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301 related items for PubMed ID: 19064628

  • 1. 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
    Su W, Yeku O, Olepu S, Genna A, Park JS, Ren H, Du G, Gelb MH, Morris AJ, Frohman MA.
    Mol Pharmacol; 2009 Mar; 75(3):437-46. PubMed ID: 19064628
    [Abstract] [Full Text] [Related]

  • 2. Two sites of action for PLD2 inhibitors: The enzyme catalytic center and an allosteric, phosphoinositide biding pocket.
    Ganesan R, Mahankali M, Alter G, Gomez-Cambronero J.
    Biochim Biophys Acta; 2015 Mar; 1851(3):261-72. PubMed ID: 25532944
    [Abstract] [Full Text] [Related]

  • 3. The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells.
    Stricker HM, Rommerswinkel N, Keil S, Gnoth SA, Niggemann B, Dittmar T.
    Cell Commun Signal; 2021 Apr 08; 19(1):43. PubMed ID: 33832505
    [Abstract] [Full Text] [Related]

  • 4. Novel lipid-soluble thiol-redox antioxidant and heavy metal chelator, N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) and phospholipase D-specific inhibitor, 5-fluoro-2-indolyl des-chlorohalopemide (FIPI) attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.
    Secor JD, Kotha SR, Gurney TO, Patel RB, Kefauver NR, Gupta N, Morris AJ, Haley BE, Parinandi NL.
    Int J Toxicol; 2011 Dec 08; 30(6):619-38. PubMed ID: 21994240
    [Abstract] [Full Text] [Related]

  • 5. A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity.
    Elvers M, Grenegård M, Khoshjabinzadeh H, Münzer P, Borst O, Tian H, Di Paolo G, Lang F, Gawaz M, Lindahl TL, Fälker K.
    Cell Signal; 2012 Sep 08; 24(9):1743-52. PubMed ID: 22579635
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report.
    Stegner D, Thielmann I, Kraft P, Frohman MA, Stoll G, Nieswandt B.
    Arterioscler Thromb Vasc Biol; 2013 Sep 08; 33(9):2212-7. PubMed ID: 23868933
    [Abstract] [Full Text] [Related]

  • 7. Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase D and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells.
    Patel RB, Kotha SR, Sherwani SI, Sliman SM, Gurney TO, Loar B, Butler SO, Morris AJ, Marsh CB, Parinandi NL.
    Int J Toxicol; 2011 Feb 08; 30(1):69-90. PubMed ID: 21131602
    [Abstract] [Full Text] [Related]

  • 8. Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.
    Yanase Y, Carvou N, Frohman MA, Cockcroft S.
    Biochem J; 2009 Dec 14; 425(1):179-93. PubMed ID: 19845506
    [Abstract] [Full Text] [Related]

  • 9. Structural Insights for Drugs Developed for Phospholipase D Enzymes.
    Stieglitz KA.
    Curr Drug Discov Technol; 2018 Dec 14; 15(2):81-93. PubMed ID: 28814238
    [Abstract] [Full Text] [Related]

  • 10. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.
    Olala LO, Seremwe M, Tsai YY, Bollag WB.
    Mol Cell Endocrinol; 2013 Feb 05; 366(1):31-7. PubMed ID: 23178798
    [Abstract] [Full Text] [Related]

  • 11. Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion.
    Ye Q, Kantonen S, Gomez-Cambronero J.
    J Mol Biol; 2013 Feb 22; 425(4):755-66. PubMed ID: 23238254
    [Abstract] [Full Text] [Related]

  • 12. Determination of the formation rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two selective PLD inhibitors.
    Schröck A, Henzi A, Bütikofer P, König S, Weinmann W.
    Alcohol; 2018 Dec 22; 73():1-7. PubMed ID: 30103144
    [Abstract] [Full Text] [Related]

  • 13. PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.
    Henkels KM, Muppani NR, Gomez-Cambronero J.
    PLoS One; 2016 Dec 22; 11(11):e0166553. PubMed ID: 27851813
    [Abstract] [Full Text] [Related]

  • 14. Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils.
    Chang LC, Huang TH, Chang CS, Tsai YR, Lin RH, Lee PW, Hsu MF, Huang LJ, Wang JP.
    Biochem Pharmacol; 2011 Jan 15; 81(2):269-78. PubMed ID: 20965153
    [Abstract] [Full Text] [Related]

  • 15. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.
    Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW.
    Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1916-20. PubMed ID: 19268584
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of phospholipases influences the metabolism of wound-induced benzylisoquinoline alkaloids in Papaver somniferum L.
    Jablonická V, Ziegler J, Vatehová Z, Lišková D, Heilmann I, Obložinský M, Heilmann M.
    J Plant Physiol; 2018 Apr 01; 223():1-8. PubMed ID: 29433083
    [Abstract] [Full Text] [Related]

  • 17. Neutrophil transepithelial migration in response to the chemoattractant fMLP but not C5a is phospholipase D-dependent and related to the use of CD11b/CD18.
    Carrigan SO, Pink DB, Stadnyk AW.
    J Leukoc Biol; 2007 Dec 01; 82(6):1575-84. PubMed ID: 17724165
    [Abstract] [Full Text] [Related]

  • 18. Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph model.
    Henkels KM, Boivin GP, Dudley ES, Berberich SJ, Gomez-Cambronero J.
    Oncogene; 2013 Dec 05; 32(49):5551-62. PubMed ID: 23752189
    [Abstract] [Full Text] [Related]

  • 19. Targeting Phospholipase D Genetically and Pharmacologically for Studying Leukocyte Function.
    Gomez-Cambronero J, Ganesan R.
    Methods Mol Biol; 2018 Dec 05; 1835():297-314. PubMed ID: 30109659
    [Abstract] [Full Text] [Related]

  • 20. Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.
    Frondorf K, Henkels KM, Frohman MA, Gomez-Cambronero J.
    J Biol Chem; 2010 May 21; 285(21):15837-47. PubMed ID: 20304930
    [Abstract] [Full Text] [Related]

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