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326 related items for PubMed ID: 19148492

  • 1. Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways.
    Gazitt Y, Kolaparthi V, Moncada K, Thomas C, Freeman J.
    Int J Oncol; 2009 Feb; 34(2):551-61. PubMed ID: 19148492
    [Abstract] [Full Text] [Related]

  • 2. Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.
    Francis LK, Alsayed Y, Leleu X, Jia X, Singha UK, Anderson J, Timm M, Ngo H, Lu G, Huston A, Ehrlich LA, Dimmock E, Lentzsch S, Hideshima T, Roodman GD, Anderson KC, Ghobrial IM.
    Clin Cancer Res; 2006 Nov 15; 12(22):6826-35. PubMed ID: 17121904
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV, Li Y, Rassidakis GZ, Martinez-Valdez H, Medeiros LJ, Younes A.
    Clin Cancer Res; 2006 Jan 15; 12(2):584-90. PubMed ID: 16428504
    [Abstract] [Full Text] [Related]

  • 4. Combination of rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells.
    Roforth MM, Tan C.
    Anticancer Drugs; 2008 Aug 15; 19(7):681-8. PubMed ID: 18594209
    [Abstract] [Full Text] [Related]

  • 5. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
    Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN.
    J Pathol; 2007 Oct 15; 213(2):170-9. PubMed ID: 17768706
    [Abstract] [Full Text] [Related]

  • 6. Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity.
    Tirado OM, Mateo-Lozano S, Notario V.
    Oncogene; 2005 May 05; 24(20):3348-57. PubMed ID: 15782132
    [Abstract] [Full Text] [Related]

  • 7. The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
    Georgakis GV, Li Y, Younes A.
    Br J Haematol; 2006 Oct 05; 135(1):68-71. PubMed ID: 16925576
    [Abstract] [Full Text] [Related]

  • 8. Activation of mTOR signaling pathway contributes to survival of cervical cancer cells.
    Ji J, Zheng PS.
    Gynecol Oncol; 2010 Apr 05; 117(1):103-8. PubMed ID: 20102778
    [Abstract] [Full Text] [Related]

  • 9. Methoxychalcone induces cell-cycle arrest and apoptosis in human hormone-resistant prostate cancer cells through PI 3-kinase-independent inhibition of mTOR pathways.
    Sun YW, Huang WJ, Hsiao CJ, Chen YC, Lu PH, Guh JH.
    Prostate; 2010 Sep 01; 70(12):1295-306. PubMed ID: 20623631
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel.
    Faried LS, Faried A, Kanuma T, Nakazato T, Tamura T, Kuwano H, Minegishi T.
    Eur J Cancer; 2006 May 01; 42(7):934-47. PubMed ID: 16540312
    [Abstract] [Full Text] [Related]

  • 11. Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro.
    Gorshtein A, Rubinfeld H, Kendler E, Theodoropoulou M, Cerovac V, Stalla GK, Cohen ZR, Hadani M, Shimon I.
    Endocr Relat Cancer; 2009 Sep 01; 16(3):1017-27. PubMed ID: 19509067
    [Abstract] [Full Text] [Related]

  • 12. The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level.
    Yu W, Rao Q, Wang M, Tian Z, Lin D, Liu X, Wang J.
    Leuk Res; 2006 May 01; 30(5):575-82. PubMed ID: 16213582
    [Abstract] [Full Text] [Related]

  • 13. 17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis.
    Siegelin MD, Habel A, Gaiser T.
    Neurobiol Dis; 2009 Feb 01; 33(2):243-9. PubMed ID: 19027068
    [Abstract] [Full Text] [Related]

  • 14. Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways.
    Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H.
    Anticancer Res; 2012 Sep 01; 32(9):3643-9. PubMed ID: 22993301
    [Abstract] [Full Text] [Related]

  • 15. Evaluation of the mammalian target of rapamycin pathway and the effect of rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs.
    Gordon IK, Ye F, Kent MS.
    Am J Vet Res; 2008 Aug 01; 69(8):1079-84. PubMed ID: 18672974
    [Abstract] [Full Text] [Related]

  • 16. An expanding role for mTOR in cancer.
    Guertin DA, Sabatini DM.
    Trends Mol Med; 2005 Aug 01; 11(8):353-61. PubMed ID: 16002336
    [Abstract] [Full Text] [Related]

  • 17. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
    Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM.
    Cancer Chemother Pharmacol; 2005 Aug 01; 56(2):126-37. PubMed ID: 15841378
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo.
    Liu X, Choy E, Harmon D, Yang S, Yang C, Mankin H, Hornicek FJ, Duan Z.
    Anticancer Drugs; 2011 Jun 01; 22(5):444-53. PubMed ID: 21399492
    [Abstract] [Full Text] [Related]

  • 19. [Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor].
    Yu WJ, Rao Q, Wang M, Tian Z, Xu ZF, Wang JX.
    Zhonghua Xue Ye Xue Za Zhi; 2007 Oct 01; 28(10):677-80. PubMed ID: 18399173
    [Abstract] [Full Text] [Related]

  • 20. Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines.
    Aissat N, Le Tourneau C, Ghoul A, Serova M, Bieche I, Lokiec F, Raymond E, Faivre S.
    Cancer Chemother Pharmacol; 2008 Jul 01; 62(2):305-13. PubMed ID: 17912526
    [Abstract] [Full Text] [Related]

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