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Journal Abstract Search

123 related items for PubMed ID: 19054673

  • 1. 5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ruebsam F, Tran CV, Li LS, Kim SH, Xiang AX, Zhou Y, Blazel JK, Sun Z, Dragovich PS, Zhao J, McGuire HM, Murphy DE, Tran MT, Stankovic N, Ellis DA, Gobbi A, Showalter RE, Webber SE, Shah AM, Tsan M, Patel RA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.
    Bioorg Med Chem Lett; 2009 Jan 15; 19(2):451-8. PubMed ID: 19054673
    [Abstract] [Full Text] [Related]

  • 2. 5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ellis DA, Blazel JK, Tran CV, Ruebsam F, Murphy DE, Li LS, Zhao J, Zhou Y, McGuire HM, Xiang AX, Webber SE, Zhao Q, Han Q, Kissinger CR, Lardy M, Gobbi A, Showalter RE, Shah AM, Tsan M, Patel RA, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L.
    Bioorg Med Chem Lett; 2009 Nov 01; 19(21):6047-52. PubMed ID: 19796938
    [Abstract] [Full Text] [Related]

  • 3. Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
    Ruebsam F, Murphy DE, Tran CV, Li LS, Zhao J, Dragovich PS, McGuire HM, Xiang AX, Sun Z, Ayida BK, Blazel JK, Kim SH, Zhou Y, Han Q, Kissinger CR, Webber SE, Showalter RE, Shah AM, Tsan M, Patel RA, Thompson PA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Khandurina J, Brooks J, Okamoto E, Kirkovsky L.
    Bioorg Med Chem Lett; 2009 Nov 15; 19(22):6404-12. PubMed ID: 19818610
    [Abstract] [Full Text] [Related]

  • 4. Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ruebsam F, Sun Z, Ayida BK, Webber SE, Zhou Y, Zhao Q, Kissinger CR, Showalter RE, Shah AM, Tsan M, Patel R, Lebrun LA, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.
    Bioorg Med Chem Lett; 2008 Sep 15; 18(18):5002-5. PubMed ID: 18722768
    [Abstract] [Full Text] [Related]

  • 5. Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ruebsam F, Webber SE, Tran MT, Tran CV, Murphy DE, Zhao J, Dragovich PS, Kim SH, Li LS, Zhou Y, Han Q, Kissinger CR, Showalter RE, Lardy M, Shah AM, Tsan M, Patel R, Lebrun LA, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3616-21. PubMed ID: 18487044
    [Abstract] [Full Text] [Related]

  • 6.
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  • 7. Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
    Gopalsamy A, Aplasca A, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):457-60. PubMed ID: 16274990
    [Abstract] [Full Text] [Related]

  • 8. Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
    Kim SH, Tran MT, Ruebsam F, Xiang AX, Ayida B, McGuire H, Ellis D, Blazel J, Tran CV, Murphy DE, Webber SE, Zhou Y, Shah AM, Tsan M, Showalter RE, Patel R, Gobbi A, LeBrun LA, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L, Zhao Q, Han Q, Kissinger CR.
    Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4181-5. PubMed ID: 18554907
    [Abstract] [Full Text] [Related]

  • 9. Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.
    Chen CM, He Y, Lu L, Lim HB, Tripathi RL, Middleton T, Hernandez LE, Beno DW, Long MA, Kati WM, Bosse TD, Larson DP, Wagner R, Lanford RE, Kohlbrenner WE, Kempf DJ, Pilot-Matias TJ, Molla A.
    Antimicrob Agents Chemother; 2007 Dec 15; 51(12):4290-6. PubMed ID: 17908950
    [Abstract] [Full Text] [Related]

  • 10.
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  • 11. 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
    Ellis DA, Blazel JK, Webber SE, Tran CV, Dragovich PS, Sun Z, Ruebsam F, McGuire HM, Xiang AX, Zhao J, Li LS, Zhou Y, Han Q, Kissinger CR, Showalter RE, Lardy M, Shah AM, Tsan M, Patel R, LeBrun LA, Kamran R, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4628-32. PubMed ID: 18662878
    [Abstract] [Full Text] [Related]

  • 12. Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.
    Ishida T, Suzuki T, Hirashima S, Mizutani K, Yoshida A, Ando I, Ikeda S, Adachi T, Hashimoto H.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1859-63. PubMed ID: 16455252
    [Abstract] [Full Text] [Related]

  • 13. Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors.
    Yan S, Appleby T, Larson G, Wu JZ, Hamatake R, Hong Z, Yao N.
    Bioorg Med Chem Lett; 2006 Nov 15; 16(22):5888-91. PubMed ID: 16934455
    [Abstract] [Full Text] [Related]

  • 14. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
    Hendricks RT, Fell JB, Blake JF, Fischer JP, Robinson JE, Spencer SR, Stengel PJ, Bernacki AL, Leveque VJ, Le Pogam S, Rajyaguru S, Najera I, Josey JA, Harris JR, Swallow S.
    Bioorg Med Chem Lett; 2009 Jul 01; 19(13):3637-41. PubMed ID: 19447623
    [Abstract] [Full Text] [Related]

  • 15. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
    Sergeeva MV, Zhou Y, Bartkowski DM, Nolan TG, Norris DA, Okamoto E, Kirkovsky L, Kamran R, Lebrun LA, Tsan M, Patel R, Shah AM, Lardy M, Gobbi A, Li LS, Zhao J, Bertolini T, Stankovic N, Sun Z, Murphy DE, Webber SE, Dragovich PS.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3421-6. PubMed ID: 18442904
    [Abstract] [Full Text] [Related]

  • 16. Discovery of an irreversible HCV NS5B polymerase inhibitor.
    Zeng Q, Nair AG, Rosenblum SB, Huang HC, Lesburg CA, Jiang Y, Selyutin O, Chan TY, Bennett F, Chen KX, Venkatraman S, Sannigrahi M, Velazquez F, Duca JS, Gavalas S, Huang Y, Pu H, Wang L, Pinto P, Vibulbhan B, Agrawal S, Ferrari E, Jiang CK, Li C, Hesk D, Gesell J, Sorota S, Shih NY, Njoroge FG, Kozlowski JA.
    Bioorg Med Chem Lett; 2013 Dec 15; 23(24):6585-7. PubMed ID: 24252545
    [Abstract] [Full Text] [Related]

  • 17. 2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid with inbuilt β-N-hydroxy-γ-keto-acid pharmacophore as HCV NS5B polymerase inhibitors.
    Deore RR, Chen GS, Chen CS, Chang PT, Chuang MH, Chern TR, Wang HC, Chern JW.
    Curr Med Chem; 2012 Dec 15; 19(4):613-24. PubMed ID: 22204334
    [Abstract] [Full Text] [Related]

  • 18. Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.
    Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S, Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY, Orlowski M, Feld B, O'Connell J.
    J Med Chem; 2004 Dec 16; 47(26):6603-8. PubMed ID: 15588095
    [Abstract] [Full Text] [Related]

  • 19. Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.
    Wagner R, Larson DP, Beno DW, Bosse TD, Darbyshire JF, Gao Y, Gates BD, He W, Henry RF, Hernandez LE, Hutchinson DK, Jiang WW, Kati WM, Klein LL, Koev G, Kohlbrenner W, Krueger AC, Liu J, Liu Y, Long MA, Maring CJ, Masse SV, Middleton T, Montgomery DA, Pratt JK, Stuart P, Molla A, Kempf DJ.
    J Med Chem; 2009 Mar 26; 52(6):1659-69. PubMed ID: 19226162
    [Abstract] [Full Text] [Related]

  • 20. Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
    Gopalsamy A, Lim K, Ellingboe JW, Krishnamurthy G, Orlowski M, Feld B, van Zeijl M, Howe AY.
    Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4221-4. PubMed ID: 15261274
    [Abstract] [Full Text] [Related]

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