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Journal Abstract Search

164 related items for PubMed ID: 19081716

  • 1. Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: elimination of an acid-mediated decomposition pathway.
    Chamberlain SD, Redman AM, Patnaik S, Brickhouse K, Chew YC, Deanda F, Gerding R, Lei H, Moorthy G, Patrick M, Stevens KL, Wilson JW, Brad Shotwell J.
    Bioorg Med Chem Lett; 2009 Jan 15; 19(2):373-7. PubMed ID: 19081716
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  • 2. Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
    Chamberlain SD, Redman AM, Wilson JW, Deanda F, Shotwell JB, Gerding R, Lei H, Yang B, Stevens KL, Hassell AM, Shewchuk LM, Leesnitzer MA, Smith JL, Sabbatini P, Atkins C, Groy A, Rowand JL, Kumar R, Mook RA, Moorthy G, Patnaik S.
    Bioorg Med Chem Lett; 2009 Jan 15; 19(2):360-4. PubMed ID: 19071018
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  • 3. Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
    Chamberlain SD, Wilson JW, Deanda F, Patnaik S, Redman AM, Yang B, Shewchuk L, Sabbatini P, Leesnitzer MA, Groy A, Atkins C, Gerding R, Hassell AM, Lei H, Mook RA, Moorthy G, Rowand JL, Stevens KL, Kumar R, Shotwell JB.
    Bioorg Med Chem Lett; 2009 Jan 15; 19(2):469-73. PubMed ID: 19056263
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  • 4. Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
    Patnaik S, Stevens KL, Gerding R, Deanda F, Shotwell JB, Tang J, Hamajima T, Nakamura H, Leesnitzer MA, Hassell AM, Shewchuck LM, Kumar R, Lei H, Chamberlain SD.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3136-40. PubMed ID: 19394223
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  • 5. Reversible carboxamide-mediated internal activation at C(6) of 2-chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines.
    Chamberlain SD, Gerding RM, Lei H, Moorthy G, Patnaik S, Redman AM, Stevens KL, Wilson JW, Yang B, Shotwell JB.
    J Org Chem; 2008 Dec 05; 73(23):9511-4. PubMed ID: 18998728
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  • 6. Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.
    Stauffer F, Cowan-Jacob SW, Scheufler C, Furet P.
    Bioorg Med Chem Lett; 2016 Apr 15; 26(8):2065-7. PubMed ID: 26951750
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  • 12. Highly selective Janus kinase 3 inhibitors based on a pyrrolo[2,3-d]pyrimidine scaffold: evaluation of WO2013085802.
    Norman P.
    Expert Opin Ther Pat; 2014 Jan 15; 24(1):121-5. PubMed ID: 24147573
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  • 13. Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold.
    Zhao X, Huang W, Wang Y, Xin M, Jin Q, Cai J, Tang F, Zhao Y, Xiang H.
    Bioorg Med Chem; 2015 Feb 15; 23(4):891-901. PubMed ID: 25596757
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  • 15. Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
    Kaspersen SJ, Sørum C, Willassen V, Fuglseth E, Kjøbli E, Bjørkøy G, Sundby E, Hoff BH.
    Eur J Med Chem; 2011 Dec 15; 46(12):6002-14. PubMed ID: 22018877
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  • 17. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
    Wittman MD, Carboni JM, Yang Z, Lee FY, Antman M, Attar R, Balimane P, Chang C, Chen C, Discenza L, Frennesson D, Gottardis MM, Greer A, Hurlburt W, Johnson W, Langley DR, Li A, Li J, Liu P, Mastalerz H, Mathur A, Menard K, Patel K, Sack J, Sang X, Saulnier M, Smith D, Stefanski K, Trainor G, Velaparthi U, Zhang G, Zimmermann K, Vyas DM.
    J Med Chem; 2009 Dec 10; 52(23):7360-3. PubMed ID: 19778024
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  • 18. Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors.
    Musumeci F, Sanna M, Grossi G, Brullo C, Fallacara AL, Schenone S.
    Curr Med Chem; 2017 Dec 10; 24(19):2059-2085. PubMed ID: 28266267
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  • 19. Synthesis and activity of novel 5-substituted pyrrolo[2,3-d]pyrimidine analogues as pp60(c-Src) tyrosine kinase inhibitors.
    Olgen S, Isgör YG, Coban T.
    Arch Pharm (Weinheim); 2008 Feb 10; 341(2):113-20. PubMed ID: 18214841
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  • 20. Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
    Fairhurst RA, Marsilje TH, Stutz S, Boos A, Niklaus M, Chen B, Jiang S, Lu W, Furet P, McCarthy C, Stauffer F, Guagnano V, Vaupel A, Michellys PY, Schnell C, Jeay S.
    Bioorg Med Chem Lett; 2016 Apr 15; 26(8):2057-64. PubMed ID: 26951753
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