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Journal Abstract Search

317 related items for PubMed ID: 19442247

  • 1. Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease.
    Lindahl T, Barnes DE, Yang YG, Robins P.
    Biochem Soc Trans; 2009 Jun; 37(Pt 3):535-8. PubMed ID: 19442247
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  • 2. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.
    Yang YG, Lindahl T, Barnes DE.
    Cell; 2007 Nov 30; 131(5):873-86. PubMed ID: 18045533
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  • 3. C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy.
    Richards A, van den Maagdenberg AM, Jen JC, Kavanagh D, Bertram P, Spitzer D, Liszewski MK, Barilla-Labarca ML, Terwindt GM, Kasai Y, McLellan M, Grand MG, Vanmolkot KR, de Vries B, Wan J, Kane MJ, Mamsa H, Schäfer R, Stam AH, Haan J, de Jong PT, Storimans CW, van Schooneveld MJ, Oosterhuis JA, Gschwendter A, Dichgans M, Kotschet KE, Hodgkinson S, Hardy TA, Delatycki MB, Hajj-Ali RA, Kothari PH, Nelson SF, Frants RR, Baloh RW, Ferrari MD, Atkinson JP.
    Nat Genet; 2007 Sep 30; 39(9):1068-70. PubMed ID: 17660820
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  • 4. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
    Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N.
    Nat Genet; 2007 Sep 30; 39(9):1065-7. PubMed ID: 17660818
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  • 5. The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.
    Orebaugh CD, Fye JM, Harvey S, Hollis T, Perrino FW.
    J Biol Chem; 2011 Nov 18; 286(46):40246-54. PubMed ID: 21937424
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  • 6. Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.
    Fye JM, Orebaugh CD, Coffin SR, Hollis T, Perrino FW.
    J Biol Chem; 2011 Sep 16; 286(37):32373-82. PubMed ID: 21808053
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  • 7. Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.
    Grieves JL, Fye JM, Harvey S, Grayson JM, Hollis T, Perrino FW.
    Proc Natl Acad Sci U S A; 2015 Apr 21; 112(16):5117-22. PubMed ID: 25848017
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  • 8. The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease.
    Lehtinen DA, Harvey S, Mulcahy MJ, Hollis T, Perrino FW.
    J Biol Chem; 2008 Nov 14; 283(46):31649-56. PubMed ID: 18805785
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  • 9. The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.
    Fye JM, Coffin SR, Orebaugh CD, Hollis T, Perrino FW.
    J Biol Chem; 2014 Apr 18; 289(16):11556-11565. PubMed ID: 24616097
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  • 12. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
    Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC.
    J Autoimmun; 2017 Jul 18; 81():13-23. PubMed ID: 28325644
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  • 14. Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.
    Yuan F, Dutta T, Wang L, Song L, Gu L, Qian L, Benitez A, Ning S, Malhotra A, Deutscher MP, Zhang Y.
    J Biol Chem; 2015 May 22; 290(21):13344-53. PubMed ID: 25855793
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  • 19. Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.
    Gray EE, Treuting PM, Woodward JJ, Stetson DB.
    J Immunol; 2015 Sep 01; 195(5):1939-43. PubMed ID: 26223655
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