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167 related items for PubMed ID: 19229248

  • 1. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.
    Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU.
    Cell Death Differ; 2009 Jun; 16(6):869-78. PubMed ID: 19229248
    [Abstract] [Full Text] [Related]

  • 2. GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells.
    Reshi L, Wu HC, Wu JL, Wang HV, Hong JR.
    Apoptosis; 2016 Apr; 21(4):443-58. PubMed ID: 26833308
    [Abstract] [Full Text] [Related]

  • 3. Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.
    Singh PK, Kumar R, Sharma A, Arora R, Jain SK, Sharma RK.
    Biotechnol Appl Biochem; 2009 Jul 09; 54(1):53-64. PubMed ID: 19409072
    [Abstract] [Full Text] [Related]

  • 4. Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.
    Farah IO, Begum RA, Ishaque AB.
    Biomed Sci Instrum; 2007 Jul 09; 43():116-21. PubMed ID: 17487067
    [Abstract] [Full Text] [Related]

  • 5. p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation.
    Sohn D, Essmann F, Schulze-Osthoff K, Jänicke RU.
    Cancer Res; 2006 Dec 01; 66(23):11254-62. PubMed ID: 17145870
    [Abstract] [Full Text] [Related]

  • 6. Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells.
    Sinn B, Schulze J, Schroeder G, Konschak R, Freyer D, Budach V, Tinhofer I.
    Radiat Res; 2010 Nov 01; 174(5):601-10. PubMed ID: 20718603
    [Abstract] [Full Text] [Related]

  • 7. Pifithrin-alpha has a p53-independent cytoprotective effect on docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma HepG2 cells.
    Kanno S, Kurauchi K, Tomizawa A, Yomogida S, Ishikawa M.
    Toxicol Lett; 2015 Jan 22; 232(2):393-402. PubMed ID: 25448278
    [Abstract] [Full Text] [Related]

  • 8. Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition.
    Neitemeier S, Ganjam GK, Diemert S, Culmsee C.
    Apoptosis; 2014 Dec 22; 19(12):1665-77. PubMed ID: 25343947
    [Abstract] [Full Text] [Related]

  • 9. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis.
    Lahiry L, Saha B, Chakraborty J, Bhattacharyya S, Chattopadhyay S, Banerjee S, Choudhuri T, Mandal D, Bhattacharyya A, Sa G, Das T.
    Apoptosis; 2008 Jun 22; 13(6):771-81. PubMed ID: 18454316
    [Abstract] [Full Text] [Related]

  • 10. Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats.
    Liu P, Xu B, Cavalieri TA, Hock CE.
    Shock; 2006 Dec 22; 26(6):608-14. PubMed ID: 17117137
    [Abstract] [Full Text] [Related]

  • 11. Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.
    Wan C, Ma X, Shi S, Zhao J, Nie X, Han J, Xiao J, Wang X, Jiang S, Jiang J.
    Toxicol Appl Pharmacol; 2014 Dec 15; 281(3):294-302. PubMed ID: 25448048
    [Abstract] [Full Text] [Related]

  • 12. P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
    Zeng L, Zhang F, Zhang Z, Xu M, Xu Y, Liu Y, Xu H, Sun X, Sang M, Luo H.
    J Biochem Mol Toxicol; 2021 Aug 15; 35(8):e22822. PubMed ID: 34091999
    [Abstract] [Full Text] [Related]

  • 13. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury.
    Yang LY, Greig NH, Huang YN, Hsieh TH, Tweedie D, Yu QS, Hoffer BJ, Luo Y, Kao YC, Wang JY.
    Neurobiol Dis; 2016 Dec 15; 96():216-226. PubMed ID: 27553877
    [Abstract] [Full Text] [Related]

  • 14. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
    Tyagi A, Singh RP, Agarwal C, Agarwal R.
    Carcinogenesis; 2006 Nov 15; 27(11):2269-80. PubMed ID: 16777994
    [Abstract] [Full Text] [Related]

  • 15. Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
    Liang L, Zhang Z.
    Cell Physiol Biochem; 2016 Nov 15; 38(4):1618-30. PubMed ID: 27119348
    [Abstract] [Full Text] [Related]

  • 16. The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells.
    Abdelalim EM, Tooyama I.
    Biochem Biophys Res Commun; 2012 Apr 13; 420(3):605-10. PubMed ID: 22445757
    [Abstract] [Full Text] [Related]

  • 17. p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
    Xiao P, Hao Y, Zhu X, Wu X.
    Inflammation; 2013 Apr 13; 36(2):272-8. PubMed ID: 22983795
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion.
    Liu P, Xu B, Cavalieri TA, Hock CE.
    Shock; 2008 Nov 13; 30(5):545-51. PubMed ID: 18317410
    [Abstract] [Full Text] [Related]

  • 19. Targeting the p53 pathway to protect the neonatal ischemic brain.
    Nijboer CH, Heijnen CJ, van der Kooij MA, Zijlstra J, van Velthoven CT, Culmsee C, van Bel F, Hagberg H, Kavelaars A.
    Ann Neurol; 2011 Aug 13; 70(2):255-64. PubMed ID: 21674585
    [Abstract] [Full Text] [Related]

  • 20. Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis.
    Bouaziz C, Martel C, Sharaf el dein O, Abid-Essefi S, Brenner C, Lemaire C, Bacha H.
    Toxicol Sci; 2009 Aug 13; 110(2):363-75. PubMed ID: 19541794
    [Abstract] [Full Text] [Related]

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