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198 related items for PubMed ID: 19468689

  • 1. MER1, a novel organic arsenic derivative, has potent PML-RARalpha-independent cytotoxic activity against leukemia cells.
    Golemovic M, Quintás-Cardama A, Manshouri T, Orsolic N, Duzkale H, Johansen M, Freireich EJ, Kantarjian H, Zingaro RA, Verstovsek S.
    Invest New Drugs; 2010 Aug; 28(4):402-12. PubMed ID: 19468689
    [Abstract] [Full Text] [Related]

  • 2. The organic arsenic derivative GMZ27 induces PML-RARα-independent apoptosis in myeloid leukemia cells.
    Cheng X, Quintás-Cardama A, Golemovic M, Zingaro R, Gao MZ, Freireich EJ, Andreeff M, Kantarjian HM, Verstovsek S.
    Anticancer Res; 2012 Jul; 32(7):2871-80. PubMed ID: 22753750
    [Abstract] [Full Text] [Related]

  • 3. Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1.
    Wang R, Liu C, Xia L, Zhao G, Gabrilove J, Waxman S, Jing Y.
    Clin Cancer Res; 2012 Dec 15; 18(24):6690-701. PubMed ID: 23082001
    [Abstract] [Full Text] [Related]

  • 4. PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase.
    Li L, Wang J, Ye RD, Shi G, Jin H, Tang X, Yi J.
    J Cell Physiol; 2008 Nov 15; 217(2):486-93. PubMed ID: 18636556
    [Abstract] [Full Text] [Related]

  • 5. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.
    Wang ZG, Rivi R, Delva L, König A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove JL, Warrell RP, Pandolfi PP.
    Blood; 1998 Sep 01; 92(5):1497-504. PubMed ID: 9716575
    [Abstract] [Full Text] [Related]

  • 6. Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells.
    Nayak S, Shen M, Bunaciu RP, Bloom SE, Varner JD, Yen A.
    Leuk Lymphoma; 2010 Sep 01; 51(9):1734-47. PubMed ID: 20615082
    [Abstract] [Full Text] [Related]

  • 7. The optimal dose of arsenic trioxide induced opposite efficacy in autophagy between K562 cells and their initiating cells to eradicate human myelogenous leukemia.
    Guo Z, Meng M, Geng S, Du Z, Zheng Y, Yao J, Li Z, Han G, Lin H, Du G.
    J Ethnopharmacol; 2017 Jan 20; 196():29-38. PubMed ID: 27965050
    [Abstract] [Full Text] [Related]

  • 8. PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
    Sternsdorf T, Puccetti E, Jensen K, Hoelzer D, Will H, Ottmann OG, Ruthardt M.
    Mol Cell Biol; 1999 Jul 20; 19(7):5170-8. PubMed ID: 10373566
    [Abstract] [Full Text] [Related]

  • 9. Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide.
    Liu L, Chen C, Gong W, Li Y, Edin ML, Zeldin DC, Wang DW.
    J Pharmacol Exp Ther; 2011 Nov 20; 339(2):451-63. PubMed ID: 21846841
    [Abstract] [Full Text] [Related]

  • 10. In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies.
    Giannì M, de Thé H.
    Leukemia; 1999 May 20; 13(5):739-49. PubMed ID: 10374879
    [Abstract] [Full Text] [Related]

  • 11. Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL.
    Liu Q, Hilsenbeck S, Gazitt Y.
    Blood; 2003 May 15; 101(10):4078-87. PubMed ID: 12531793
    [Abstract] [Full Text] [Related]

  • 12. Increased cellular glutathione and protection by bone marrow stromal cells account for the resistance of non-acute promylocytic leukemia acute myeloid leukemia cells to arsenic trioxide in vivo.
    Lee C, Lin Y, Huang M, Lin C, Liu C, Chow J, Liu HE.
    Leuk Lymphoma; 2006 Mar 15; 47(3):521-9. PubMed ID: 16396776
    [Abstract] [Full Text] [Related]

  • 13. Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
    Sánchez Y, Simón GP, Calviño E, de Blas E, Aller P.
    J Pharmacol Exp Ther; 2010 Oct 15; 335(1):114-23. PubMed ID: 20605902
    [Abstract] [Full Text] [Related]

  • 14. Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation.
    Wang QQ, Zhou XY, Zhang YF, Bu N, Zhou J, Cao FL, Naranmandura H.
    Oncotarget; 2015 Sep 22; 6(28):25646-59. PubMed ID: 26213848
    [Abstract] [Full Text] [Related]

  • 15. Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.
    Zheng X, Seshire A, Rüster B, Bug G, Beissert T, Puccetti E, Hoelzer D, Henschler R, Ruthardt M.
    Haematologica; 2007 Mar 22; 92(3):323-31. PubMed ID: 17339181
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism.
    Bowling BD, Doudican N, Manga P, Orlow SJ.
    Cancer Chemother Pharmacol; 2008 Dec 22; 63(1):37-43. PubMed ID: 18297286
    [Abstract] [Full Text] [Related]

  • 17. RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner.
    Xu L, Zeng Z, Zhang W, Ren G, Ling X, Huang F, Xie P, Su Y, Zhang XK, Zhou H.
    Oncotarget; 2017 Feb 14; 8(7):12311-12322. PubMed ID: 28129653
    [Abstract] [Full Text] [Related]

  • 18. Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases.
    Huang XJ, Wiernik PH, Klein RS, Gallagher RE.
    Med Oncol; 1999 Apr 14; 16(1):58-64. PubMed ID: 10382944
    [Abstract] [Full Text] [Related]

  • 19. Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines.
    Ramos AM, Aller P.
    Biochem Pharmacol; 2008 May 15; 75(10):1912-23. PubMed ID: 18359480
    [Abstract] [Full Text] [Related]

  • 20. Additive antitumor effect of arsenic trioxide with exposure to ionizing radiation to human acute promyelocytic leukemia HL‑60 cells.
    Morino Y, Sugiyama H, Yamane K, Kikuchi M, Yamanaka T, Honda K, Monzen S.
    Oncol Rep; 2024 Aug 15; 52(2):. PubMed ID: 38963046
    [Abstract] [Full Text] [Related]

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