct Res; 2019 Apr 20; 39(2):106-113. PubMed ID: 31322035
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  • 16. Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.
    Leach K, Loiacono RE, Felder CC, McKinzie DL, Mogg A, Shaw DB, Sexton PM, Christopoulos A.
    Neuropsychopharmacology; 2010 Mar 20; 35(4):855-69. PubMed ID: 19940843
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  • 17. Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles.
    Dallagnol JCC, Khajehali E, van der Westhuizen ET, Jörg M, Valant C, Gonçalves AG, Capuano B, Christopoulos A, Scammells PJ.
    J Med Chem; 2018 Apr 12; 61(7):2875-2894. PubMed ID: 29544056
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  • 18. Contrasting effects of allosteric and orthosteric agonists on m1 muscarinic acetylcholine receptor internalization and down-regulation.
    Thomas RL, Langmead CJ, Wood MD, Challiss RA.
    J Pharmacol Exp Ther; 2009 Dec 12; 331(3):1086-95. PubMed ID: 19767446
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  • 19. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.
    Jacobson MA, Kreatsoulas C, Pascarella DM, O'Brien JA, Sur C.
    Mol Pharmacol; 2010 Oct 12; 78(4):648-57. PubMed ID: 20660086
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  • 20. Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
    Jakubík J, Randáková A, El-Fakahany EE, Dolezal V.
    BMC Pharmacol; 2009 Dec 28; 9():15. PubMed ID: 20038295
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