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Journal Abstract Search

442 related items for PubMed ID: 19146377

  • 1. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
    Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA.
    Chem Res Toxicol; 2009 Feb; 22(2):357-68. PubMed ID: 19146377
    [Abstract] [Full Text] [Related]

  • 2. Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
    Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS.
    Drug Metab Dispos; 2010 Oct; 38(10):1900-5. PubMed ID: 20595376
    [Abstract] [Full Text] [Related]

  • 3. Predicting circulating human metabolites: how good are we?
    Anderson S, Luffer-Atlas D, Knadler MP.
    Chem Res Toxicol; 2009 Feb; 22(2):243-56. PubMed ID: 19138063
    [Abstract] [Full Text] [Related]

  • 4. From known knowns to known unknowns: predicting in vivo drug metabolites.
    Pelkonen O, Tolonen A, Korjamo T, Turpeinen M, Raunio H.
    Bioanalysis; 2009 May; 1(2):393-414. PubMed ID: 21083174
    [Abstract] [Full Text] [Related]

  • 5. In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
    Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB.
    J Pharmacol Exp Ther; 2012 Oct; 343(1):134-44. PubMed ID: 22776955
    [Abstract] [Full Text] [Related]

  • 6. Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
    Gómez-Lechón MJ, Castell JV, Donato MT.
    Chem Biol Interact; 2007 May 20; 168(1):30-50. PubMed ID: 17134688
    [Abstract] [Full Text] [Related]

  • 7. Role of human liver microsomes in in vitro metabolism of drugs-a review.
    Asha S, Vidyavathi M.
    Appl Biochem Biotechnol; 2010 Mar 20; 160(6):1699-722. PubMed ID: 19582595
    [Abstract] [Full Text] [Related]

  • 8. Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies.
    Tiller PR, Yu S, Bateman KP, Castro-Perez J, McIntosh IS, Kuo Y, Baillie TA.
    Rapid Commun Mass Spectrom; 2008 Nov 20; 22(22):3510-6. PubMed ID: 18853407
    [Abstract] [Full Text] [Related]

  • 9. Human hepatocytes: isolation, cryopreservation and applications in drug development.
    Li AP.
    Chem Biol Interact; 2007 May 20; 168(1):16-29. PubMed ID: 17270162
    [Abstract] [Full Text] [Related]

  • 10. An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant.
    Andersson TB, Sjöberg H, Hoffmann KJ, Boobis AR, Watts P, Edwards RJ, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Goldfarb PS, Lewis DF, Corcos L, Guillouzo A, Taavitsainen P, Pelkonen O.
    Drug Metab Dispos; 2001 May 20; 29(5):712-20. PubMed ID: 11302938
    [Abstract] [Full Text] [Related]

  • 11. Approaches to the assessment of stable and chemically reactive drug metabolites in early clinical trials.
    Baillie TA.
    Chem Res Toxicol; 2009 Feb 20; 22(2):263-6. PubMed ID: 19216579
    [Abstract] [Full Text] [Related]

  • 12. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.
    Miners JO, Knights KM, Houston JB, Mackenzie PI.
    Biochem Pharmacol; 2006 May 28; 71(11):1531-9. PubMed ID: 16455060
    [Abstract] [Full Text] [Related]

  • 13. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
    Lang D, Freudenberger C, Weinz C.
    Drug Metab Dispos; 2009 May 28; 37(5):1046-55. PubMed ID: 19196846
    [Abstract] [Full Text] [Related]

  • 14. Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability.
    Cai H, Stoner C, Reddy A, Freiwald S, Smith D, Winters R, Stankovic C, Surendran N.
    Int J Pharm; 2006 Feb 03; 308(1-2):133-9. PubMed ID: 16352407
    [Abstract] [Full Text] [Related]

  • 15. Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures.
    Hewitt NJ, Bühring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D.
    Drug Metab Dispos; 2001 Jul 03; 29(7):1042-50. PubMed ID: 11408372
    [Abstract] [Full Text] [Related]

  • 16. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N, Makino C, Murayama N.
    Chem Res Toxicol; 2007 Mar 03; 20(3):455-64. PubMed ID: 17309281
    [Abstract] [Full Text] [Related]

  • 17. The pivotal role of hepatocytes in drug discovery.
    Soars MG, McGinnity DF, Grime K, Riley RJ.
    Chem Biol Interact; 2007 May 20; 168(1):2-15. PubMed ID: 17208208
    [Abstract] [Full Text] [Related]

  • 18. Strategy for genotoxicity testing--metabolic considerations.
    Ku WW, Bigger A, Brambilla G, Glatt H, Gocke E, Guzzie PJ, Hakura A, Honma M, Martus HJ, Obach RS, Roberts S, Strategy Expert Group, IWGT.
    Mutat Res; 2007 Feb 03; 627(1):59-77. PubMed ID: 17141553
    [Abstract] [Full Text] [Related]

  • 19. [Advances and related issues in the use of in vitro methods to predict metabolic clearance rate of new drugs].
    Zhang Q, Wang GJ.
    Yao Xue Xue Bao; 2007 Oct 03; 42(10):1023-8. PubMed ID: 18229605
    [Abstract] [Full Text] [Related]

  • 20. Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery.
    Mutlib A, Espina R, Vishwanathan K, Babalola K, Chen Z, Dehnhardt C, Venkatesan A, Mansour T, Chaudhary I, Talaat R, Scatina J.
    Drug Metab Dispos; 2011 Jan 03; 39(1):106-16. PubMed ID: 20952552
    [Abstract] [Full Text] [Related]

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