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Journal Abstract Search

222 related items for PubMed ID: 19443216

  • 1. Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
    Ritzén A, Sindet R, Hentzer M, Svendsen N, Brodbeck RM, Bundgaard C.
    Bioorg Med Chem Lett; 2009 Jun 15; 19(12):3275-8. PubMed ID: 19443216
    [Abstract] [Full Text] [Related]

  • 2. Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
    Zhao Z, Wisnoski DD, O'Brien JA, Lemaire W, Williams DL, Jacobson MA, Wittman M, Ha SN, Schaffhauser H, Sur C, Pettibone DJ, Duggan ME, Conn PJ, Hartman GD, Lindsley CW.
    Bioorg Med Chem Lett; 2007 Mar 01; 17(5):1386-91. PubMed ID: 17210250
    [Abstract] [Full Text] [Related]

  • 3. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR.
    J Med Chem; 2004 Nov 18; 47(24):5825-8. PubMed ID: 15537338
    [Abstract] [Full Text] [Related]

  • 4. N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.
    Packiarajan M, Mazza Ferreira CG, Hong SP, White AD, Chandrasena G, Pu X, Brodbeck RM, Robichaud AJ.
    Bioorg Med Chem Lett; 2012 Sep 01; 22(17):5658-62. PubMed ID: 22832311
    [Abstract] [Full Text] [Related]

  • 5. The identification of novel orally active mGluR5 antagonist GSK2210875.
    Pilla M, Andreoli M, Tessari M, Delle-Fratte S, Roth A, Butler S, Brown F, Shah P, Bettini E, Cavallini P, Benedetti R, Minick D, Smith P, Tehan B, D'Alessandro P, Lorthioir O, Ball C, Garzya V, Goodacre C, Watson S.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7521-4. PubMed ID: 21051228
    [Abstract] [Full Text] [Related]

  • 6. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.
    Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Schaffhauser H, Rowe BA, Daggett LP, Vernier JM.
    Bioorg Med Chem Lett; 2004 Dec 06; 14(23):5867-72. PubMed ID: 15501058
    [Abstract] [Full Text] [Related]

  • 7. 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
    Brnardic EJ, Fraley ME, Garbaccio RM, Layton ME, Sanders JM, Culberson C, Jacobson MA, Magliaro BC, Hutson PH, O'Brien JA, Huszar SL, Uslaner JM, Fillgrove KL, Tang C, Kuo Y, Sur SM, Hartman GD.
    Bioorg Med Chem Lett; 2010 May 15; 20(10):3129-33. PubMed ID: 20409708
    [Abstract] [Full Text] [Related]

  • 8. Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
    Bonnefous C, Vernier JM, Hutchinson JH, Gardner MF, Cramer M, James JK, Rowe BA, Daggett LP, Schaffhauser H, Kamenecka TM.
    Bioorg Med Chem Lett; 2005 Oct 01; 15(19):4354-8. PubMed ID: 16046122
    [Abstract] [Full Text] [Related]

  • 9. 4-aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators.
    Xiong H, Brugel TA, Balestra M, Brown DG, Brush KA, Hightower C, Hinkley L, Hoesch V, Kang J, Koether GM, McCauley JP, McLaren FM, Panko LM, Simpson TR, Smith RW, Woods JM, Brockel B, Chhajlani V, Gadient RA, Spear N, Sygowski LA, Zhang M, Arora J, Breysse N, Wilson JM, Isaac M, Slassi A, King MM.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7381-4. PubMed ID: 21067920
    [Abstract] [Full Text] [Related]

  • 10. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
    Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Rowe BA, Schaffhauser H, Rodriguez DE, Campbell UC, Daggett LP, Vernier JM.
    Bioorg Med Chem Lett; 2005 Mar 15; 15(6):1565-71. PubMed ID: 15745798
    [Abstract] [Full Text] [Related]

  • 11. 3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
    Zhang L, Rogers BN, Duplantier AJ, McHardy SF, Efremov I, Berke H, Qian W, Zhang AQ, Maklad N, Candler J, Doran AC, Lazzaro JT, Ganong AH.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5493-6. PubMed ID: 18812259
    [Abstract] [Full Text] [Related]

  • 12. Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).
    Bach P, Nilsson K, Svensson T, Bauer U, Hammerland LG, Peterson A, Wållberg A, Osterlund K, Karis D, Boije M, Wensbo D.
    Bioorg Med Chem Lett; 2006 Sep 15; 16(18):4788-91. PubMed ID: 16837196
    [Abstract] [Full Text] [Related]

  • 13. Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
    Nakamura M, Kurihara H, Suzuki G, Mitsuya M, Ohkubo M, Ohta H.
    Bioorg Med Chem Lett; 2010 Jan 15; 20(2):726-9. PubMed ID: 20005101
    [Abstract] [Full Text] [Related]

  • 14. Structure-activity relationships for negative allosteric mGluR5 modulators.
    Kaae BH, Harpsøe K, Kvist T, Mathiesen JM, Mølck C, Gloriam D, Jimenez HN, Uberti MA, Nielsen SM, Nielsen B, Bräuner-Osborne H, Sauerberg P, Clausen RP, Madsen U.
    ChemMedChem; 2012 Mar 05; 7(3):440-51. PubMed ID: 22267204
    [Abstract] [Full Text] [Related]

  • 15. Recent progress in the development of allosteric modulators of mGluR5.
    Rodriguez AL, Williams R.
    Curr Opin Drug Discov Devel; 2007 Nov 05; 10(6):715-22. PubMed ID: 17987523
    [Abstract] [Full Text] [Related]

  • 16. Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
    Pinkerton AB, Vernier JM, Schaffhauser H, Rowe BA, Campbell UC, Rodriguez DE, Lorrain DS, Baccei CS, Daggett LP, Bristow LJ.
    J Med Chem; 2004 Aug 26; 47(18):4595-9. PubMed ID: 15317469
    [Abstract] [Full Text] [Related]

  • 17. SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide.
    Barda DA, Wang ZQ, Britton TC, Henry SS, Jagdmann GE, Coleman DS, Johnson MP, Andis SL, Schoepp DD.
    Bioorg Med Chem Lett; 2004 Jun 21; 14(12):3099-102. PubMed ID: 15149652
    [Abstract] [Full Text] [Related]

  • 18. Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
    Kubas H, Meyer U, Krueger B, Hechenberger M, Vanejevs M, Zemribo R, Kauss V, Ambartsumova R, Pyatkin I, Polosukhin AI, Abel U.
    Bioorg Med Chem Lett; 2013 Aug 15; 23(16):4493-500. PubMed ID: 23856046
    [Abstract] [Full Text] [Related]

  • 19. Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
    Sams AG, Mikkelsen GK, Brodbeck RM, Pu X, Ritzén A.
    Bioorg Med Chem Lett; 2011 Jun 01; 21(11):3407-10. PubMed ID: 21531137
    [Abstract] [Full Text] [Related]

  • 20. 3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
    Duplantier AJ, Efremov I, Candler J, Doran AC, Ganong AH, Haas JA, Hanks AN, Kraus KG, Lazzaro JT, Lu J, Maklad N, McCarthy SA, O'Sullivan TJ, Rogers BN, Siuciak JA, Spracklin DK, Zhang L.
    Bioorg Med Chem Lett; 2009 May 01; 19(9):2524-9. PubMed ID: 19328692
    [Abstract] [Full Text] [Related]

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