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373 related items for PubMed ID: 19129465

  • 1. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription.
    Schlöndorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak MR.
    Am J Physiol Cell Physiol; 2009 Mar; 296(3):C558-69. PubMed ID: 19129465
    [Abstract] [Full Text] [Related]

  • 2. Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2).
    Chiluiza D, Krishna S, Schumacher VA, Schlöndorff J.
    J Biol Chem; 2013 Jun 21; 288(25):18407-20. PubMed ID: 23645677
    [Abstract] [Full Text] [Related]

  • 3. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.
    Nijenhuis T, Sloan AJ, Hoenderop JG, Flesche J, van Goor H, Kistler AD, Bakker M, Bindels RJ, de Boer RA, Möller CC, Hamming I, Navis G, Wetzels JF, Berden JH, Reiser J, Faul C, van der Vlag J.
    Am J Pathol; 2011 Oct 21; 179(4):1719-32. PubMed ID: 21839714
    [Abstract] [Full Text] [Related]

  • 4. Activation of NFAT signaling in podocytes causes glomerulosclerosis.
    Wang Y, Jarad G, Tripathi P, Pan M, Cunningham J, Martin DR, Liapis H, Miner JH, Chen F.
    J Am Soc Nephrol; 2010 Oct 21; 21(10):1657-66. PubMed ID: 20651158
    [Abstract] [Full Text] [Related]

  • 5. Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.
    Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, Faul C, Reiser J.
    J Biol Chem; 2013 Dec 20; 288(51):36598-609. PubMed ID: 24194522
    [Abstract] [Full Text] [Related]

  • 6. The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury.
    Verheijden KAT, Sonneveld R, Bakker-van Bebber M, Wetzels JFM, van der Vlag J, Nijenhuis T.
    J Am Soc Nephrol; 2018 Aug 20; 29(8):2099-2109. PubMed ID: 29954830
    [Abstract] [Full Text] [Related]

  • 7. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.
    Koitabashi N, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli GF, Kass DA.
    J Mol Cell Cardiol; 2010 Apr 20; 48(4):713-24. PubMed ID: 19961855
    [Abstract] [Full Text] [Related]

  • 8. Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway.
    Xia S, Liu Y, Li X, Thilo F, Tepel M.
    Cell Physiol Biochem; 2016 Apr 20; 38(2):659-69. PubMed ID: 26849622
    [Abstract] [Full Text] [Related]

  • 9. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity.
    Carrasquillo R, Tian D, Krishna S, Pollak MR, Greka A, Schlöndorff J.
    BMC Cell Biol; 2012 Nov 21; 13():33. PubMed ID: 23171048
    [Abstract] [Full Text] [Related]

  • 10. Participation of the AngII/TRPC6/NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes.
    Ma R, Xu Y, Zhou H, Zhang D, Yao D, Song L, Liu Y.
    Mol Med Rep; 2019 Mar 21; 19(3):2421-2430. PubMed ID: 30664212
    [Abstract] [Full Text] [Related]

  • 11. Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis.
    Kanda S, Harita Y, Shibagaki Y, Sekine T, Igarashi T, Inoue T, Hattori S.
    Mol Biol Cell; 2011 Jun 01; 22(11):1824-35. PubMed ID: 21471003
    [Abstract] [Full Text] [Related]

  • 12. Gq signaling causes glomerular injury by activating TRPC6.
    Wang L, Jirka G, Rosenberg PB, Buckley AF, Gomez JA, Fields TA, Winn MP, Spurney RF.
    J Clin Invest; 2015 May 01; 125(5):1913-26. PubMed ID: 25844902
    [Abstract] [Full Text] [Related]

  • 13. Pleiotropic signaling evoked by tumor necrosis factor in podocytes.
    Abkhezr M, Kim EY, Roshanravan H, Nikolos F, Thomas C, Hagmann H, Benzing T, Dryer SE.
    Am J Physiol Renal Physiol; 2015 Jul 15; 309(2):F98-108. PubMed ID: 26017975
    [Abstract] [Full Text] [Related]

  • 14. Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease.
    Krall P, Canales CP, Kairath P, Carmona-Mora P, Molina J, Carpio JD, Ruiz P, Mezzano SA, Li J, Wei C, Reiser J, Young JI, Walz K.
    PLoS One; 2010 Sep 20; 5(9):e12859. PubMed ID: 20877463
    [Abstract] [Full Text] [Related]

  • 15. Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli.
    Ilatovskaya DV, Palygin O, Chubinskiy-Nadezhdin V, Negulyaev YA, Ma R, Birnbaumer L, Staruschenko A.
    Kidney Int; 2014 Sep 20; 86(3):506-14. PubMed ID: 24646854
    [Abstract] [Full Text] [Related]

  • 16. Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species.
    Kim EY, Anderson M, Dryer SE.
    Am J Physiol Renal Physiol; 2012 Feb 01; 302(3):F298-307. PubMed ID: 22031853
    [Abstract] [Full Text] [Related]

  • 17. Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.
    Szabó T, Ambrus L, Zákány N, Balla G, Bíró T.
    Acta Physiol Hung; 2015 Sep 01; 102(3):241-51. PubMed ID: 26551740
    [Abstract] [Full Text] [Related]

  • 18. TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.
    Ilatovskaya DV, Staruschenko A.
    Am J Physiol Renal Physiol; 2015 Sep 01; 309(5):F393-7. PubMed ID: 26084930
    [Abstract] [Full Text] [Related]

  • 19. Identification and functional analysis of a novel TRPC6 mutation associated with late onset familial focal segmental glomerulosclerosis in Chinese patients.
    Zhu B, Chen N, Wang ZH, Pan XX, Ren H, Zhang W, Wang WM.
    Mutat Res; 2009 May 12; 664(1-2):84-90. PubMed ID: 19124028
    [Abstract] [Full Text] [Related]

  • 20. Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.
    Talbot BE, Vandorpe DH, Stotter BR, Alper SL, Schlondorff JS.
    J Biol Chem; 2019 Aug 23; 294(34):12655-12669. PubMed ID: 31266804
    [Abstract] [Full Text] [Related]

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