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52 related items for PubMed ID: 19413589

  • 1. Reduction of Abeta42 in brains of transgenic APPswe mice by 2-3-chlorophenylaminophenylacetate.
    Cohen MP, Shearman CW.
    Clin Exp Pharmacol Physiol; 2009 Nov; 36(11):1099-103. PubMed ID: 19413589
    [Abstract] [Full Text] [Related]

  • 2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
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  • 3. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 24; 100(3):802-9. PubMed ID: 17156133
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  • 4. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.
    J Pharmacol Exp Ther; 2007 Dec 24; 323(3):822-30. PubMed ID: 17895400
    [Abstract] [Full Text] [Related]

  • 5. Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice.
    Liu L, Herukka SK, Minkeviciene R, van Groen T, Tanila H.
    Neurobiol Dis; 2004 Dec 24; 17(3):516-23. PubMed ID: 15571987
    [Abstract] [Full Text] [Related]

  • 6. Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
    Van Broeck B, Vanhoutte G, Pirici D, Van Dam D, Wils H, Cuijt I, Vennekens K, Zabielski M, Michalik A, Theuns J, De Deyn PP, Van der Linden A, Van Broeckhoven C, Kumar-Singh S.
    Neurobiol Aging; 2008 Feb 24; 29(2):241-52. PubMed ID: 17112635
    [Abstract] [Full Text] [Related]

  • 7. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 24; 96(5):1322-35. PubMed ID: 16478525
    [Abstract] [Full Text] [Related]

  • 8. Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
    Abramowski D, Wiederhold KH, Furrer U, Jaton AL, Neuenschwander A, Runser MJ, Danner S, Reichwald J, Ammaturo D, Staab D, Stoeckli M, Rueeger H, Neumann U, Staufenbiel M.
    J Pharmacol Exp Ther; 2008 Nov 24; 327(2):411-24. PubMed ID: 18687920
    [Abstract] [Full Text] [Related]

  • 9. In vitro and in vivo staining characteristics of small, fluorescent, Abeta42-binding D-enantiomeric peptides in transgenic AD mouse models.
    van Groen T, Kadish I, Wiesehan K, Funke SA, Willbold D.
    ChemMedChem; 2009 Feb 24; 4(2):276-82. PubMed ID: 19072935
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  • 14. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
    He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, Zhang Y, Xu H, Tempier A, Li X, Li XM.
    Neurobiol Aging; 2009 Aug 24; 30(8):1205-16. PubMed ID: 18079026
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  • 15. Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.
    Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H.
    Neurosci Lett; 2008 Jun 20; 438(2):216-20. PubMed ID: 18455870
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  • 16. Active immunization trial in Abeta42-injected P301L tau transgenic mice.
    Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri MH, Li H, Nitsch RM, Götz J.
    Neurobiol Dis; 2006 Apr 20; 22(1):50-6. PubMed ID: 16289870
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  • 17. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.
    Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J.
    Neuroscience; 2006 Nov 03; 142(4):941-52. PubMed ID: 16938404
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  • 18. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar 03; 324(3):957-69. PubMed ID: 18156464
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  • 19. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
    Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M.
    Nat Neurosci; 2004 Sep 03; 7(9):954-60. PubMed ID: 15311281
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