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Journal Abstract Search

333 related items for PubMed ID: 19364830

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  • 9. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS.
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
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  • 10. Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.
    Dekker SJ, Zhang Y, Vos JC, Vermeulen NP, Commandeur JN.
    Chem Res Toxicol; 2016 Dec 19; 29(12):2136-2144. PubMed ID: 27989146
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  • 11. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
    Shen Q, Zuo M, Ma L, Tian Y, Wang L, Jiang H, Zhou Q, Zhou H, Yu L, Zeng S.
    Chem Biol Interact; 2014 Dec 05; 224():89-99. PubMed ID: 25451576
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  • 12. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile.
    Wang Y, Zhong D, Chen X, Zheng J.
    Chem Res Toxicol; 2009 May 05; 22(5):824-34. PubMed ID: 19358519
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  • 13. Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate.
    Gunduz M, Argikar UA, Kamel A, Colizza K, Bushee JL, Cirello A, Lombardo F, Harriman S.
    Drug Metab Dispos; 2012 Nov 05; 40(11):2074-80. PubMed ID: 22851614
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  • 14. Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.
    Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W.
    Chem Res Toxicol; 2002 Jul 05; 15(7):907-14. PubMed ID: 12119000
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  • 15. Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho-benzoquinone metabolites in human liver microsomes.
    Deng P, Zhong D, Nan F, Liu S, Li D, Yuan T, Chen X, Zheng J.
    Chem Res Toxicol; 2010 Oct 18; 23(10):1617-28. PubMed ID: 20843008
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  • 16. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS, Vermeulen NP, Commandeur JN.
    Chem Biol Interact; 2014 Jan 25; 207():32-40. PubMed ID: 24246759
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  • 17. Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.
    Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS.
    Chem Res Toxicol; 2005 Sep 25; 18(9):1427-37. PubMed ID: 16167835
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  • 18. Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.
    Wen B, Moore DJ.
    Drug Metab Dispos; 2011 Sep 25; 39(9):1511-21. PubMed ID: 21628497
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  • 19. In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.
    Mahajan MK, Uttamsingh V, Daniels JS, Gan LS, LeDuc BW, Williams DA.
    Drug Metab Dispos; 2011 Apr 25; 39(4):693-702. PubMed ID: 21177487
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  • 20. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
    Yan Z, Zhong HM, Maher N, Torres R, Leo GC, Caldwell GW, Huebert N.
    Drug Metab Dispos; 2005 Dec 25; 33(12):1867-76. PubMed ID: 16174805
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