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118 related items for PubMed ID: 1940644

  • 1. Inhibitors of sterol synthesis. Characterization of beta,gamma-unsaturated analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Wilson WK, Wheeler ME, Pinkerton FD, St Pyrek J, Schroepfer GJ.
    J Lipid Res; 1991 Jul; 32(7):1215-27. PubMed ID: 1940644
    [Abstract] [Full Text] [Related]

  • 2. Inhibitors of sterol synthesis. Chemical synthesis and properties of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Swaminathan S, Wilson WK, Pinkerton FD, Gerst N, Ramser M, Schroepfer GJ.
    J Lipid Res; 1993 Oct; 34(10):1805-23. PubMed ID: 8245728
    [Abstract] [Full Text] [Related]

  • 3. Inhibitors of sterol synthesis: synthesis and spectral properties of derivatives of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one fluorinated at carbon 7 or carbon 9 and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Siddiqui AU, Swaminathan S, Pinkerton FD, Gerst N, Wilson WK, Choi H, Schroephfer GJ.
    Chem Phys Lipids; 1994 Jun 24; 72(1):59-75. PubMed ID: 7923480
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Numazawa S, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Oct 24; 33(10):1503-15. PubMed ID: 1431575
    [Abstract] [Full Text] [Related]

  • 5. Inhibitors of sterol synthesis. Chemical synthesis of 7 alpha-ethyl and 16 alpha-ethyl derivatives of delta 8(14)-15-oxygenated sterols and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase in CHO-K1 cells.
    Kim HS, Wilson WK, Kirkpatrick ND, Pinkerton FD, Swaminathan S, Hylarides MD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Jul 24; 62(1):55-67. PubMed ID: 1423803
    [Abstract] [Full Text] [Related]

  • 6. Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5 alpha-cholest-8(14)-ene-3 beta,15 beta,26-triol, a potential metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells.
    Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1992 May 24; 61(3):235-42. PubMed ID: 1525963
    [Abstract] [Full Text] [Related]

  • 7. Inhibitors of sterol synthesis. Chemical syntheses and spectral properties of 26-oxygenated derivatives of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Siddiqui AU, Wilson WK, Ruecker KE, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1992 Nov 24; 63(1-2):77-90. PubMed ID: 1486662
    [Abstract] [Full Text] [Related]

  • 8. Inhibitors of sterol synthesis. A highly efficient and specific side-chain oxidation of 3 beta-acetoxy-5 alpha-cholest-8(14)-en-15-one for construction of metabolites and analogs of the 15-ketosterol.
    Herz JE, Swaminathan S, Pinkerton FD, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1992 Apr 24; 33(4):579-98. PubMed ID: 1527481
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of sterol synthesis: effects of a 7 alpha-alkyl analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells and on serum cholesterol levels and other parameters in rats.
    Siddiqui AU, Gerst N, Kim LJ, Pinkerton FD, Kisic A, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1994 Apr 19; 70(2):163-78. PubMed ID: 8033288
    [Abstract] [Full Text] [Related]

  • 10. Inhibitors of sterol synthesis. Synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholestan-15-one and its 17 beta-epimer and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity.
    Siddiqui AU, Wilson WK, Parish EJ, Gerst N, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1994 Oct 20; 74(1):1-15. PubMed ID: 7820900
    [Abstract] [Full Text] [Related]

  • 11. Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.
    Wilson WK, Pinkerton FD, Kirkpatrick ND, Schroepfer GJ.
    J Lipid Res; 1989 Jun 20; 30(6):919-28. PubMed ID: 2794782
    [Abstract] [Full Text] [Related]

  • 12. Inhibitors of sterol synthesis. Metabolism-based design and construction of a new analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects in cultured mammalian cells and in rats.
    Swaminathan S, Siddiqui AU, Gerst N, Pinkerton FD, Kisic A, Kim LJ, Wilson WK, Schroepfer GJ.
    J Lipid Res; 1995 Apr 20; 36(4):767-86. PubMed ID: 7616123
    [Abstract] [Full Text] [Related]

  • 13. Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.
    Schroepfer GJ, Parish EJ, Tsuda M, Kandutsch AA.
    Chem Phys Lipids; 1988 Jul 20; 47(3):187-207. PubMed ID: 3168085
    [Abstract] [Full Text] [Related]

  • 14. Enzymatic formation and chemical synthesis of an active metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one, a potent regulator of cholesterol metabolism.
    Schroepfer GJ, Kim HS, Vermilion JL, Stephens TW, Pinkerton FD, Needleman DH, Wilson WK, St Pyrek J.
    Biochem Biophys Res Commun; 1988 Feb 29; 151(1):130-6. PubMed ID: 3348769
    [Abstract] [Full Text] [Related]

  • 15. Sterol synthesis. Synthesis of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluorocholest-5-en-7-one and its effects on HMG-CoA reductase activity in Chinese hamster ovary cells, on ACAT activity in rat jejunal microsomes, and serum cholesterol levels in rats.
    Carroll JN, Pinkerton FD, Su X, Gerst N, Wilson WK, Schroepfer GJ.
    Chem Phys Lipids; 1998 Aug 29; 94(2):209-25. PubMed ID: 9779586
    [Abstract] [Full Text] [Related]

  • 16. Inhibitors of sterol synthesis. Synthesis and spectral properties of 3 beta-hydroxy-24-dimethylamino-5 alpha-chol-8(14)-en-15-one and its effects on HMG-CoA reductase activity in CHO-K1 cells.
    Herz JE, Wilson WK, Pinkerton FD, Schroepfer GJ.
    Chem Phys Lipids; 1991 Nov 29; 60(1):61-9. PubMed ID: 1813179
    [Abstract] [Full Text] [Related]

  • 17. Inhibitors of sterol synthesis. 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, an active metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.
    Swaminathan S, Pinkerton FD, Schroepfer GJ.
    J Med Chem; 1992 Feb 21; 35(4):793-5. PubMed ID: 1542104
    [No Abstract] [Full Text] [Related]

  • 18. Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.
    Kim HS, Wilson WK, Needleman DH, Pinkerton FD, Wilson DK, Quiocho FA, Schroepfer GJ.
    J Lipid Res; 1989 Feb 21; 30(2):247-61. PubMed ID: 2715729
    [Abstract] [Full Text] [Related]

  • 19. Chemical synthesis of 15-ketosterols and their inhibitions of cholesteryl ester transfer protein.
    Kim HS, Oh SH, Kim DI, Kim IC, Cho KH, Park YB.
    Bioorg Med Chem; 1995 Apr 21; 3(4):367-74. PubMed ID: 8581419
    [Abstract] [Full Text] [Related]

  • 20. Inhibitors of sterol synthesis. Characterization of trimethylsilyl dienol ethers of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one. Applications in the analysis of mitochondrial metabolites of the 15-ketosterol by gas chromatography-mass spectrometry.
    St Pyrek J, Wilson WK, Numazawa S, Schoepfer GJ.
    J Lipid Res; 1991 Aug 21; 32(8):1371-80. PubMed ID: 1770319
    [Abstract] [Full Text] [Related]


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