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Journal Abstract Search

141 related items for PubMed ID: 19179070

  • 1. Aminofurazans as potent inhibitors of AKT kinase.
    Rouse MB, Seefeld MA, Leber JD, McNulty KC, Sun L, Miller WH, Zhang S, Minthorn EA, Concha NO, Choudhry AE, Schaber MD, Heerding DA.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1508-11. PubMed ID: 19179070
    [Abstract] [Full Text] [Related]

  • 2. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.
    Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R.
    J Med Chem; 2008 Sep 25; 51(18):5663-79. PubMed ID: 18800763
    [Abstract] [Full Text] [Related]

  • 3. Discovery of a novel protein kinase B inhibitor by structure-based virtual screening.
    Medina-Franco JL, Giulianotti MA, Yu Y, Shen L, Yao L, Singh N.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4634-8. PubMed ID: 19604696
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  • 4. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.
    Rhodes N, Heerding DA, Duckett DR, Eberwein DJ, Knick VB, Lansing TJ, McConnell RT, Gilmer TM, Zhang SY, Robell K, Kahana JA, Geske RS, Kleymenova EV, Choudhry AE, Lai Z, Leber JD, Minthorn EA, Strum SL, Wood ER, Huang PS, Copeland RA, Kumar R.
    Cancer Res; 2008 Apr 01; 68(7):2366-74. PubMed ID: 18381444
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  • 5. Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B.
    Collins I, Caldwell J, Fonseca T, Donald A, Bavetsias V, Hunter LJ, Garrett MD, Rowlands MG, Aherne GW, Davies TG, Berdini V, Woodhead SJ, Davis D, Seavers LC, Wyatt PG, Workman P, McDonald E.
    Bioorg Med Chem; 2006 Feb 15; 14(4):1255-73. PubMed ID: 16249095
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  • 6. Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
    Xu R, Banka A, Blake JF, Mitchell IS, Wallace EM, Bencsik JR, Kallan NC, Spencer KL, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2335-40. PubMed ID: 21420856
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  • 7. Discovery of pyrrolopyrimidine inhibitors of Akt.
    Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ.
    Bioorg Med Chem Lett; 2010 Oct 01; 20(19):5607-12. PubMed ID: 20810279
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.
    Zhu GD, Gong J, Gandhi VB, Woods K, Luo Y, Liu X, Guan R, Klinghofer V, Johnson EF, Stoll VS, Mamo M, Li Q, Rosenberg SH, Giranda VL.
    Bioorg Med Chem; 2007 Mar 15; 15(6):2441-52. PubMed ID: 17258463
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
    Li Q, Woods KW, Thomas S, Zhu GD, Packard G, Fisher J, Li T, Gong J, Dinges J, Song X, Abrams J, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V, Des Jong R, Oltersdorf T, Stoll VS, Jakob CG, Rosenberg SH, Giranda VL.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):2000-7. PubMed ID: 16413780
    [Abstract] [Full Text] [Related]

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  • 11. Discovery and SAR of spirochromane Akt inhibitors.
    Kallan NC, Spencer KL, Blake JF, Xu R, Heizer J, Bencsik JR, Mitchell IS, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2410-4. PubMed ID: 21392984
    [Abstract] [Full Text] [Related]

  • 12. Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.
    Hartnett JC, Barnett SF, Bilodeau MT, Defeo-Jones D, Hartman GD, Huber HE, Jones RE, Kral AM, Robinson RG, Wu Z.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2194-7. PubMed ID: 18294842
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  • 16. Docking of protein kinase B inhibitors: implications in the structure-based optimization of a novel scaffold.
    Hernández-Campos A, Velázquez-Martínez I, Castillo R, López-Vallejo F, Jia P, Yu Y, Giulianotti MA, Medina-Franco JL.
    Chem Biol Drug Des; 2010 Sep 01; 76(3):269-76. PubMed ID: 20572809
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  • 18. Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors.
    Seefeld MA, Rouse MB, McNulty KC, Sun L, Wang J, Yamashita DS, Luengo JI, Zhang S, Minthorn EA, Concha NO, Heerding DA.
    Bioorg Med Chem Lett; 2009 Apr 15; 19(8):2244-8. PubMed ID: 19285393
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  • 19. Rapid assembly of diverse and potent allosteric Akt inhibitors.
    Wu Z, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Kohl NE, Hartman GD, Bilodeau MT.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2211-4. PubMed ID: 18296048
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