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145 related items for PubMed ID: 19066338

  • 1. Microtubule binding and disruption and induction of premature senescence by disorazole C(1).
    Tierno MB, Kitchens CA, Petrik B, Graham TH, Wipf P, Xu FL, Saunders WS, Raccor BS, Balachandran R, Day BW, Stout JR, Walczak CE, Ducruet AP, Reese CE, Lazo JS.
    J Pharmacol Exp Ther; 2009 Mar; 328(3):715-22. PubMed ID: 19066338
    [Abstract] [Full Text] [Related]

  • 2. Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.
    Lazo JS, Reese CE, Vogt A, Vollmer LL, Kitchens CA, Günther E, Graham TH, Hopkins CD, Wipf P.
    J Pharmacol Exp Ther; 2010 Mar; 332(3):906-11. PubMed ID: 20008956
    [Abstract] [Full Text] [Related]

  • 3. Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides.
    Hopkins CD, Wipf P.
    Nat Prod Rep; 2009 May; 26(5):585-601. PubMed ID: 19387496
    [Abstract] [Full Text] [Related]

  • 4. Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product.
    Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS.
    Chem Biol Drug Des; 2006 Jan; 67(1):66-73. PubMed ID: 16492150
    [Abstract] [Full Text] [Related]

  • 5. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
    Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E.
    Mol Pharmacol; 1993 Oct; 44(4):757-66. PubMed ID: 8232226
    [Abstract] [Full Text] [Related]

  • 6. Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells.
    Wu S, Guo Z, Hopkins CD, Wei N, Chu E, Wipf P, Schmitz JC.
    Oncotarget; 2015 Dec 01; 6(38):40866-79. PubMed ID: 26506423
    [Abstract] [Full Text] [Related]

  • 7. Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells.
    Elnakady YA, Sasse F, Lünsdorf H, Reichenbach H.
    Biochem Pharmacol; 2004 Mar 01; 67(5):927-35. PubMed ID: 15104246
    [Abstract] [Full Text] [Related]

  • 8. The Disorazole Z Family of Highly Potent Anticancer Natural Products from Sorangium cellulosum: Structure, Bioactivity, Biosynthesis, and Heterologous Expression.
    Gao Y, Birkelbach J, Fu C, Herrmann J, Irschik H, Morgenstern B, Hirschfelder K, Li R, Zhang Y, Jansen R, Müller R.
    Microbiol Spectr; 2023 Aug 17; 11(4):e0073023. PubMed ID: 37318329
    [Abstract] [Full Text] [Related]

  • 9. Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
    Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E.
    Mol Pharmacol; 2003 Jun 17; 63(6):1273-80. PubMed ID: 12761336
    [Abstract] [Full Text] [Related]

  • 10. The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation.
    Carvalho R, Reid R, Viswanathan N, Gramajo H, Julien B.
    Gene; 2005 Oct 10; 359():91-8. PubMed ID: 16084035
    [Abstract] [Full Text] [Related]

  • 11. Theaflavins depolymerize microtubule network through tubulin binding and cause apoptosis of cervical carcinoma HeLa cells.
    Chakrabarty S, Das A, Bhattacharya A, Chakrabarti G.
    J Agric Food Chem; 2011 Mar 09; 59(5):2040-8. PubMed ID: 21323312
    [Abstract] [Full Text] [Related]

  • 12. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
    Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E.
    Biochemistry; 1995 Aug 01; 34(30):9714-21. PubMed ID: 7626642
    [Abstract] [Full Text] [Related]

  • 13. Genistein arrests cell cycle progression of A549 cells at the G(2)/M phase and depolymerizes interphase microtubules through binding to a unique site of tubulin.
    Mukherjee S, Acharya BR, Bhattacharyya B, Chakrabarti G.
    Biochemistry; 2010 Mar 02; 49(8):1702-12. PubMed ID: 20085293
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of mitosis and microtubule function through direct tubulin binding by a novel antiproliferative naphthopyran LY290181.
    Wood DL, Panda D, Wiernicki TR, Wilson L, Jordan MA, Singh JP.
    Mol Pharmacol; 1997 Sep 02; 52(3):437-44. PubMed ID: 9281606
    [Abstract] [Full Text] [Related]

  • 15. Total synthesis of (-)-disorazole C1.
    Wipf P, Graham TH.
    J Am Chem Soc; 2004 Dec 01; 126(47):15346-7. PubMed ID: 15563138
    [Abstract] [Full Text] [Related]

  • 16. Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.
    Gupta K, Bishop J, Peck A, Brown J, Wilson L, Panda D.
    Biochemistry; 2004 Jun 01; 43(21):6645-55. PubMed ID: 15157098
    [Abstract] [Full Text] [Related]

  • 17. A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.
    Tahir SK, Han EK, Credo B, Jae HS, Pietenpol JA, Scatena CD, Wu-Wong JR, Frost D, Sham H, Rosenberg SH, Ng SC.
    Cancer Res; 2001 Jul 15; 61(14):5480-5. PubMed ID: 11454695
    [Abstract] [Full Text] [Related]

  • 18. Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.
    Xu FL, Rbaibi Y, Kiselyov K, Lazo JS, Wipf P, Saunders WS.
    BMC Chem Biol; 2010 Feb 11; 10():1. PubMed ID: 20181182
    [Abstract] [Full Text] [Related]

  • 19. Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine.
    Mohan L, Raghav D, Ashraf SM, Sebastian J, Rathinasamy K.
    Biomed Pharmacother; 2018 Sep 11; 105():506-517. PubMed ID: 29883946
    [Abstract] [Full Text] [Related]

  • 20. Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin.
    Natsume T, Watanabe J, Tamaoki S, Fujio N, Miyasaka K, Kobayashi M.
    Jpn J Cancer Res; 2000 Jul 11; 91(7):737-47. PubMed ID: 10920282
    [Abstract] [Full Text] [Related]

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