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204 related items for PubMed ID: 1933868

  • 1. Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation.
    Mani C, Kupfer D.
    Cancer Res; 1991 Nov 15; 51(22):6052-8. PubMed ID: 1933868
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation.
    Mani C, Gelboin HV, Park SS, Pearce R, Parkinson A, Kupfer D.
    Drug Metab Dispos; 1993 Nov 15; 21(4):645-56. PubMed ID: 8104124
    [Abstract] [Full Text] [Related]

  • 3. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. II. Flavin-containing monooxygenase-mediated N-oxidation.
    Mani C, Hodgson E, Kupfer D.
    Drug Metab Dispos; 1993 Nov 15; 21(4):657-61. PubMed ID: 8104125
    [Abstract] [Full Text] [Related]

  • 4. Monooxygenase-mediated activation of chlorotrianisene (TACE) in covalent binding to rat hepatic microsomal proteins.
    Juedes MJ, Bulger WH, Kupfer D.
    Drug Metab Dispos; 1987 Nov 15; 15(6):786-93. PubMed ID: 2893703
    [Abstract] [Full Text] [Related]

  • 5. Oxidation of tamoxifen by human flavin-containing monooxygenase (FMO) 1 and FMO3 to tamoxifen-N-oxide and its novel reduction back to tamoxifen by human cytochromes P450 and hemoglobin.
    Parte P, Kupfer D.
    Drug Metab Dispos; 2005 Oct 15; 33(10):1446-52. PubMed ID: 15987777
    [Abstract] [Full Text] [Related]

  • 6. The aromatase inactivator 4-hydroxyandrostenedione (4-OH-A) inhibits tamoxifen metabolism by rat hepatic cytochrome P-450 3A: potential for drug-drug interaction of tamoxifen and 4-OH-A in combined anti-breast cancer therapy.
    Dehal SS, Brodie AM, Kupfer D.
    Drug Metab Dispos; 1999 Mar 15; 27(3):389-94. PubMed ID: 10064571
    [Abstract] [Full Text] [Related]

  • 7. Effect of cytochrome P-450 and flavin-containing monooxygenase modifying factors on the in vitro metabolism of amiodarone by rat and rabbit.
    Young RA, Mehendale HM.
    Drug Metab Dispos; 1987 Mar 15; 15(4):511-7. PubMed ID: 2888625
    [Abstract] [Full Text] [Related]

  • 8. Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
    Mani C, Pearce R, Parkinson A, Kupfer D.
    Carcinogenesis; 1994 Dec 15; 15(12):2715-20. PubMed ID: 8001226
    [Abstract] [Full Text] [Related]

  • 9. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS, Kupfer D.
    Cancer Res; 1997 Aug 15; 57(16):3402-6. PubMed ID: 9270005
    [Abstract] [Full Text] [Related]

  • 10. Concurrent flavin-containing monooxygenase down-regulation and cytochrome P-450 induction by dietary indoles in rat: implications for drug-drug interaction.
    Katchamart S, Stresser DM, Dehal SS, Kupfer D, Williams DE.
    Drug Metab Dispos; 2000 Aug 15; 28(8):930-6. PubMed ID: 10901703
    [Abstract] [Full Text] [Related]

  • 11. Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.
    Dehal SS, Kupfer D.
    Cancer Res; 1996 Mar 15; 56(6):1283-90. PubMed ID: 8640815
    [Abstract] [Full Text] [Related]

  • 12. Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism. Role of flavin-containing monooxygenase.
    Kedderis GL, Rickert DE.
    Drug Metab Dispos; 1985 Mar 15; 13(1):58-61. PubMed ID: 2858378
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of ketoconazole and deacetylated ketoconazole by rat hepatic microsomes and flavin-containing monooxygenases.
    Rodriguez RJ, Acosta D.
    Drug Metab Dispos; 1997 Jun 15; 25(6):772-7. PubMed ID: 9193882
    [Abstract] [Full Text] [Related]

  • 14. Flavin-containing monooxygenase-mediated N-oxidation of the M(1)-muscarinic agonist xanomeline.
    Ring BJ, Wrighton SA, Aldridge SL, Hansen K, Haehner B, Shipley LA.
    Drug Metab Dispos; 1999 Oct 15; 27(10):1099-103. PubMed ID: 10497134
    [Abstract] [Full Text] [Related]

  • 15. Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
    Masubuchi Y, Igarashi S, Suzuki T, Horie T, Narimatsu S.
    J Pharmacol Exp Ther; 1996 Nov 15; 279(2):724-31. PubMed ID: 8930177
    [Abstract] [Full Text] [Related]

  • 16. Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes.
    Onderwater RC, Commandeur JN, Menge WM, Vermeulen NP.
    Chem Res Toxicol; 1999 May 15; 12(5):396-402. PubMed ID: 10328749
    [Abstract] [Full Text] [Related]

  • 17. Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole.
    Woodcroft KJ, Webb CD, Yao M, Weedon AC, Bend JR.
    Chem Res Toxicol; 1997 May 15; 10(5):589-99. PubMed ID: 9168258
    [Abstract] [Full Text] [Related]

  • 18. Sulfoxidation of mercapturic acids derived from tri- and tetrachloroethene by cytochromes P450 3A: a bioactivation reaction in addition to deacetylation and cysteine conjugate beta-lyase mediated cleavage.
    Werner M, Birner G, Dekant W.
    Chem Res Toxicol; 1996 May 15; 9(1):41-9. PubMed ID: 8924615
    [Abstract] [Full Text] [Related]

  • 19. Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.
    Weber GF, Waxman DJ.
    Arch Biochem Biophys; 1993 Dec 15; 307(2):369-78. PubMed ID: 8274024
    [Abstract] [Full Text] [Related]

  • 20. Characteristics of monooxygenase-mediated covalent binding of methoxychlor in human and rat liver microsomes.
    Bulger WH, Kupfer D.
    Drug Metab Dispos; 1989 Dec 15; 17(5):487-94. PubMed ID: 2573491
    [Abstract] [Full Text] [Related]

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