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571 related items for PubMed ID: 19119142

  • 1. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
    Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V.
    J Biol Chem; 2009 Feb 27; 284(9):5467-77. PubMed ID: 19119142
    [Abstract] [Full Text] [Related]

  • 2. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells.
    Berdyshev EV, Gorshkova IA, Usatyuk P, Zhao Y, Saatian B, Hubbard W, Natarajan V.
    Cell Signal; 2006 Oct 27; 18(10):1779-92. PubMed ID: 16529909
    [Abstract] [Full Text] [Related]

  • 3. Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
    Diab KJ, Adamowicz JJ, Kamocki K, Rush NI, Garrison J, Gu Y, Schweitzer KS, Skobeleva A, Rajashekhar G, Hubbard WC, Berdyshev EV, Petrache I.
    Am J Respir Crit Care Med; 2010 Feb 15; 181(4):344-52. PubMed ID: 19965812
    [Abstract] [Full Text] [Related]

  • 4. Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.
    Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH.
    J Biol Chem; 2009 Jun 12; 284(24):16090-16098. PubMed ID: 19357080
    [Abstract] [Full Text] [Related]

  • 5. Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.
    Zhao Y, Kalari SK, Usatyuk PV, Gorshkova I, He D, Watkins T, Brindley DN, Sun C, Bittman R, Garcia JG, Berdyshev EV, Natarajan V.
    J Biol Chem; 2007 May 11; 282(19):14165-77. PubMed ID: 17379599
    [Abstract] [Full Text] [Related]

  • 6. Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells.
    Butler J, Lana D, Round O, LaMontagne K.
    Prostaglandins Other Lipid Mediat; 2004 Jan 11; 73(1-2):29-45. PubMed ID: 15165029
    [Abstract] [Full Text] [Related]

  • 7. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.
    Billich A, Bornancin F, Dévay P, Mechtcheriakova D, Urtz N, Baumruker T.
    J Biol Chem; 2003 Nov 28; 278(48):47408-15. PubMed ID: 13129923
    [Abstract] [Full Text] [Related]

  • 8. FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl.
    Wang L, Chiang ET, Simmons JT, Garcia JG, Dudek SM.
    Eur Respir J; 2011 Jul 28; 38(1):78-88. PubMed ID: 21071472
    [Abstract] [Full Text] [Related]

  • 9. Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins.
    Sarai K, Shikata K, Shikata Y, Omori K, Watanabe N, Sasaki M, Nishishita S, Wada J, Goda N, Kataoka N, Makino H.
    Am J Physiol Cell Physiol; 2009 Oct 28; 297(4):C945-54. PubMed ID: 19657053
    [Abstract] [Full Text] [Related]

  • 10. Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor.
    Dudek SM, Camp SM, Chiang ET, Singleton PA, Usatyuk PV, Zhao Y, Natarajan V, Garcia JG.
    Cell Signal; 2007 Aug 28; 19(8):1754-64. PubMed ID: 17475445
    [Abstract] [Full Text] [Related]

  • 11. Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.
    Zemann B, Kinzel B, Müller M, Reuschel R, Mechtcheriakova D, Urtz N, Bornancin F, Baumruker T, Billich A.
    Blood; 2006 Feb 15; 107(4):1454-8. PubMed ID: 16223773
    [Abstract] [Full Text] [Related]

  • 12. FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.
    Vessey DA, Li L, Imhof I, Honbo N, Karliner JS.
    Med Sci Monit Basic Res; 2013 Apr 09; 19():126-32. PubMed ID: 23567658
    [Abstract] [Full Text] [Related]

  • 13. Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.
    Usatyuk PV, He D, Bindokas V, Gorshkova IA, Berdyshev EV, Garcia JG, Natarajan V.
    Am J Physiol Lung Cell Mol Physiol; 2011 Jun 09; 300(6):L840-50. PubMed ID: 21478254
    [Abstract] [Full Text] [Related]

  • 14. Targeting sphingosine-1-phosphate in hematologic malignancies.
    Stevenson CE, Takabe K, Nagahashi M, Milstien S, Spiegel S.
    Anticancer Agents Med Chem; 2011 Nov 09; 11(9):794-8. PubMed ID: 21707492
    [Abstract] [Full Text] [Related]

  • 15. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
    Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissié J, Malavaud B, Waxman J, Cuvillier O.
    Cancer Res; 2010 Nov 01; 70(21):8651-61. PubMed ID: 20959468
    [Abstract] [Full Text] [Related]

  • 16. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
    Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S.
    FEBS Lett; 2003 Nov 06; 554(1-2):189-93. PubMed ID: 14596938
    [Abstract] [Full Text] [Related]

  • 17. Molecular targets of FTY720 (fingolimod).
    Pitman MR, Woodcock JM, Lopez AF, Pitson SM.
    Curr Mol Med; 2012 Dec 06; 12(10):1207-19. PubMed ID: 22834825
    [Abstract] [Full Text] [Related]

  • 18. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.
    Sanchez T, Estrada-Hernandez T, Paik JH, Wu MT, Venkataraman K, Brinkmann V, Claffey K, Hla T.
    J Biol Chem; 2003 Nov 21; 278(47):47281-90. PubMed ID: 12954648
    [Abstract] [Full Text] [Related]

  • 19. Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy.
    Huwiler A, Pfeilschifter J.
    Curr Pharm Des; 2006 Nov 21; 12(35):4625-35. PubMed ID: 17168766
    [Abstract] [Full Text] [Related]

  • 20. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway.
    Li MH, Hla T, Ferrer F.
    Pediatr Blood Cancer; 2013 Sep 21; 60(9):1418-23. PubMed ID: 23704073
    [Abstract] [Full Text] [Related]

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