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426 related items for PubMed ID: 19457072

  • 1. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.
    Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D.
    J Neurochem; 2009 Jul; 110(1):244-54. PubMed ID: 19457072
    [Abstract] [Full Text] [Related]

  • 2. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 3. Native gamma-aminobutyric acid type A receptors from rat hippocampus, containing both alpha 1 and alpha 5 subunits, exhibit a single benzodiazepine binding site with alpha 5 pharmacological properties.
    Araujo F, Ruano D, Vitorica J.
    J Pharmacol Exp Ther; 1999 Sep; 290(3):989-97. PubMed ID: 10454469
    [Abstract] [Full Text] [Related]

  • 4. Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
    Whittemore ER, Yang W, Drewe JA, Woodward RM.
    Mol Pharmacol; 1996 Nov; 50(5):1364-75. PubMed ID: 8913369
    [Abstract] [Full Text] [Related]

  • 5. Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
    Kelly MD, Smith A, Banks G, Wingrove P, Whiting PW, Atack J, Seabrook GR, Maubach KA.
    Br J Pharmacol; 2002 Jan; 135(1):248-56. PubMed ID: 11786501
    [Abstract] [Full Text] [Related]

  • 6. In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.
    Atack JR, Alder L, Cook SM, Smith AJ, McKernan RM.
    Neuropharmacology; 2005 Aug; 49(2):220-9. PubMed ID: 15996568
    [Abstract] [Full Text] [Related]

  • 7. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.
    Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR.
    J Psychopharmacol; 2007 Jun; 21(4):384-91. PubMed ID: 17092983
    [Abstract] [Full Text] [Related]

  • 8. Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.
    Huh KH, Delorey TM, Endo S, Olsen RW.
    Mol Pharmacol; 1995 Oct; 48(4):666-75. PubMed ID: 7476892
    [Abstract] [Full Text] [Related]

  • 9. Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site.
    Buhr A, Baur R, Malherbe P, Sigel E.
    Mol Pharmacol; 1996 Jun; 49(6):1080-4. PubMed ID: 8649346
    [Abstract] [Full Text] [Related]

  • 10. Impact of subunit positioning on GABAA receptor function.
    Sigel E, Baur R, Boulineau N, Minier F.
    Biochem Soc Trans; 2006 Nov; 34(Pt 5):868-71. PubMed ID: 17052217
    [Abstract] [Full Text] [Related]

  • 11. The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.
    McKernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, Whiting PJ.
    J Recept Signal Transduct Res; 1995 Nov; 15(1-4):173-83. PubMed ID: 8903939
    [Abstract] [Full Text] [Related]

  • 12. Functional mapping of GABA A receptor subtypes in the amygdala.
    Marowsky A, Fritschy JM, Vogt KE.
    Eur J Neurosci; 2004 Sep; 20(5):1281-9. PubMed ID: 15341600
    [Abstract] [Full Text] [Related]

  • 13. Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
    Dean B, Scarr E, McLeod M.
    Brain Res Mol Brain Res; 2005 Aug 18; 138(2):145-55. PubMed ID: 15950312
    [Abstract] [Full Text] [Related]

  • 14. Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
    Korpi ER, Kleingoor C, Kettenmann H, Seeburg PH.
    Nature; 1993 Jan 28; 361(6410):356-9. PubMed ID: 7678923
    [Abstract] [Full Text] [Related]

  • 15. The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors.
    Hales TG, Tang H, Bollan KA, Johnson SJ, King DP, McDonald NA, Cheng A, Connolly CN.
    Mol Cell Neurosci; 2005 May 28; 29(1):120-7. PubMed ID: 15866052
    [Abstract] [Full Text] [Related]

  • 16. Palmitoylation regulates the clustering and cell surface stability of GABAA receptors.
    Rathenberg J, Kittler JT, Moss SJ.
    Mol Cell Neurosci; 2004 Jun 28; 26(2):251-7. PubMed ID: 15207850
    [Abstract] [Full Text] [Related]

  • 17. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.
    Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H.
    Nature; 1999 Oct 21; 401(6755):796-800. PubMed ID: 10548105
    [Abstract] [Full Text] [Related]

  • 18. Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
    Tan KR, Baur R, Gonthier A, Goeldner M, Sigel E.
    FEBS Lett; 2007 Oct 02; 581(24):4718-22. PubMed ID: 17854801
    [Abstract] [Full Text] [Related]

  • 19. GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes.
    Mikkelsen JD, Bundzikova J, Larsen MH, Hansen HH, Kiss A.
    Ann N Y Acad Sci; 2008 Dec 02; 1148():384-92. PubMed ID: 19120132
    [Abstract] [Full Text] [Related]

  • 20. Assembly of GABA(A) receptors (Review).
    Sarto-Jackson I, Sieghart W.
    Mol Membr Biol; 2008 May 02; 25(4):302-10. PubMed ID: 18446616
    [Abstract] [Full Text] [Related]

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