These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

252 related items for PubMed ID: 19181519

  • 1. Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
    Sun D, Wang Z, Cardozo M, Choi R, Degraffenreid M, Di Y, He X, Jaen JC, Labelle M, Liu J, Ma J, Miao S, Sudom A, Tang L, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1522-7. PubMed ID: 19181519
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors.
    Sun D, Wang Z, Caille S, DeGraffenreid M, Gonzalez-Lopez de Turiso F, Hungate R, Jaen JC, Jiang B, Julian LD, Kelly R, McMinn DL, Kaizerman J, Rew Y, Sudom A, Tu H, Ursu S, Walker N, Willcockson M, Yan X, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):405-10. PubMed ID: 21093258
    [Abstract] [Full Text] [Related]

  • 3. Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.
    Julian LD, Wang Z, Bostick T, Caille S, Choi R, DeGraffenreid M, Di Y, He X, Hungate RW, Jaen JC, Liu J, Monshouwer M, McMinn D, Rew Y, Sudom A, Sun D, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.
    J Med Chem; 2008 Jul 10; 51(13):3953-60. PubMed ID: 18553955
    [Abstract] [Full Text] [Related]

  • 4.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 5.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 6. Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.
    Rew Y, DeGraffenreid M, He X, Jaen JC, McMinn DL, Sun D, Tu H, Ursu S, Powers JP.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3786-90. PubMed ID: 22542009
    [Abstract] [Full Text] [Related]

  • 7. Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.
    Tice CM, Zhao W, Xu Z, Cacatian ST, Simpson RD, Ye YJ, Singh SB, McKeever BM, Lindblom P, Guo J, Krosky PM, Kruk BA, Berbaum J, Harrison RK, Johnson JJ, Bukhtiyarov Y, Panemangalore R, Scott BB, Zhao Y, Bruno JG, Zhuang L, McGeehan GM, He W, Claremon DA.
    Bioorg Med Chem Lett; 2010 Feb 01; 20(3):881-6. PubMed ID: 20064717
    [Abstract] [Full Text] [Related]

  • 8. Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
    Rohde JJ, Pliushchev MA, Sorensen BK, Wodka D, Shuai Q, Wang J, Fung S, Monzon KM, Chiou WJ, Pan L, Deng X, Chovan LE, Ramaiya A, Mullally M, Henry RF, Stolarik DF, Imade HM, Marsh KC, Beno DW, Fey TA, Droz BA, Brune ME, Camp HS, Sham HL, Frevert EU, Jacobson PB, Link JT.
    J Med Chem; 2007 Jan 11; 50(1):149-64. PubMed ID: 17201418
    [Abstract] [Full Text] [Related]

  • 9. 2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
    Jean DJ, Yuan C, Bercot EA, Cupples R, Chen M, Fretland J, Hale C, Hungate RW, Komorowski R, Veniant M, Wang M, Zhang X, Fotsch C.
    J Med Chem; 2007 Feb 08; 50(3):429-32. PubMed ID: 17266194
    [Abstract] [Full Text] [Related]

  • 10. Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
    McMinn DL, Rew Y, Sudom A, Caille S, Degraffenreid M, He X, Hungate R, Jiang B, Jaen J, Julian LD, Kaizerman J, Novak P, Sun D, Tu H, Ursu S, Walker NP, Yan X, Ye Q, Wang Z, Powers JP.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1446-50. PubMed ID: 19185488
    [Abstract] [Full Text] [Related]

  • 11. Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.
    Venier O, Pascal C, Braun A, Namane C, Mougenot P, Crespin O, Pacquet F, Mougenot C, Monseau C, Onofri B, Dadji-Faïhun R, Leger C, Ben-Hassine M, Van-Pham T, Ragot JL, Philippo C, Güssregen S, Engel C, Farjot G, Noah L, Maniani K, Nicolaï E.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2244-51. PubMed ID: 21439819
    [Abstract] [Full Text] [Related]

  • 12. 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
    Johansson L, Fotsch C, Bartberger MD, Castro VM, Chen M, Emery M, Gustafsson S, Hale C, Hickman D, Homan E, Jordan SR, Komorowski R, Li A, McRae K, Moniz G, Matsumoto G, Orihuela C, Palm G, Veniant M, Wang M, Williams M, Zhang J.
    J Med Chem; 2008 May 22; 51(10):2933-43. PubMed ID: 18419108
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
    Ye XY, Yoon D, Chen SY, Nayeem A, Golla R, Seethala R, Wang M, Harper T, Sleczka BG, Apedo A, Li YX, He B, Kirby M, Gordon DA, Robl JA.
    Bioorg Med Chem Lett; 2014 Jan 15; 24(2):654-60. PubMed ID: 24360604
    [Abstract] [Full Text] [Related]

  • 14. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2674-8. PubMed ID: 19395260
    [Abstract] [Full Text] [Related]

  • 15. The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.
    Yan X, Wang Z, Sudom A, Cardozo M, DeGraffenreid M, Di Y, Fan P, He X, Jaen JC, Labelle M, Liu J, Ma J, McMinn D, Miao S, Sun D, Tang L, Tu H, Ursu S, Walker N, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2010 Dec 01; 20(23):7071-5. PubMed ID: 20971000
    [Abstract] [Full Text] [Related]

  • 16. Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
    Yang H, Dou W, Lou J, Leng Y, Shen J.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1340-5. PubMed ID: 18242087
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
    Hofer S, Kratschmar DV, Schernthanner B, Vuorinen A, Schuster D, Odermatt A, Easmon J.
    Bioorg Med Chem Lett; 2013 Oct 01; 23(19):5397-400. PubMed ID: 23981897
    [Abstract] [Full Text] [Related]

  • 18. The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
    Yuan C, St Jean DJ, Liu Q, Cai L, Li A, Han N, Moniz G, Askew B, Hungate RW, Johansson L, Tedenborg L, Pyring D, Williams M, Hale C, Chen M, Cupples R, Zhang J, Jordan S, Bartberger MD, Sun Y, Emery M, Wang M, Fotsch C.
    Bioorg Med Chem Lett; 2007 Nov 15; 17(22):6056-61. PubMed ID: 17919905
    [Abstract] [Full Text] [Related]

  • 19. The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.
    Cheng H, Hoffman J, Le P, Nair SK, Cripps S, Matthews J, Smith C, Yang M, Kupchinsky S, Dress K, Edwards M, Cole B, Walters E, Loh C, Ermolieff J, Fanjul A, Bhat GB, Herrera J, Pauly T, Hosea N, Paderes G, Rejto P.
    Bioorg Med Chem Lett; 2010 May 01; 20(9):2897-902. PubMed ID: 20363126
    [Abstract] [Full Text] [Related]

  • 20. The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors.
    Neelamkavil SF, Boyle CD, Chackalamannil S, Greenlee WJ, Zhang L, Terracina G.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4563-5. PubMed ID: 19625185
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 13.