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Journal Abstract Search

386 related items for PubMed ID: 19453301

  • 1. Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
    Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CC, Shaw PJ, Grierson AJ.
    J Neurochem; 2009 Jul; 110(1):34-44. PubMed ID: 19453301
    [Abstract] [Full Text] [Related]

  • 2. Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.
    Denton KR, Lei L, Grenier J, Rodionov V, Blackstone C, Li XJ.
    Stem Cells; 2014 Feb; 32(2):414-23. PubMed ID: 24123785
    [Abstract] [Full Text] [Related]

  • 3. Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.
    Fassier C, Tarrade A, Peris L, Courageot S, Mailly P, Dalard C, Delga S, Roblot N, Lefèvre J, Job D, Hazan J, Curmi PA, Melki J.
    Dis Model Mech; 2013 Jan; 6(1):72-83. PubMed ID: 22773755
    [Abstract] [Full Text] [Related]

  • 4. Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation.
    Leo L, Weissmann C, Burns M, Kang M, Song Y, Qiang L, Brady ST, Baas PW, Morfini G.
    Hum Mol Genet; 2017 Jun 15; 26(12):2321-2334. PubMed ID: 28398512
    [Abstract] [Full Text] [Related]

  • 5. Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse.
    Qiang L, Piermarini E, Muralidharan H, Yu W, Leo L, Hennessy LE, Fernandes S, Connors T, Yates PL, Swift M, Zholudeva LV, Lane MA, Morfini G, Alexander GM, Heiman-Patterson TD, Baas PW.
    Hum Mol Genet; 2019 Apr 01; 28(7):1136-1152. PubMed ID: 30520996
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  • 7. Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.
    McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KM, Shaw PJ.
    Ann Neurol; 2003 Dec 01; 54(6):748-59. PubMed ID: 14681884
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  • 10. Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.
    Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B.
    Hum Mol Genet; 2014 May 15; 23(10):2527-41. PubMed ID: 24381312
    [Abstract] [Full Text] [Related]

  • 11. Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing.
    Evans KJ, Gomes ER, Reisenweber SM, Gundersen GG, Lauring BP.
    J Cell Biol; 2005 Feb 14; 168(4):599-606. PubMed ID: 15716377
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  • 12. The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.
    Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ, Cunliffe VT.
    Hum Mol Genet; 2006 Sep 15; 15(18):2763-71. PubMed ID: 16893913
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  • 13. A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations.
    Abrahamsen G, Fan Y, Matigian N, Wali G, Bellette B, Sutharsan R, Raju J, Wood SA, Veivers D, Sue CM, Mackay-Sim A.
    Dis Model Mech; 2013 Mar 15; 6(2):489-502. PubMed ID: 23264559
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  • 14. The cellular and molecular pathology of the motor system in hereditary spastic paraparesis due to mutation of the spastin gene.
    Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG, Shaw PJ.
    J Neuropathol Exp Neurol; 2003 Nov 15; 62(11):1166-77. PubMed ID: 14656074
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  • 15. Modeling gain-of-function and loss-of-function components of SPAST-based hereditary spastic paraplegia using transgenic mice.
    Piermarini E, Akarsu S, Connors T, Kneussel M, Lane MA, Morfini G, Karabay A, Baas PW, Qiang L.
    Hum Mol Genet; 2022 Jun 04; 31(11):1844-1859. PubMed ID: 34935948
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  • 16. Axonal transport deficit in a KIF5A( -/- ) mouse model.
    Karle KN, Möckel D, Reid E, Schöls L.
    Neurogenetics; 2012 May 04; 13(2):169-79. PubMed ID: 22466687
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  • 17. Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP).
    Baxter SL, Allard DE, Crowl C, Sherwood NT.
    Dis Model Mech; 2014 Aug 04; 7(8):1005-12. PubMed ID: 24906373
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  • 18. Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin.
    Connell JW, Allison R, Reid E.
    PLoS One; 2016 Aug 04; 11(3):e0152413. PubMed ID: 27019090
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  • 19. Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.
    Butler R, Wood JD, Landers JA, Cunliffe VT.
    Dis Model Mech; 2010 Aug 04; 3(11-12):743-51. PubMed ID: 20829563
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  • 20. Role of spastin and protrudin in neurite outgrowth.
    Zhang C, Li D, Ma Y, Yan J, Yang B, Li P, Yu A, Lu C, Ma X.
    J Cell Biochem; 2012 Jul 04; 113(7):2296-307. PubMed ID: 22573551
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