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Journal Abstract Search

371 related items for PubMed ID: 19161460

  • 1. Brain penetration of ivermectin and selamectin in mdr1a,b P-glycoprotein- and bcrp- deficient knockout mice.
    Geyer J, Gavrilova O, Petzinger E.
    J Vet Pharmacol Ther; 2009 Feb; 32(1):87-96. PubMed ID: 19161460
    [Abstract] [Full Text] [Related]

  • 2. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.
    Durmus S, Xu N, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.
    Pharmacol Res; 2013 Oct; 76():9-16. PubMed ID: 23827160
    [Abstract] [Full Text] [Related]

  • 3. The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
    Zhou L, Schmidt K, Nelson FR, Zelesky V, Troutman MD, Feng B.
    Drug Metab Dispos; 2009 May; 37(5):946-55. PubMed ID: 19225039
    [Abstract] [Full Text] [Related]

  • 4. Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
    Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y.
    J Pharmacol Exp Ther; 2010 Jun; 333(3):788-96. PubMed ID: 20304939
    [Abstract] [Full Text] [Related]

  • 5. Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate.
    Kodaira H, Kusuhara H, Fujita T, Ushiki J, Fuse E, Sugiyama Y.
    J Pharmacol Exp Ther; 2011 Dec; 339(3):935-44. PubMed ID: 21934030
    [Abstract] [Full Text] [Related]

  • 6. P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan.
    de Vries NA, Zhao J, Kroon E, Buckle T, Beijnen JH, van Tellingen O.
    Clin Cancer Res; 2007 Nov 01; 13(21):6440-9. PubMed ID: 17975156
    [Abstract] [Full Text] [Related]

  • 7. (R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.
    Römermann K, Wanek T, Bankstahl M, Bankstahl JP, Fedrowitz M, Müller M, Löscher W, Kuntner C, Langer O.
    Nucl Med Biol; 2013 Oct 01; 40(7):873-8. PubMed ID: 23845421
    [Abstract] [Full Text] [Related]

  • 8. Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats.
    Fuchs H, Kishimoto W, Gansser D, Tanswell P, Ishiguro N.
    Drug Metab Dispos; 2014 Oct 01; 42(10):1761-5. PubMed ID: 25053619
    [Abstract] [Full Text] [Related]

  • 9. Impact of P-glycoprotein and breast cancer resistance protein on the brain distribution of antiepileptic drugs in knockout mouse models.
    Nakanishi H, Yonezawa A, Matsubara K, Yano I.
    Eur J Pharmacol; 2013 Jun 15; 710(1-3):20-8. PubMed ID: 23588114
    [Abstract] [Full Text] [Related]

  • 10. Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.
    Choo EF, Ly J, Chan J, Shahidi-Latham SK, Messick K, Plise E, Quiason CM, Yang L.
    Mol Pharm; 2014 Nov 03; 11(11):4199-207. PubMed ID: 25243894
    [Abstract] [Full Text] [Related]

  • 11. Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.
    Sampson KE, Brinker A, Pratt J, Venkatraman N, Xiao Y, Blasberg J, Steiner T, Bourner M, Thompson DC.
    Drug Metab Dispos; 2015 Feb 03; 43(2):199-207. PubMed ID: 25388687
    [Abstract] [Full Text] [Related]

  • 12. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption.
    Uhr M, Steckler T, Yassouridis A, Holsboer F.
    Neuropsychopharmacology; 2000 Apr 03; 22(4):380-7. PubMed ID: 10700657
    [Abstract] [Full Text] [Related]

  • 13. Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
    Vlaming ML, Teunissen SF, van de Steeg E, van Esch A, Wagenaar E, Brunsveld L, de Greef TF, Rosing H, Schellens JH, Beijnen JH, Schinkel AH.
    Mol Pharmacol; 2014 Mar 03; 85(3):520-30. PubMed ID: 24334255
    [Abstract] [Full Text] [Related]

  • 14. An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016).
    Polli JW, Olson KL, Chism JP, John-Williams LS, Yeager RL, Woodard SM, Otto V, Castellino S, Demby VE.
    Drug Metab Dispos; 2009 Feb 03; 37(2):439-42. PubMed ID: 19056914
    [Abstract] [Full Text] [Related]

  • 15. Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.
    Shen J, Carcaboso AM, Hubbard KE, Tagen M, Wynn HG, Panetta JC, Waters CM, Elmeliegy MA, Stewart CF.
    Cancer Res; 2009 Jul 15; 69(14):5885-92. PubMed ID: 19567673
    [Abstract] [Full Text] [Related]

  • 16. Characterization of phosphine complexes of technetium(III) as transport substrates of the multidrug resistance P-glycoprotein and functional markers of P-glycoprotein at the blood-brain barrier.
    Luker GD, Rao VV, Crankshaw CL, Dahlheimer J, Piwnica-Worms D.
    Biochemistry; 1997 Nov 18; 36(46):14218-27. PubMed ID: 9369495
    [Abstract] [Full Text] [Related]

  • 17. P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib.
    Chen Y, Agarwal S, Shaik NM, Chen C, Yang Z, Elmquist WF.
    J Pharmacol Exp Ther; 2009 Sep 18; 330(3):956-63. PubMed ID: 19491323
    [Abstract] [Full Text] [Related]

  • 18. Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
    Enokizono J, Kusuhara H, Ose A, Schinkel AH, Sugiyama Y.
    Drug Metab Dispos; 2008 Jun 18; 36(6):995-1002. PubMed ID: 18322075
    [Abstract] [Full Text] [Related]

  • 19. Roles of P-glycoprotein, Bcrp, and Mrp2 in biliary excretion of spiramycin in mice.
    Tian X, Li J, Zamek-Gliszczynski MJ, Bridges AS, Zhang P, Patel NJ, Raub TJ, Pollack GM, Brouwer KL.
    Antimicrob Agents Chemother; 2007 Sep 18; 51(9):3230-4. PubMed ID: 17576841
    [Abstract] [Full Text] [Related]

  • 20. Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers.
    Brayden DJ, Griffin J.
    Vet Res Commun; 2008 Jan 18; 32(1):93-106. PubMed ID: 17578674
    [Abstract] [Full Text] [Related]

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