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1510 related items for PubMed ID: 19457123

  • 1. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
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  • 2. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
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  • 3. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
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  • 4. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
    Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C.
    J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
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  • 5. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
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  • 6. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.
    Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.
    J Neurochem; 2006 Jan 05; 96(1):118-25. PubMed ID: 16300640
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  • 7. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 05; 57(3):446-53. PubMed ID: 17210196
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  • 8. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 05; 25(2):291-6. PubMed ID: 17071095
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  • 9. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
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  • 12. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
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  • 15. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
    Steiner H, Winkler E, Shearman MS, Prywes R, Haass C.
    Neurobiol Dis; 2001 Aug 01; 8(4):717-22. PubMed ID: 11493036
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  • 16. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 01; 20(2):625-37. PubMed ID: 15936948
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  • 18. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
    Edbauer D, Winkler E, Haass C, Steiner H.
    Proc Natl Acad Sci U S A; 2002 Jun 25; 99(13):8666-71. PubMed ID: 12048259
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  • 19. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H, Winblad B, Näslund J.
    Physiol Behav; 2007 Sep 10; 92(1-2):115-20. PubMed ID: 17588625
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  • 20. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 10; 100(3):802-9. PubMed ID: 17156133
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