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212 related items for PubMed ID: 19391634

  • 1. Proteochemometric modeling of drug resistance over the mutational space for multiple HIV protease variants and multiple protease inhibitors.
    Lapins M, Wikberg JE.
    J Chem Inf Model; 2009 May; 49(5):1202-10. PubMed ID: 19391634
    [Abstract] [Full Text] [Related]

  • 2. Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments.
    Garriga C, Pérez-Elías MJ, Delgado R, Ruiz L, Nájera R, Pumarola T, Alonso-Socas Mdel M, García-Bujalance S, Menéndez-Arias L, Spanish Group for the Study of Antiretroviral Drug Resistance.
    J Med Virol; 2007 Nov; 79(11):1617-28. PubMed ID: 17854027
    [Abstract] [Full Text] [Related]

  • 3. Persistence of mutations during replication of an HIV library containing combinations of selected protease mutations.
    Song W, Maeda Y, Tenpaku A, Harada S, Yusa K.
    Antiviral Res; 2004 Mar; 61(3):173-80. PubMed ID: 15168798
    [Abstract] [Full Text] [Related]

  • 4. Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.
    Ohtaka H, Schön A, Freire E.
    Biochemistry; 2003 Nov 25; 42(46):13659-66. PubMed ID: 14622012
    [Abstract] [Full Text] [Related]

  • 5. Some insights into mechanism for binding and drug resistance of wild type and I50V V82A and I84V mutations in HIV-1 protease with GRL-98065 inhibitor from molecular dynamic simulations.
    Hu GD, Zhu T, Zhang SL, Wang D, Zhang QG.
    Eur J Med Chem; 2010 Jan 25; 45(1):227-35. PubMed ID: 19910081
    [Abstract] [Full Text] [Related]

  • 6. Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
    Clemente JC, Moose RE, Hemrajani R, Whitford LR, Govindasamy L, Reutzel R, McKenna R, Agbandje-McKenna M, Goodenow MM, Dunn BM.
    Biochemistry; 2004 Sep 28; 43(38):12141-51. PubMed ID: 15379553
    [Abstract] [Full Text] [Related]

  • 7. Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants.
    Kozísek M, Bray J, Rezácová P, Sasková K, Brynda J, Pokorná J, Mammano F, Rulísek L, Konvalinka J.
    J Mol Biol; 2007 Dec 07; 374(4):1005-16. PubMed ID: 17977555
    [Abstract] [Full Text] [Related]

  • 8. Novel human immunodeficiency virus type 1 protease mutations potentially involved in resistance to protease inhibitors.
    Svicher V, Ceccherini-Silberstein F, Erba F, Santoro M, Gori C, Bellocchi MC, Giannella S, Trotta MP, Monforte Ad, Antinori A, Perno CF.
    Antimicrob Agents Chemother; 2005 May 07; 49(5):2015-25. PubMed ID: 15855527
    [Abstract] [Full Text] [Related]

  • 9. Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants.
    Majerová-Uhlíková T, Dantuma NP, Lindsten K, Masucci MG, Konvalinka J.
    J Clin Virol; 2006 May 07; 36(1):50-9. PubMed ID: 16527535
    [Abstract] [Full Text] [Related]

  • 10. Computational simulations of HIV-1 proteases--multi-drug resistance due to nonactive site mutation L90M.
    Ode H, Neya S, Hata M, Sugiura W, Hoshino T.
    J Am Chem Soc; 2006 Jun 21; 128(24):7887-95. PubMed ID: 16771502
    [Abstract] [Full Text] [Related]

  • 11. Systematic molecular dynamics, MM-PBSA, and ab initio approaches to the saquinavir resistance mechanism in HIV-1 PR due to 11 double and multiple mutations.
    Tzoupis H, Leonis G, Avramopoulos A, Mavromoustakos T, Papadopoulos MG.
    J Phys Chem B; 2014 Aug 14; 118(32):9538-52. PubMed ID: 25036111
    [Abstract] [Full Text] [Related]

  • 12. Genotype dependent QSAR for HIV-1 protease inhibition.
    Boutton CW, De Bondt HL, De Jonge MR.
    J Med Chem; 2005 Mar 24; 48(6):2115-20. PubMed ID: 15771454
    [Abstract] [Full Text] [Related]

  • 13. The HIV-1 protease substitution K55R: a protease-inhibitor-associated substitution involved in restoring viral replication.
    Margerison ES, Maguire M, Pillay D, Cane P, Elston RC.
    J Antimicrob Chemother; 2008 Apr 24; 61(4):786-91. PubMed ID: 18252693
    [Abstract] [Full Text] [Related]

  • 14. Resistant mechanism against nelfinavir of human immunodeficiency virus type 1 proteases.
    Ode H, Ota M, Neya S, Hata M, Sugiura W, Hoshino T.
    J Phys Chem B; 2005 Jan 13; 109(1):565-74. PubMed ID: 16851048
    [Abstract] [Full Text] [Related]

  • 15. PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study.
    Dandache S, Coburn CA, Oliveira M, Allison TJ, Holloway MK, Wu JJ, Stranix BR, Panchal C, Wainberg MA, Vacca JP.
    J Med Virol; 2008 Dec 13; 80(12):2053-63. PubMed ID: 19040279
    [Abstract] [Full Text] [Related]

  • 16. False I50V resistance readings of HIV isolates: co-amplification of NASBA HIV-1 RNA QT internal calibrators and HIV-1 patient isolates may lead to a false I50V mutation resistance reading in genotypic tests.
    Waléria-Aleixo A, Greco DB, Brindeiro R, Tanuri A.
    Arch Virol; 2008 Dec 13; 153(8):1489-94. PubMed ID: 18600296
    [Abstract] [Full Text] [Related]

  • 17. Structural and kinetic analysis of pyrrolidine-based inhibitors of the drug-resistant Ile84Val mutant of HIV-1 protease.
    Böttcher J, Blum A, Heine A, Diederich WE, Klebe G.
    J Mol Biol; 2008 Nov 07; 383(2):347-57. PubMed ID: 18692068
    [Abstract] [Full Text] [Related]

  • 18. Discordant genotypic interpretation and phenotypic role of protease mutations in HIV-1 subtypes B and G.
    Santos AF, Abecasis AB, Vandamme AM, Camacho RJ, Soares MA.
    J Antimicrob Chemother; 2009 Mar 07; 63(3):593-9. PubMed ID: 19136678
    [Abstract] [Full Text] [Related]

  • 19. Molecular dynamic and free energy studies of primary resistance mutations in HIV-1 protease-ritonavir complexes.
    Aruksakunwong O, Wolschann P, Hannongbua S, Sompornpisut P.
    J Chem Inf Model; 2006 Mar 07; 46(5):2085-92. PubMed ID: 16995739
    [Abstract] [Full Text] [Related]

  • 20. Structural insights into the mechanisms of drug resistance in HIV-1 protease NL4-3.
    Heaslet H, Kutilek V, Morris GM, Lin YC, Elder JH, Torbett BE, Stout CD.
    J Mol Biol; 2006 Mar 03; 356(4):967-81. PubMed ID: 16403521
    [Abstract] [Full Text] [Related]

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