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Journal Abstract Search

350 related items for PubMed ID: 19454261

  • 1. Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.
    Volbracht C, Penzkofer S, Mansson D, Christensen KV, Fog K, Schildknecht S, Leist M, Nielsen J.
    Anal Biochem; 2009 Apr 15; 387(2):208-20. PubMed ID: 19454261
    [Abstract] [Full Text] [Related]

  • 2. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.
    J Neurochem; 2006 Dec 15; 99(6):1555-63. PubMed ID: 17083447
    [Abstract] [Full Text] [Related]

  • 3. Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
    Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC.
    J Neurochem; 2004 Dec 15; 91(6):1249-59. PubMed ID: 15584902
    [Abstract] [Full Text] [Related]

  • 4. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar 15; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 5. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
    Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.
    J Pharmacol Exp Ther; 2008 Aug 15; 326(2):502-13. PubMed ID: 18499745
    [Abstract] [Full Text] [Related]

  • 6. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 15; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 7. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.
    J Neurosci Res; 2007 Jan 15; 85(1):153-65. PubMed ID: 17075903
    [Abstract] [Full Text] [Related]

  • 8. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
    Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ.
    Proc Natl Acad Sci U S A; 2006 Nov 21; 103(47):17967-72. PubMed ID: 17098871
    [Abstract] [Full Text] [Related]

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  • 10. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH, Jeon SH, Zhang G, Olson GL, Chae CB.
    J Neurochem; 2007 Jun 21; 101(6):1583-95. PubMed ID: 17542811
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  • 12. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.
    J Neurosci Res; 2011 Jun 21; 89(6):822-32. PubMed ID: 21433051
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  • 14. Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent.
    Hartlage-Rübsamen M, Zeitschel U, Apelt J, Gärtner U, Franke H, Stahl T, Günther A, Schliebs R, Penkowa M, Bigl V, Rossner S.
    Glia; 2003 Jan 15; 41(2):169-79. PubMed ID: 12509807
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  • 15. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
    Parvathy S, Hussain I, Karran EH, Turner AJ, Hooper NM.
    Biochemistry; 1999 Jul 27; 38(30):9728-34. PubMed ID: 10423252
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  • 17. Identification of beta-secretase-like activity using a mass spectrometry-based assay system.
    Grüninger-Leitch F, Berndt P, Langen H, Nelboeck P, Döbeli H.
    Nat Biotechnol; 2000 Jan 27; 18(1):66-70. PubMed ID: 10625394
    [Abstract] [Full Text] [Related]

  • 18. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
    Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W.
    FASEB J; 2005 May 27; 19(7):739-49. PubMed ID: 15857888
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  • 20. The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.
    von Einem B, Schwanzar D, Rehn F, Beyer AS, Weber P, Wagner M, Schneckenburger H, von Arnim CA.
    Exp Neurol; 2010 Sep 27; 225(1):85-93. PubMed ID: 20685197
    [Abstract] [Full Text] [Related]

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