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Journal Abstract Search

269 related items for PubMed ID: 19398331

  • 1. The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
    McGuigan C, Daverio F, Nájera I, Martin JA, Klumpp K, Smith DB.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3122-4. PubMed ID: 19398331
    [Abstract] [Full Text] [Related]

  • 2. Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
    Perrone P, Luoni GM, Kelleher MR, Daverio F, Angell A, Mulready S, Congiatu C, Rajyaguru S, Martin JA, Levêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C.
    J Med Chem; 2007 Apr 19; 50(8):1840-9. PubMed ID: 17367121
    [Abstract] [Full Text] [Related]

  • 3. Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
    McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.
    J Med Chem; 2010 Jul 08; 53(13):4949-57. PubMed ID: 20527890
    [Abstract] [Full Text] [Related]

  • 4. First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
    Perrone P, Daverio F, Valente R, Rajyaguru S, Martin JA, Lévêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C.
    J Med Chem; 2007 Nov 01; 50(22):5463-70. PubMed ID: 17914786
    [Abstract] [Full Text] [Related]

  • 5. The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
    McGuigan C, Perrone P, Madela K, Neyts J.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4316-20. PubMed ID: 19523820
    [Abstract] [Full Text] [Related]

  • 6. Phosphoramidate protides of carbocyclic 2',3'-dideoxy-2',3'-didehydro-7-deazaadenosine with potent activity against HIV and HBV.
    Gudmundsson KS, Wang Z, Daluge SM, Johnson LC, Hazen R, Condreay LD, McGuigan C.
    Nucleosides Nucleotides Nucleic Acids; 2004 Aug 01; 23(12):1929-37. PubMed ID: 15628749
    [Abstract] [Full Text] [Related]

  • 7. Evaluation of novel phosphoramidate ProTides of the 2'-fluoro derivatives of a potent anti-varicella zoster virus bicyclic nucleoside analogue.
    Derudas M, Quintiliani M, Brancale A, Andrei G, Snoeck R, Balzarini J, McGuigan C.
    Antivir Chem Chemother; 2010 Oct 28; 21(1):15-31. PubMed ID: 21045257
    [Abstract] [Full Text] [Related]

  • 8. Phosphoramidate protides of 2',3'-dideoxy-3'-fluoroadenosine and related nucleosides with potent activity against HIV and HBV.
    Gudmundsson KS, Daluge SM, Johnson LC, Jansen R, Hazen R, Condreay LD, McGuigan C.
    Nucleosides Nucleotides Nucleic Acids; 2003 Oct 28; 22(10):1953-61. PubMed ID: 14609234
    [Abstract] [Full Text] [Related]

  • 9. Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
    Gardelli C, Attenni B, Donghi M, Meppen M, Pacini B, Harper S, Di Marco A, Fiore F, Giuliano C, Pucci V, Laufer R, Gennari N, Marcucci I, Leone JF, Olsen DB, MacCoss M, Rowley M, Narjes F.
    J Med Chem; 2009 Sep 10; 52(17):5394-407. PubMed ID: 19725579
    [Abstract] [Full Text] [Related]

  • 10. Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
    McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.
    Bioorg Med Chem Lett; 2011 Oct 01; 21(19):6007-12. PubMed ID: 21856153
    [Abstract] [Full Text] [Related]

  • 11. Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells.
    Mehellou Y, Balzarini J, McGuigan C.
    ChemMedChem; 2009 Nov 01; 4(11):1779-91. PubMed ID: 19760699
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and anti-herpetic activity of phosphoramidate ProTides.
    Maiti M, Persoons L, Andrei G, Snoeck R, Balzarini J, Herdewijn P.
    ChemMedChem; 2013 Jun 01; 8(6):985-93. PubMed ID: 23606629
    [Abstract] [Full Text] [Related]

  • 13. The design, synthesis and antiviral evaluation of a series of 5-trimethylsilyl-1-beta-D-(arabinofuranosyl)uracil phosphoramidate ProTides.
    Mehellou Y, Balzarini J, McGuigan C.
    Antivir Chem Chemother; 2010 Mar 09; 20(4):153-60. PubMed ID: 20231780
    [Abstract] [Full Text] [Related]

  • 14. A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.
    Sun Q, Li X, Gong S, Liu G, Shen L, Peng L.
    Nucleosides Nucleotides Nucleic Acids; 2013 Mar 09; 32(11):617-38. PubMed ID: 24138500
    [Abstract] [Full Text] [Related]

  • 15. Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
    McGuigan C, Derudas M, Bugert JJ, Andrei G, Snoeck R, Balzarini J.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4364-7. PubMed ID: 18614365
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
    Bourdin C, McGuigan C, Brancale A, Chamberlain S, Vernachio J, Hutchins J, Gorovits E, Kolykhalov A, Muhammad J, Patti J, Henson G, Bleiman B, Bryant KD, Ganguly B, Hunley D, Obikhod A, Walters CR, Wang J, Ramamurty CV, Battina SK, Srivinas Rao C.
    Bioorg Med Chem Lett; 2013 Apr 01; 23(7):2260-4. PubMed ID: 23453067
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and anti-HCV activity of a series of β-d-2'-deoxy-2'-dibromo nucleosides and their corresponding phosphoramidate prodrugs.
    Chen Z, Cox BD, Garnier-Amblard EC, McBrayer TR, Coats SJ, Schinazi RF, Amblard F.
    Bioorg Med Chem Lett; 2017 Dec 01; 27(23):5296-5299. PubMed ID: 29066308
    [Abstract] [Full Text] [Related]

  • 18. Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction.
    Pertusati F, McGuigan C.
    Chem Commun (Camb); 2015 May 11; 51(38):8070-3. PubMed ID: 25867944
    [Abstract] [Full Text] [Related]

  • 19. Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.
    Maiti M, Maiti M, Rozenski J, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2015 May 14; 13(18):5158-74. PubMed ID: 25849139
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
    McGuigan C, Madela K, Aljarah M, Gilles A, Brancale A, Zonta N, Chamberlain S, Vernachio J, Hutchins J, Hall A, Ames B, Gorovits E, Ganguly B, Kolykhalov A, Wang J, Muhammad J, Patti JM, Henson G.
    Bioorg Med Chem Lett; 2010 Aug 15; 20(16):4850-4. PubMed ID: 20637609
    [Abstract] [Full Text] [Related]

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