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Journal Abstract Search

130 related items for PubMed ID: 19376115

  • 1. An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
    Suzuki Y, Ohta K, Itoh M, Sakoh-Sumitomo Y, Mitsuda T, Ueda M, Hayakawa-Yano Y, Li S, Hida Y, Inuzuka T, Jung YK, Nakagawa T.
    FEBS Lett; 2009 May 06; 583(9):1403-8. PubMed ID: 19376115
    [Abstract] [Full Text] [Related]

  • 2. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.
    J Neurochem; 2005 Nov 06; 95(3):880-90. PubMed ID: 16135086
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  • 3. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul 06; 110(1):275-83. PubMed ID: 19457123
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  • 4. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.
    Neurobiol Dis; 2007 Jul 06; 27(1):102-7. PubMed ID: 17560791
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  • 5. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
    Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A.
    J Neurochem; 2006 Jan 06; 96(1):218-27. PubMed ID: 16305624
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  • 8. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
    Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C.
    EMBO J; 2004 Dec 08; 23(24):4738-48. PubMed ID: 15549135
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  • 9. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
    Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.
    FEBS J; 2005 Nov 08; 272(21):5544-57. PubMed ID: 16262694
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  • 10. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation.
    Walker ES, Martinez M, Wang J, Goate A.
    J Neurochem; 2006 Jul 08; 98(1):300-9. PubMed ID: 16805816
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  • 12. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
    Prokop S, Haass C, Steiner H.
    J Neurochem; 2005 Jul 08; 94(1):57-62. PubMed ID: 15953349
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  • 13. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB, Franko M, Banks WA, Kasinadhuni P, Farr SA, Vyas K, Choudhuri V, Morley JE.
    J Exp Biol; 2009 Feb 08; 212(Pt 4):494-8. PubMed ID: 19181896
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  • 15. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
    Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H.
    Biochemistry; 2009 Feb 17; 48(6):1183-97. PubMed ID: 19159235
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  • 16. p53 is regulated by and regulates members of the gamma-secretase complex.
    Checler F, Dunys J, Pardossi-Piquard R, Alves da Costa C.
    Neurodegener Dis; 2010 Feb 17; 7(1-3):50-5. PubMed ID: 20160459
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  • 17. Analysis of alteration of p75NTR processing and signalling by PS2 mutation and gamma-secretase inhibition.
    Ito Y, Ishii A, Passmore AP, McIlroy SP.
    Neurobiol Dis; 2007 Sep 17; 27(3):258-64. PubMed ID: 17582777
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  • 18. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.
    Nadler Y, Alexandrovich A, Grigoriadis N, Hartmann T, Rao KS, Shohami E, Stein R.
    Glia; 2008 Apr 17; 56(5):552-67. PubMed ID: 18240300
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  • 20. From presenilinase to gamma-secretase, cleave to capacitate.
    Xia W.
    Curr Alzheimer Res; 2008 Apr 17; 5(2):172-8. PubMed ID: 18393802
    [Abstract] [Full Text] [Related]

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