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202 related items for PubMed ID: 19351161

  • 1. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.
    Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.
    Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161
    [Abstract] [Full Text] [Related]

  • 2. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    J Antimicrob Chemother; 1999 Jan 02; 43(1):23-9. PubMed ID: 10381097
    [Abstract] [Full Text] [Related]

  • 3. Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.
    Thomson JM, Distler AM, Prati F, Bonomo RA.
    J Biol Chem; 2006 Sep 08; 281(36):26734-44. PubMed ID: 16803899
    [Abstract] [Full Text] [Related]

  • 4. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 5. X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid.
    Swarén P, Golemi D, Cabantous S, Bulychev A, Maveyraud L, Mobashery S, Samama JP.
    Biochemistry; 1999 Jul 27; 38(30):9570-6. PubMed ID: 10423234
    [Abstract] [Full Text] [Related]

  • 6. Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
    Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA.
    J Biol Chem; 2005 Oct 21; 280(42):35528-36. PubMed ID: 15987690
    [Abstract] [Full Text] [Related]

  • 7. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 8. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
    Li M, Conklin BC, Taracila MA, Hutton RA, Skalweit MJ.
    Antimicrob Agents Chemother; 2012 Nov 26; 56(11):5678-86. PubMed ID: 22908166
    [Abstract] [Full Text] [Related]

  • 9. Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
    Vakulenko SB, Geryk B, Kotra LP, Mobashery S, Lerner SA.
    Antimicrob Agents Chemother; 1998 Jul 26; 42(7):1542-8. PubMed ID: 9660980
    [Abstract] [Full Text] [Related]

  • 10. Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
    Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Jul 26; 54(7):2867-77. PubMed ID: 20421396
    [Abstract] [Full Text] [Related]

  • 11. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.
    Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA.
    Antimicrob Agents Chemother; 2012 Aug 26; 56(8):4428-38. PubMed ID: 22687511
    [Abstract] [Full Text] [Related]

  • 12. Avibactam and inhibitor-resistant SHV β-lactamases.
    Winkler ML, Papp-Wallace KM, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 26; 59(7):3700-9. PubMed ID: 25691639
    [Abstract] [Full Text] [Related]

  • 13. Phenotypic study of resistance of beta-lactamase-inhibitor-resistant TEM enzymes which differ by naturally occurring variations and by site-directed substitution at Asp276.
    Caniça MM, Caroff N, Barthélémy M, Labia R, Krishnamoorthy R, Paul G, Dupret JM.
    Antimicrob Agents Chemother; 1998 Jun 26; 42(6):1323-8. PubMed ID: 9624468
    [Abstract] [Full Text] [Related]

  • 14. Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase.
    Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA.
    J Med Chem; 2013 Feb 14; 56(3):1084-97. PubMed ID: 23252553
    [Abstract] [Full Text] [Related]

  • 15. OHIO-1 beta-lactamase mutants: the Arg244Ser mutant and resistance to beta-lactams and beta-lactamase inhibitors.
    Lin S, Thomas M, Mark S, Anderson V, Bonomo RA.
    Biochim Biophys Acta; 1999 Jun 15; 1432(1):125-36. PubMed ID: 10366735
    [Abstract] [Full Text] [Related]

  • 16. Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
    Manageiro V, Ferreira E, Cougnoux A, Albuquerque L, Caniça M, Bonnet R.
    Antimicrob Agents Chemother; 2012 Feb 15; 56(2):1042-6. PubMed ID: 22083476
    [Abstract] [Full Text] [Related]

  • 17. Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.
    Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.
    Antimicrob Agents Chemother; 2011 Jul 15; 55(7):3465-75. PubMed ID: 21555770
    [Abstract] [Full Text] [Related]

  • 18. beta-Lactamase mutations far from the active site influence inhibitor binding.
    Bonomo RA, Dawes CG, Knox JR, Shlaes DM.
    Biochim Biophys Acta; 1995 Feb 22; 1247(1):121-5. PubMed ID: 7873581
    [Abstract] [Full Text] [Related]

  • 19. Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
    Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR.
    Biochemistry; 2007 Jul 24; 46(29):8689-99. PubMed ID: 17595114
    [Abstract] [Full Text] [Related]

  • 20. Elucidating the role of Trp105 in the KPC-2 β-lactamase.
    Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA.
    Protein Sci; 2010 Sep 24; 19(9):1714-27. PubMed ID: 20662006
    [Abstract] [Full Text] [Related]

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