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201 related items for PubMed ID: 19371349

  • 1. Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro.
    Räikkönen J, Crockett JC, Rogers MJ, Mönkkönen H, Auriola S, Mönkkönen J.
    Br J Pharmacol; 2009 Jun; 157(3):427-35. PubMed ID: 19371349
    [Abstract] [Full Text] [Related]

  • 2. Zoledronic acid-induced IPP/ApppI production in vivo.
    Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I.
    Life Sci; 2007 Sep 08; 81(13):1066-70. PubMed ID: 17850825
    [Abstract] [Full Text] [Related]

  • 3. Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth.
    Mönkkönen H, Kuokkanen J, Holen I, Evans A, Lefley DV, Jauhiainen M, Auriola S, Mönkkönen J.
    Anticancer Drugs; 2008 Apr 08; 19(4):391-9. PubMed ID: 18454049
    [Abstract] [Full Text] [Related]

  • 4. The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro.
    Mitrofan LM, Pelkonen J, Mönkkönen J.
    Bone; 2009 Dec 08; 45(6):1153-60. PubMed ID: 19699819
    [Abstract] [Full Text] [Related]

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  • 6. High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.
    Benzaïd I, Mönkkönen H, Stresing V, Bonnelye E, Green J, Mönkkönen J, Touraine JL, Clézardin P.
    Cancer Res; 2011 Jul 01; 71(13):4562-72. PubMed ID: 21646473
    [Abstract] [Full Text] [Related]

  • 7. Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells.
    Räikkönen J, Mönkkönen H, Auriola S, Mönkkönen J.
    Biochem Pharmacol; 2010 Mar 01; 79(5):777-83. PubMed ID: 19819230
    [Abstract] [Full Text] [Related]

  • 8. Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells.
    Ebert R, Meissner-Weigl J, Zeck S, Määttä J, Auriola S, Coimbra de Sousa S, Mentrup B, Graser S, Rachner TD, Hofbauer LC, Jakob F.
    Mol Cancer; 2014 Dec 11; 13():265. PubMed ID: 25496233
    [Abstract] [Full Text] [Related]

  • 9. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.
    Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J.
    Br J Pharmacol; 2006 Feb 11; 147(4):437-45. PubMed ID: 16402039
    [Abstract] [Full Text] [Related]

  • 10. Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells.
    Mitrofan LM, Castells FB, Pelkonen J, Mönkkönen J.
    J Biol Chem; 2010 Jan 15; 285(3):1967-79. PubMed ID: 19875454
    [Abstract] [Full Text] [Related]

  • 11. Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen.
    Vantourout P, Mookerjee-Basu J, Rolland C, Pont F, Martin H, Davrinche C, Martinez LO, Perret B, Collet X, Périgaud C, Peyrottes S, Champagne E.
    J Immunol; 2009 Sep 15; 183(6):3848-57. PubMed ID: 19710470
    [Abstract] [Full Text] [Related]

  • 12. Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells.
    Zlatev HP, Auriola S, Mönkkönen J, Määttä JA.
    Eur J Pharm Sci; 2016 Apr 30; 86():58-66. PubMed ID: 26957415
    [Abstract] [Full Text] [Related]

  • 13. Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
    Räikkönen J, Taskinen M, Dunford JE, Mönkkönen H, Auriola S, Mönkkönen J.
    Biochem Biophys Res Commun; 2011 Apr 22; 407(4):663-7. PubMed ID: 21420384
    [Abstract] [Full Text] [Related]

  • 14. In vivo phosphoantigen levels in bisphosphonate-treated human breast tumors trigger Vγ9Vδ2 T-cell antitumor cytotoxicity through ICAM-1 engagement.
    Benzaïd I, Mönkkönen H, Bonnelye E, Mönkkönen J, Clézardin P.
    Clin Cancer Res; 2012 Nov 15; 18(22):6249-59. PubMed ID: 23032740
    [Abstract] [Full Text] [Related]

  • 15. The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis.
    Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ.
    Arthritis Rheum; 2001 Sep 15; 44(9):2201-10. PubMed ID: 11592386
    [Abstract] [Full Text] [Related]

  • 16. Bisphosphonates: the first 40 years.
    Russell RG.
    Bone; 2011 Jul 15; 49(1):2-19. PubMed ID: 21555003
    [Abstract] [Full Text] [Related]

  • 17. In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts.
    Kellinsalmi M, Mönkkönen H, Mönkkönen J, Leskelä HV, Parikka V, Hämäläinen M, Lehenkari P.
    Basic Clin Pharmacol Toxicol; 2005 Dec 15; 97(6):382-91. PubMed ID: 16364054
    [Abstract] [Full Text] [Related]

  • 18. Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.
    Roelofs AJ, Jauhiainen M, Mönkkönen H, Rogers MJ, Mönkkönen J, Thompson K.
    Br J Haematol; 2009 Jan 15; 144(2):245-50. PubMed ID: 19016713
    [Abstract] [Full Text] [Related]

  • 19. Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced Vγ9Vδ2 T cell cytotoxicity in PC-3 prostate cancer cells.
    Arkko S, Zlatev HP, Mönkkönen H, Räikkönen J, Benzaïd I, Clézardin P, Mönkkönen J, Määttä JA.
    Cancer Lett; 2015 Feb 01; 357(1):279-285. PubMed ID: 25444923
    [Abstract] [Full Text] [Related]

  • 20. The molecular basis of bisphosphonate activity: a preclinical perspective.
    Green J, Clézardin P.
    Semin Oncol; 2010 Jun 01; 37 Suppl 1():S3-11. PubMed ID: 20682369
    [Abstract] [Full Text] [Related]

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