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Journal Abstract Search

496 related items for PubMed ID: 19318552

  • 1. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
    Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.
    Cancer Res; 2009 Apr 01; 69(7):3060-8. PubMed ID: 19318552
    [Abstract] [Full Text] [Related]

  • 2. Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines.
    Liu S, Breit S, Danckwardt S, Muckenthaler MU, Kulozik AE.
    Ann Hematol; 2009 Jul 01; 88(7):613-21. PubMed ID: 19057901
    [Abstract] [Full Text] [Related]

  • 3. In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.
    De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J.
    Haematologica; 2008 Apr 01; 93(4):533-42. PubMed ID: 18322257
    [Abstract] [Full Text] [Related]

  • 4. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.
    Hales EC, Taub JW, Matherly LH.
    Cell Signal; 2014 Jan 01; 26(1):149-61. PubMed ID: 24140475
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model.
    Groeneweg JW, Hall TR, Zhang L, Kim M, Byron VF, Tambouret R, Sathayanrayanan S, Foster R, Rueda BR, Growdon WB.
    Gynecol Oncol; 2014 Jun 01; 133(3):607-15. PubMed ID: 24667249
    [Abstract] [Full Text] [Related]

  • 6. Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.
    Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strack PR, Majumder PK.
    Br J Pharmacol; 2009 Nov 01; 158(5):1183-95. PubMed ID: 19775282
    [Abstract] [Full Text] [Related]

  • 7. Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells.
    Kogoshi H, Sato T, Koyama T, Nara N, Tohda S.
    Oncol Rep; 2007 Jul 01; 18(1):77-80. PubMed ID: 17549349
    [Abstract] [Full Text] [Related]

  • 8. Notch1 regulates chemotaxis and proliferation by controlling the CC-chemokine receptors 5 and 9 in T cell acute lymphoblastic leukaemia.
    Mirandola L, Chiriva-Internati M, Montagna D, Locatelli F, Zecca M, Ranzani M, Basile A, Locati M, Cobos E, Kast WM, Asselta R, Paraboschi EM, Comi P, Chiaramonte R.
    J Pathol; 2012 Apr 01; 226(5):713-22. PubMed ID: 21984373
    [Abstract] [Full Text] [Related]

  • 9. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
    Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK.
    Cancer Res; 2010 Mar 15; 70(6):2476-84. PubMed ID: 20197467
    [Abstract] [Full Text] [Related]

  • 10. Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.
    Guo D, Ye J, Dai J, Li L, Chen F, Ma D, Ji C.
    Leuk Res; 2009 May 15; 33(5):678-85. PubMed ID: 19091404
    [Abstract] [Full Text] [Related]

  • 11. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
    Lewis HD, Leveridge M, Strack PR, Haldon CD, O'neil J, Kim H, Madin A, Hannam JC, Look AT, Kohl N, Draetta G, Harrison T, Kerby JA, Shearman MS, Beher D.
    Chem Biol; 2007 Feb 15; 14(2):209-19. PubMed ID: 17317574
    [Abstract] [Full Text] [Related]

  • 12. Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.
    Cullion K, Draheim KM, Hermance N, Tammam J, Sharma VM, Ware C, Nikov G, Krishnamoorthy V, Majumder PK, Kelliher MA.
    Blood; 2009 Jun 11; 113(24):6172-81. PubMed ID: 19246562
    [Abstract] [Full Text] [Related]

  • 13. CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors.
    Palomero T, Barnes KC, Real PJ, Glade Bender JL, Sulis ML, Murty VV, Colovai AI, Balbin M, Ferrando AA.
    Leukemia; 2006 Jul 11; 20(7):1279-87. PubMed ID: 16688224
    [Abstract] [Full Text] [Related]

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  • 15. The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.
    Durinck K, Wallaert A, Van de Walle I, Van Loocke W, Volders PJ, Vanhauwaert S, Geerdens E, Benoit Y, Van Roy N, Poppe B, Soulier J, Cools J, Mestdagh P, Vandesompele J, Rondou P, Van Vlierberghe P, Taghon T, Speleman F.
    Haematologica; 2014 Dec 11; 99(12):1808-16. PubMed ID: 25344525
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  • 19. Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.
    Gusscott S, Kuchenbauer F, Humphries RK, Weng AP.
    Leuk Res; 2012 Jul 11; 36(7):905-11. PubMed ID: 22424712
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