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Journal Abstract Search

187 related items for PubMed ID: 19358519

  • 1. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile.
    Wang Y, Zhong D, Chen X, Zheng J.
    Chem Res Toxicol; 2009 May; 22(5):824-34. PubMed ID: 19358519
    [Abstract] [Full Text] [Related]

  • 2. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [Abstract] [Full Text] [Related]

  • 3. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
    Shen Q, Zuo M, Ma L, Tian Y, Wang L, Jiang H, Zhou Q, Zhou H, Yu L, Zeng S.
    Chem Biol Interact; 2014 Dec 05; 224():89-99. PubMed ID: 25451576
    [Abstract] [Full Text] [Related]

  • 4. Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice.
    Jin H, Dai J, Chen X, Liu J, Zhong D, Gu Y, Zheng J.
    J Pharmacol Exp Ther; 2010 Mar 05; 332(3):738-46. PubMed ID: 20008063
    [Abstract] [Full Text] [Related]

  • 5. Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho-benzoquinone metabolites in human liver microsomes.
    Deng P, Zhong D, Nan F, Liu S, Li D, Yuan T, Chen X, Zheng J.
    Chem Res Toxicol; 2010 Oct 18; 23(10):1617-28. PubMed ID: 20843008
    [Abstract] [Full Text] [Related]

  • 6. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
    Wen B, Chen Y, Fitch WL.
    Drug Metab Dispos; 2009 Jul 18; 37(7):1557-62. PubMed ID: 19364830
    [Abstract] [Full Text] [Related]

  • 7. CYP3A-mediated apoptosis of dauricine in cultured human bronchial epithelial cells and in lungs of CD-1 mice.
    Jin H, Shen S, Chen X, Zhong D, Zheng J.
    Toxicol Appl Pharmacol; 2012 Jun 15; 261(3):248-54. PubMed ID: 22521607
    [Abstract] [Full Text] [Related]

  • 8. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS.
    Chem Res Toxicol; 2007 Nov 15; 20(11):1649-57. PubMed ID: 17907785
    [Abstract] [Full Text] [Related]

  • 9. Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.
    Wen B, Moore DJ.
    Drug Metab Dispos; 2011 Sep 15; 39(9):1511-21. PubMed ID: 21628497
    [Abstract] [Full Text] [Related]

  • 10. Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice.
    Jin H, Li L, Zhong D, Liu J, Chen X, Zheng J.
    Chem Res Toxicol; 2011 Dec 19; 24(12):2142-52. PubMed ID: 21992520
    [Abstract] [Full Text] [Related]

  • 11. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
    Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL.
    Chem Res Toxicol; 2005 Feb 19; 18(2):174-82. PubMed ID: 15720121
    [Abstract] [Full Text] [Related]

  • 12. Identification of amino acid and glutathione N-conjugates of toosendanin: bioactivation of the furan ring mediated by CYP3A4.
    Yu J, Deng P, Zhong D, Chen X.
    Chem Res Toxicol; 2014 Sep 15; 27(9):1598-609. PubMed ID: 25105339
    [Abstract] [Full Text] [Related]

  • 13. In vitro and in vivo metabolic activation of berbamine to quinone methide intermediate.
    Sun Y, Yao T, Li H, Peng Y, Zheng J.
    J Biochem Mol Toxicol; 2017 Apr 15; 31(4):. PubMed ID: 27902864
    [Abstract] [Full Text] [Related]

  • 14. Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate.
    Gunduz M, Argikar UA, Kamel A, Colizza K, Bushee JL, Cirello A, Lombardo F, Harriman S.
    Drug Metab Dispos; 2012 Nov 15; 40(11):2074-80. PubMed ID: 22851614
    [Abstract] [Full Text] [Related]

  • 15. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
    Iverson SL, Shen L, Anlar N, Bolton JL.
    Chem Res Toxicol; 1996 Mar 15; 9(2):492-9. PubMed ID: 8839054
    [Abstract] [Full Text] [Related]

  • 16. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
    Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.
    Chem Res Toxicol; 2001 Jan 15; 14(1):62-70. PubMed ID: 11170509
    [Abstract] [Full Text] [Related]

  • 17. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q, Zhu M.
    Chem Res Toxicol; 2010 May 17; 23(5):909-17. PubMed ID: 20297803
    [Abstract] [Full Text] [Related]

  • 18. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
    Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W.
    Drug Metab Dispos; 2006 Jan 17; 34(1):145-51. PubMed ID: 16251255
    [Abstract] [Full Text] [Related]

  • 19. Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
    Chen H, Grover S, Yu L, Walker G, Mutlib A.
    Chem Res Toxicol; 2010 Jan 17; 23(1):159-70. PubMed ID: 19961160
    [Abstract] [Full Text] [Related]

  • 20. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar 17; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

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