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185 related items for PubMed ID: 19303774

  • 1. 1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3.
    Christopher JA, Atkinson FL, Bax BD, Brown MJ, Champigny AC, Chuang TT, Jones EJ, Mosley JE, Musgrave JR.
    Bioorg Med Chem Lett; 2009 Apr 15; 19(8):2230-4. PubMed ID: 19303774
    [Abstract] [Full Text] [Related]

  • 2. Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.
    Swahn BM, Huerta F, Kallin E, Malmström J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L.
    Bioorg Med Chem Lett; 2005 Nov 15; 15(22):5095-9. PubMed ID: 16140012
    [Abstract] [Full Text] [Related]

  • 3. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
    Angell RM, Atkinson FL, Brown MJ, Chuang TT, Christopher JA, Cichy-Knight M, Dunn AK, Hightower KE, Malkakorpi S, Musgrave JR, Neu M, Rowland P, Shea RL, Smith JL, Somers DO, Thomas SA, Thompson G, Wang R.
    Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1296-301. PubMed ID: 17194588
    [Abstract] [Full Text] [Related]

  • 4. Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.
    Goettert M, Schattel V, Koch P, Merfort I, Laufer S.
    Chembiochem; 2010 Dec 10; 11(18):2579-88. PubMed ID: 21108268
    [Abstract] [Full Text] [Related]

  • 5. Fluorescence polarization-based competition binding assay for c-Jun N-terminal kinases 1 and 2.
    Ansideri F, Dammann M, Boeckler FM, Koch P.
    Anal Biochem; 2017 Sep 01; 532():26-28. PubMed ID: 28552758
    [Abstract] [Full Text] [Related]

  • 6. Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.
    Cao J, Gao H, Bemis G, Salituro F, Ledeboer M, Harrington E, Wilke S, Taslimi P, Pazhanisamy S, Xie X, Jacobs M, Green J.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2891-5. PubMed ID: 19361991
    [Abstract] [Full Text] [Related]

  • 7. Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase.
    Ansideri F, Lange A, El-Gokha A, Boeckler FM, Koch P.
    Anal Biochem; 2016 Jun 15; 503():28-40. PubMed ID: 26954235
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.
    Jiang R, Frackowiak B, Shin Y, Song X, Chen W, Lin L, Cameron MD, Duckett DR, Kamenecka TM.
    Bioorg Med Chem Lett; 2013 May 01; 23(9):2683-7. PubMed ID: 23518277
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
    Hom RK, Bowers S, Sealy JM, Truong AP, Probst GD, Neitzel ML, Neitz RJ, Fang L, Brogley L, Wu J, Konradi AW, Sham HL, Tóth G, Pan H, Yao N, Artis DR, Quinn K, Sauer JM, Powell K, Ren Z, Bard F, Yednock TA, Griswold-Prenner I.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7303-7. PubMed ID: 21071223
    [Abstract] [Full Text] [Related]

  • 10. A selective small-molecule inhibitor of c-Jun N-terminal kinase 1.
    Yao K, Cho YY, Bode AM, Vummenthala A, Park JG, Liu K, Pang YP, Dong Z.
    FEBS Lett; 2009 Jul 07; 583(13):2208-12. PubMed ID: 19527717
    [Abstract] [Full Text] [Related]

  • 11. Implications for selectivity of 3,4-diarylquinolinones as p38alphaMAP kinase inhibitors.
    Peifer C, Urich R, Schattel V, Abadleh M, Röttig M, Kohlbacher O, Laufer S.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1431-5. PubMed ID: 18207396
    [Abstract] [Full Text] [Related]

  • 12. Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c-Jun N-terminal kinase 3 for potential treatment of neurodegenerative diseases.
    Muth F, Günther M, Bauer SM, Döring E, Fischer S, Maier J, Drückes P, Köppler J, Trappe J, Rothbauer U, Koch P, Laufer SA.
    J Med Chem; 2015 Jan 08; 58(1):443-56. PubMed ID: 25475894
    [Abstract] [Full Text] [Related]

  • 13. Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
    Probst GD, Bowers S, Sealy JM, Truong AP, Hom RK, Galemmo RA, Konradi AW, Sham HL, Quincy DA, Pan H, Yao N, Lin M, Tóth G, Artis DR, Zmolek W, Wong K, Qin A, Lorentzen C, Nakamura DF, Quinn KP, Sauer JM, Powell K, Ruslim L, Wright S, Chereau D, Ren Z, Anderson JP, Bard F, Yednock TA, Griswold-Prenner I.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):315-9. PubMed ID: 21112785
    [Abstract] [Full Text] [Related]

  • 14. The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
    Wrobleski ST, Lin S, Dhar TG, Dyckman AJ, Li T, Pitt S, Zhang R, Fan Y, Doweyko AM, Tokarski JS, Kish KF, Kiefer SE, Sack JS, Newitt JA, Witmer MR, McKinnon M, Barrish JC, Dodd JH, Schieven GL, Leftheris K.
    Bioorg Med Chem Lett; 2013 Jul 15; 23(14):4120-6. PubMed ID: 23746475
    [Abstract] [Full Text] [Related]

  • 15. Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
    Lin S, Wrobleski ST, Hynes J, Pitt S, Zhang R, Fan Y, Doweyko AM, Kish KF, Sack JS, Malley MF, Kiefer SE, Newitt JA, McKinnon M, Trzaskos J, Barrish JC, Dodd JH, Schieven GL, Leftheris K.
    Bioorg Med Chem Lett; 2010 Oct 01; 20(19):5864-8. PubMed ID: 20732813
    [Abstract] [Full Text] [Related]

  • 16. Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.
    Jerome KD, Hepperle ME, Walker JK, Xing L, Devraj RV, Benson AG, Baldus JE, Selness SR.
    Bioorg Med Chem Lett; 2010 May 15; 20(10):3146-9. PubMed ID: 20395140
    [Abstract] [Full Text] [Related]

  • 17. Biochemical and biophysical characterization of unique switch pocket inhibitors of p38α.
    Swann SL, Merta PJ, Kifle L, Groebe D, Sarris K, Hajduk PJ, Sun C.
    Bioorg Med Chem Lett; 2010 Oct 01; 20(19):5787-92. PubMed ID: 20471255
    [Abstract] [Full Text] [Related]

  • 18. Benzothiazole based inhibitors of p38alpha MAP kinase.
    Liu C, Lin J, Pitt S, Zhang RF, Sack JS, Kiefer SE, Kish K, Doweyko AM, Zhang H, Marathe PH, Trzaskos J, Mckinnon M, Dodd JH, Barrish JC, Schieven GL, Leftheris K.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1874-9. PubMed ID: 18296051
    [Abstract] [Full Text] [Related]

  • 19. Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
    Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J.
    Bioorg Med Chem Lett; 2006 Mar 01; 16(5):1397-401. PubMed ID: 16337120
    [Abstract] [Full Text] [Related]

  • 20. Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
    Herberich B, Cao GQ, Chakrabarti PP, Falsey JR, Pettus L, Rzasa RM, Reed AB, Reichelt A, Sham K, Thaman M, Wurz RP, Xu S, Zhang D, Hsieh F, Lee MR, Syed R, Li V, Grosfeld D, Plant MH, Henkle B, Sherman L, Middleton S, Wong LM, Tasker AS.
    J Med Chem; 2008 Oct 23; 51(20):6271-9. PubMed ID: 18817365
    [Abstract] [Full Text] [Related]

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